Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain.


:Recent years have seen major changes in our understanding of Parkinson disease (PD), challenging conventional wisdom, much of which was established during the Decade of the Brain. In this article, we highlight important changes in our understanding of PD in six general categories: definition, etiology, pathology, pathogenesis, clinical features, and therapeutics.






Marras C,Lang A




Has Abstract


2008-05-20 00:00:00














  • Ventilatory response in myotonic dystrophy.

    abstract::Patients with myotonic dystrophy often develop respiratory failure caused by alveolar hypoventilation. Abnormalities in the ventilatory response to hypoxia and hypercapnia may explain this phenomenon. Accordingly, hypoxic and hypercapnic responses were measured in seven patients with myotonic dystrophy who had only mi...


    pub_type: 杂志文章


    authors: Carroll JE,Zwillich CW,Weil JV

    更新日期:1977-12-01 00:00:00

  • Laryngeal botulinum toxin injections for disabling stuttering in adults.

    abstract::Stuttering is an action-induced speech disorder with involuntary, audible, or silent repetitions or prolongations in the utterance of short speech elements (sounds, syllables) and words. Symptomatic treatment programs frequently have initial success; persistent benefit is variable and many patients remain disabled. St...


    pub_type: 临床试验,杂志文章


    authors: Brin MF,Stewart C,Blitzer A,Diamond B

    更新日期:1994-12-01 00:00:00

  • Confusion and memory loss from capsular genu infarction: a thalamocortical disconnection syndrome?

    abstract::We examined six patients with an abrupt change in behavior after infarction involving the inferior genu of the internal capsule. The acute syndrome featured fluctuating alertness, inattention, memory loss, apathy, abulia, and psychomotor retardation, suggesting frontal lobe dysfunction. Contralateral hemiparesis and d...


    pub_type: 杂志文章


    authors: Tatemichi TK,Desmond DW,Prohovnik I,Cross DT,Gropen TI,Mohr JP,Stern Y

    更新日期:1992-10-01 00:00:00

  • Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis.

    abstract::Immunomodulating agents have beneficial effects in the treatment of multiple sclerosis (MS), decreasing the frequency of relapses, the progression of disability, and MRI measures of disease activity. Despite the efficacy of these agents, many patients continue to show progression of disability, breakthrough relapses, ...


    pub_type: 杂志文章,评审


    authors: Jeffery DR

    更新日期:2004-12-28 00:00:00

  • Evaluation of sleep and daytime somnolence in spinocerebellar ataxia type 6 (SCA6).

    abstract::To determine the frequency of subjective sleep problems in spinocerebellar ataxia type 6 (SCA6), the authors surveyed 25 patients and 25 age-matched controls with the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). The ESS was higher in patients with SCA6 (9.12 +/- 5.80; CI: 2.28) than in con...


    pub_type: 杂志文章


    authors: Howell MJ,Mahowald MW,Gomez CM

    更新日期:2006-05-09 00:00:00

  • Occurrence of sleep disorders in the families of narcoleptic patients.

    abstract::First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups....


    pub_type: 杂志文章


    authors: Ohayon MM,Okun ML

    更新日期:2006-08-22 00:00:00

  • Understanding co-morbidities affecting children with epilepsy.

    abstract::Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...


    pub_type: 杂志文章,评审


    authors: Pellock JM

    更新日期:2004-03-09 00:00:00

  • Auditory and tactile processing in a postmeningitic deaf-blind patient with a cochlear implant.

    abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...


    pub_type: 杂志文章


    authors: Osaki Y,Takasawa M,Doi K,Nishimura H,Iwaki T,Imaizumi M,Oku N,Hatazawa J,Kubo T

    更新日期:2006-09-12 00:00:00

  • Demonstration of CSF gamma-globulin banding in presenile dementia.

    abstract::An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients. ...


    pub_type: 杂志文章


    authors: Williams A,Papadopoulos N,Chase TN

    更新日期:1980-08-01 00:00:00

  • Factors influencing sweat gland innervation in diabetes.

    abstract:BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...


    pub_type: 杂志文章


    authors: Liu Y,Billiet J,Ebenezer GJ,Pan B,Hauer P,Wei J,Polydefkis M

    更新日期:2015-04-21 00:00:00

  • Regional and progressive thinning of the cortical ribbon in Huntington's disease.

    abstract:BACKGROUND:Huntington's disease (HD) is a fatal and progressive neurodegenerative disease that is accompanied by involuntary movements, cognitive dysfunction, and psychiatric symptoms. Although progressive striatal degeneration is known to occur, little is known about how the disease affects the cortex, including which...


    pub_type: 杂志文章


    authors: Rosas HD,Liu AK,Hersch S,Glessner M,Ferrante RJ,Salat DH,van der Kouwe A,Jenkins BG,Dale AM,Fischl B

    更新日期:2002-03-12 00:00:00

  • Burnout, career satisfaction, and well-being among US neurology residents and fellows in 2016.

    abstract:OBJECTIVE:To study prevalence of and factors contributing to burnout, career satisfaction, and well-being in US neurology residents and fellows. METHODS:A total of 938 US American Academy of Neurology member neurology residents and fellows were surveyed using standardized measures of burnout, career satisfaction, and ...


    pub_type: 杂志文章


    authors: Levin KH,Shanafelt TD,Keran CM,Busis NA,Foster LA,Molano JRV,O'Donovan CA,Ratliff JB,Schwarz HB,Sloan JA,Cascino TL

    更新日期:2017-08-01 00:00:00

  • Recurrence of ICH after resumption of anticoagulation with VK antagonists: CHIRONE study.

    abstract:OBJECTIVE:To evaluate the risk of recurrent intracranial hemorrhage (ICH) in patients on vitamin K antagonists (VKAs) after a first episode of ICH. METHODS:The Cerebral Haemorrhage in patients Restarting Oral Anticoagulant Therapy (CHIRONE) Study collected data of patients eligible for the study from the database of 2...


    pub_type: 杂志文章,多中心研究


    authors: Poli D,Antonucci E,Dentali F,Erba N,Testa S,Tiraferri E,Palareti G,Italian Federation of Anticoagulation Clinics (FCSA).

    更新日期:2014-03-25 00:00:00

  • Efficacy of mycophenolate mofetil in patients with chronic immune demyelinating polyneuropathy.

    abstract::The authors retrospectively reviewed the efficacy of mycophenolate mofetil (MMF; mean dose, 2 g/day given for an average of 14 months) in 21 patients with immune demyelinating polyneuropathy. There were no significant differences in the median strength, sensory, or Rankin scores before and after treatment. In patients...


    pub_type: 杂志文章,评审


    authors: Gorson KC,Amato AA,Ropper AH

    更新日期:2004-08-24 00:00:00

  • Specificity of the fivefold increase in AD in mothers of adults with Down syndrome.

    abstract:BACKGROUND:In a previous study, the authors found that the risk of AD among mothers who were 35 years or younger when their children with Down syndrome (DS) were born was five times that of mothers of children with other forms of mental retardation. The current study investigated the specificity of the familial aggrega...


    pub_type: 杂志文章


    authors: Schupf N,Kapell D,Nightingale B,Lee JH,Mohlenhoff J,Bewley S,Ottman R,Mayeux R

    更新日期:2001-09-25 00:00:00

  • The psychosocial consequences of pediatric multiple sclerosis.

    abstract::Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...


    pub_type: 杂志文章,评审


    authors: MacAllister WS,Boyd JR,Holland NJ,Milazzo MC,Krupp LB,International Pediatric MS Study Group.

    更新日期:2007-04-17 00:00:00

  • Effects of cannabis on cognitive function in patients with multiple sclerosis.

    abstract:BACKGROUND:While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in th...


    pub_type: 杂志文章


    authors: Honarmand K,Tierney MC,O'Connor P,Feinstein A

    更新日期:2011-03-29 00:00:00

  • Apolipoprotein E gene and sporadic frontal lobe dementia.

    abstract::The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...


    pub_type: 杂志文章


    authors: Stevens M,van Duijn CM,de Knijff P,van Broeckhoven C,Heutink P,Oostra BA,Niermeijer MF,van Swieten JC

    更新日期:1997-06-01 00:00:00

  • Central nervous system disease in patients with systemic lupus erythematosus.

    abstract::Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...


    pub_type: 杂志文章


    authors: Futrell N,Schultz LR,Millikan C

    更新日期:1992-09-01 00:00:00

  • Neuropathy and IgM M-proteins: prognostic value of antibodies to MAG, SGPG, and sulfatide.

    abstract:BACKGROUND:In polyneuropathy associated with immunoglobulin M (IgM) monoclonal gammopathy, antibodies to myelin-associated glycoprotein (MAG), sulfoglucuronyl paragloboside (SGPG), and sulfatide have been associated with specific clinical and electrophysiologic features. However, it is not known whether the results of ...


    pub_type: 杂志文章


    authors: Eurelings M,Moons KG,Notermans NC,Sasker LD,De Jager AE,Wintzen AR,Wokke JH,Van den Berg LH

    更新日期:2001-01-23 00:00:00

  • Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.

    abstract:BACKGROUND:Both AD and normal aging cause brain atrophy, limiting the ability of MRI to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging. OBJECTIVES:To determine the effects of AD on c...


    pub_type: 杂志文章,多中心研究


    authors: Schuff N,Capizzano AA,Du AT,Amend DL,O'Neill J,Norman D,Kramer J,Jagust W,Miller B,Wolkowitz OM,Yaffe K,Weiner MW

    更新日期:2002-03-26 00:00:00

  • Root stimulation studies in the evaluation of patients with motor neuron disease.

    abstract::Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...


    pub_type: 杂志文章


    authors: Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA

    更新日期:1998-06-01 00:00:00

  • Psychogenic seizures: ictal characteristics and diagnostic pitfalls.

    abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...


    pub_type: 杂志文章


    authors: Leis AA,Ross MA,Summers AK

    更新日期:1992-01-01 00:00:00

  • Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy.

    abstract:BACKGROUND:Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. METHODS:The auth...


    pub_type: 杂志文章


    authors: Gurol ME,Irizarry MC,Smith EE,Raju S,Diaz-Arrastia R,Bottiglieri T,Rosand J,Growdon JH,Greenberg SM

    更新日期:2006-01-10 00:00:00

  • Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study.

    abstract:OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...


    pub_type: 杂志文章,随机对照试验


    authors: Lipton RB,Tepper SJ,Reuter U,Silberstein S,Stewart WF,Nilsen J,Leonardi DK,Desai P,Cheng S,Mikol DD,Lenz R

    更新日期:2019-05-07 00:00:00

  • Medial medullary infarction with central sparing.

    abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...


    pub_type: 杂志文章


    authors: Ryman DC,Ju YE

    更新日期:2013-12-03 00:00:00

  • A competency-based longitudinal core curriculum in medical neuroscience.

    abstract::Current medical educational theory encourages the development of competency-based curricula. The Accreditation Council for Graduate Medical Education's 6 core competencies for resident education (medical knowledge, patient care, professionalism, interpersonal and communication skills, practice-based learning, and syst...


    pub_type: 杂志文章


    authors: Merlin LR,Horak HA,Milligan TA,Kraakevik JA,Ali II

    更新日期:2014-07-29 00:00:00

  • Small-fiber neuropathy in patients with ALS.

    abstract:OBJECTIVE:To investigate the involvement of the epidermal small sensory fibers in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). METHODS:In the present study, skin biopsies of 28 patients with ALS were obtained at an average of 34 months after disease onset by history. Protein gene product 9.5 (...


    pub_type: 杂志文章


    authors: Weis J,Katona I,Müller-Newen G,Sommer C,Necula G,Hendrich C,Ludolph AC,Sperfeld AD

    更新日期:2011-06-07 00:00:00

  • Age-specific norms for the Mini-Mental State Exam.

    abstract::We administered the Mini-Mental State Exam (MMSE) to 194 healthy men and women, ages 40 to 89 years. Total score was significantly associated with age (p less than 0.0001), but not vocabulary, education, Beck's Depression Inventory Score, or sex. The lowest quartile cutoff scores for the MMSE by decade were 40s - 29; ...


    pub_type: 杂志文章


    authors: Bleecker ML,Bolla-Wilson K,Kawas C,Agnew J

    更新日期:1988-10-01 00:00:00

  • Neurologic complications of influenza A(H1N1)pdm09: surveillance in 6 pediatric hospitals.

    abstract:OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...


    pub_type: 杂志文章,多中心研究


    authors: Khandaker G,Zurynski Y,Buttery J,Marshall H,Richmond PC,Dale RC,Royle J,Gold M,Snelling T,Whitehead B,Jones C,Heron L,McCaskill M,Macartney K,Elliott EJ,Booy R

    更新日期:2012-10-02 00:00:00