Abstract:
:Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Five others had variants of this pattern, and two had anterograde flow throughout the cardiac cycle, except at the end of diastole. This suggests that the internal carotid and proximal middle cerebral artery circulation remains patent, but distal resistance to flow in the brain is very high in the majority of brain-dead patients. Three other patients with absent brainstem reflexes but persistent EEG activity had normal TCD patterns. The characteristic pattern on TCD may be a useful ancillary finding in the diagnosis of brain death, and normal TCD patterns probably exclude the diagnosis.
journal_name
Neurologyjournal_title
Neurologyauthors
Ropper AH,Kehne SM,Wechsler Ldoi
10.1212/wnl.37.11.1733subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1733-5issue
11eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.5.1404
更新日期:1996-05-01 00:00:00
abstract::Menstrual disorders and infertility are common among women with epilepsy of temporal lobe origin (TLE). Reproductive endocrine disorders may be the cause. Polycystic ovarian syndrome (PCO) and hypothalamic amenorrhea (hypogonadotropic hypogonadism, HH), in particular, are significantly overrepresented and attributable...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.2.306
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182345896
更新日期:2011-10-25 00:00:00
abstract::Many advances in prevention, diagnosis, and treatment of neurologic disease have emerged in the last few decades, resulting in reduced mortality and decreased disability. However, these advances have not benefitted all populations equally. A growing body of evidence indicates that barriers to care fall along racial an...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000006874
更新日期:2019-02-05 00:00:00
abstract:OBJECTIVE:To determine the potential of detection in CSF of specific Borrelia burgdorferi antigen, OspA, as a marker of infection in neurologic Lyme disease and compare this with the detection of antibody. DESIGN:CSF from 83 neurologic patients in an area highly endemic for Lyme disease was examined prospectively for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.11.2010
更新日期:1995-11-01 00:00:00
abstract::We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.7.1034
更新日期:1991-07-01 00:00:00
abstract::Described are the clinical, EEG, MR, and genetic characteristics of 106 members of a family with autosomal dominant temporal lobe epilepsy (TLE) and febrile seizures (FS), with 22 affected individuals. Eleven patients had a history of FS, and 10 patients had TLE. EEG showed epileptic activity in five. None had hippoca...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.9.1429
更新日期:2002-05-14 00:00:00
abstract::We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.59.1.123
更新日期:2002-07-09 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Posterior cortical atrophy (PCA) is a progressive neurodegenerative syndrome that presents with cortical visual dysfunction and relatively preserved memory. Although higher cortical visual syndromes are well known in PCA, visual field defects detected by computerized visual field (CVF) perimetr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823e9f2a
更新日期:2011-12-13 00:00:00
abstract::We enrolled 11 patients with secondary progressive MS in a randomized single-masked cross-over study of plasma exchange (PE) in combination with azathioprine 2 mg/kg. PE was performed once a week for 4 weeks and thereafter every second week for 20 weeks (14 treatments). Eight patients completed the whole trial, and th...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.46.6.1620
更新日期:1996-06-01 00:00:00
abstract::Since a parental sex effect has been reported in Huntington's disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.8.1292
更新日期:1991-08-01 00:00:00
abstract::Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.32.5.547
更新日期:1982-05-01 00:00:00
abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000133122.14824.25
更新日期:2004-07-13 00:00:00
abstract::Acquired aphasia with convulsive disorder is an unusual condition in childhood, characterized by loss of language function associated with a paroxysmal electroencephalogram. To determine the course and outcome of this disorder, we evaluated nine patients 10 to 28 years after the onset of aphasia. Four patients had rec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.524
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of onabotulinumtoxinA 100 U in noncatheterizing patients with multiple sclerosis (MS) with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS:In this randomized, double-blind phase III study, patients received onabotulinumtoxinA 100 U (n = 66)...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000005991
更新日期:2018-08-14 00:00:00
abstract:OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pall...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005355
更新日期:2018-04-24 00:00:00
abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...
journal_title:Neurology
pub_type: 杂志文章,实务指引
doi:10.1212/01.wnl.0000215428.46057.3d
更新日期:2006-04-11 00:00:00
abstract:OBJECTIVE:To assess functional changes in lymphocyte repertoire and subsequent clinical implications during delayed-release dimethyl fumarate (DMF) treatment in patients with multiple sclerosis. METHODS:Using peripheral blood from several clinical trials of DMF, immune cell subsets were quantified using flow cytometry...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007262
更新日期:2019-04-09 00:00:00
abstract::Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.6.514
更新日期:1976-06-01 00:00:00
abstract::To assess the role of current weekly alcohol consumption as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. The frequency of hypertension...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.339
更新日期:1989-03-01 00:00:00
abstract::A 3-year 8-month-old girl died after 14 months of illness characterized by episodes of intermittent ataxia associated with oculomotor palsy, hypotonia, mental confusion, and disturbances of consciousness. In the last 4 months of life, there were signs of liver dysfunction. Pyruvate dehydrogenase and alpha-ketoglutarat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1578
更新日期:1979-12-01 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract::Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1417
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Previous studies link posterior border-zone cerebral infarcts between the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) to hemodynamic causes, not embolism. OBJECTIVE:To study the cause of these infarcts. METHODS:We studied 21 patients (unilateral = 18, bilateral = 3) with acute, sym...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.6.1312
更新日期:1999-10-12 00:00:00
abstract:BACKGROUND:The use of volumetric MRI as a biomarker for assessing transitions to dementia presumes that more rapid brain loss marks the clinical transition from benign aging to mild cognitive impairment (MCI). The trajectory of this volume loss relative to the timing of the clinical transition to dementia has not been ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000280577.43413.d9
更新日期:2008-03-11 00:00:00
abstract:OBJECTIVE:To investigate the association between early depressive behavior after stroke onset and occurrence of poststroke depression (PSD) at 3- and 12-month follow-up evaluations. METHODS:The study prospectively included 273 patients with first-ever single uncomplicated ischemic stroke. In the stroke unit, nurses sc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150935.05940.2D
更新日期:2005-02-08 00:00:00
abstract::Patients with frontal lobe dementia (FLD) include those who suffer from Pick's disease, corticobasal degeneration, FLD without specific histopathologic features, as well as the infrequent families with frontotemporal dementia and parkinsonism associated with chromosome 17. Currently there have been no systematic effor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.suppl_4.s41
更新日期:2001-06-01 00:00:00
abstract::Neurologic abnormalities were seen in 13 of 20 patients with a history of chronic solvent vapor (primarily toluene) abuse for 2 or more years. The patients were evaluated after an abstinence period of at least 4 weeks, to avoid neurologic effects of acute intoxication. Neurologic signs included cognitive (60%), pyrami...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.698
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000007242
更新日期:2019-04-02 00:00:00
abstract::The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 micr...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000092019.53628.88
更新日期:2003-11-11 00:00:00