Abstract:
:In 10 patients with myasthenia gravis, we studied the relationship between plasma pyridostigmine levels and five measures of neuromuscular function (NMF) following single oral doses of 60 to 120 mg. The NMF measures were percent decrement of the evoked muscle compound potential, maximum force, force-time integral, vital capacity, and outstretched-arm time. The combined mean improvement was most significant 2 hours after pyridostigmine ingestion and coincided with the peak plasma pyridostigmine levels in eight patients. In seven patients, there was a positive correlation between plasma pyridostigmine levels and the mean percent improvement.
journal_name
Neurologyjournal_title
Neurologyauthors
Milner-Brown HS,Mellenthin M,Sharma ML,Miller RGdoi
10.1212/wnl.37.5.800subject
Has Abstractpub_date
1987-05-01 00:00:00pages
800-3issue
5eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
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