Abstract:
:The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 microg for up to 24 weeks, in addition to IV immunoglobulin (IVIg). IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement.
journal_name
Neurologyjournal_title
Neurologyauthors
Pritchard J,Gray IA,Idrissova ZR,Lecky BR,Sutton IJ,Swan AV,Willison HJ,Winer JB,Hughes RAdoi
10.1212/01.wnl.0000092019.53628.88subject
Has Abstractpub_date
2003-11-11 00:00:00pages
1282-4issue
9eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
NEUROLOGY文献大全abstract::The question of the appropriate use of opiate analgesics in the management of chronic headache pain is under debate. Often, the management of headache pain is complicated by the overuse of dependency-promoting analgesics. Because of confusion about the use of analgesics in pain management, some patients are denied acc...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.315
更新日期:1984-03-01 00:00:00
abstract::Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.5_suppl_5.s31
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AE...
journal_title:Neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1212/WNL.0b013e3181a6b325
更新日期:2009-07-14 00:00:00
abstract::A 42-year-old man had progressive distal weakness and muscle atrophy, stocking-type sensory loss, upper motor-neuron and visual pathway lesions, and dysautonomia. Electrodiagnostic tests revealed a generalized sensorimotor peripheral neuropathy that largely involved axons. Low recumbent and upright norepinephrine leve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1495
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE:To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS:Ninety term neonates were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.4.542
更新日期:2002-02-26 00:00:00
abstract:BACKGROUND:Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known. METHODS:We retrospectively reviewed the medical records of 41 patients consecutively treated by PE between January 1995 and July 2007. The primary ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b879be
更新日期:2009-09-22 00:00:00
abstract::Homolateral ataxia and crural paresis is a recognized vascular syndrome. However, confirmation of the causative lesion rests principally on one earlier case with multiple other infarcts. We studied a patient with the clinical syndrome; computerized tomography revealed a lucency that appeared within 1 week of the infar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.1013
更新日期:1980-09-01 00:00:00
abstract::We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.7.710
更新日期:1978-07-01 00:00:00
abstract::Data from the Aspirin in Transient Ischemic Attack (AITIA) study, an ongoing study of two platelet antiaggregant drugs, and other published therapeutic trials were reviewed to determine whether the severity of stroke is reduced in patients taking platelet antiaggregants. Data from three of four studies suggest that st...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1212/wnl.35.5.632
更新日期:1985-05-01 00:00:00
abstract::Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.62.5_suppl_2.s17
更新日期:2004-03-09 00:00:00
abstract:OBJECTIVE:To evaluate urinary neurotrophin receptor p75 extracellular domain (p75ECD) levels as disease progression and prognostic biomarkers in amyotrophic lateral sclerosis (ALS). METHODS:The population in this study comprised 45 healthy controls and 54 people with ALS, 31 of whom were sampled longitudinally. Urinar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003741
更新日期:2017-03-21 00:00:00
abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b16
更新日期:2010-09-14 00:00:00
abstract::In muscles with sustained voluntary contraction, EMG activity is transiently inhibited after transcranial magnetic stimulation. We recorded this postexcitatory silent period (SP) at 1.5 times individual stimulus threshold level from the first dorsal interosseus muscle in 65 neurologic patients aged 11 to 80 years. Whe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.5.936
更新日期:1994-05-01 00:00:00
abstract::The forearm segment of the ulnar nerve is difficult to assess if the nerve has been injured severely at the wrist. A new, simple nerve conduction technique of recording from the sensory dorsal branch of the nerve localizes the lesion and enables easier evaluation of that segment than do other techniques. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.8.873
更新日期:1980-08-01 00:00:00
abstract::In 41 cases of verified ruptured saccular aneurysm, we prospectively predicted the presence or absence of delayed symptomatic cerebral vasospasm. CT criteria quantifying the extent and location of subarachnoid blood (developed in our previous retrospective study) were used in this prospective series of patients. Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.4.424
更新日期:1983-04-01 00:00:00
abstract::We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), San...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1901
更新日期:1992-10-01 00:00:00
abstract::We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.1927
更新日期:1993-10-01 00:00:00
abstract::Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.14
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000287
更新日期:2014-04-08 00:00:00
abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.294
更新日期:1975-03-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence suggest that pathologic changes underlying Alzheimer disease (AD) begin years prior to the clinical expression of the disease, underscoring the need for studies of cognitively healthy adults to capture these early changes. The overall goal of the current study was to map the cortical...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318245d295
更新日期:2012-02-07 00:00:00
abstract:OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1218
更新日期:2002-10-22 00:00:00
abstract::Spinal muscular atrophy (SMA) is the most common fatal neuromuscular disease of infancy. SMA type I is the most severe and mortality is usually due to respiratory failure. In type II the disability is of later onset and less severe, and prognosis has improved primarily due to supportive care. Type III is the mildest f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183282.10946.c7
更新日期:2005-11-08 00:00:00
abstract::Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.2.135
更新日期:1975-02-01 00:00:00
abstract::The endogenous auditory P300 event-related potential (P3) has been used to differentiate functional and organic cognitive disorders in adults. We found that children with organic cognitive impairments (as determined by the Halstead-Reitan [HR] test) had greater P3 latencies than children with normal HR evaluations. Th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.323
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003690
更新日期:2017-03-07 00:00:00
abstract::We previously described demyelination in the brain and subacute combined degeneration of the spinal cord in a patient with 5,10-methylenetetrahydrofolate reductase deficiency. To assess the role of methionine, S-adenosylmethionine, folate, and neurotransmitter amine metabolism in the demyelination process, we measured...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.459
更新日期:1988-03-01 00:00:00
abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000078031.32904.0d
更新日期:2003-09-09 00:00:00
abstract::We report the occurrence of neurologic complications in 23 patients who underwent gastric restriction surgery for the treatment of morbid obesity. Complications occurred 3 to 20 months after surgery. All the patients had had protracted vomiting for the first 3 months after the operation. The following syndromes were f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.196
更新日期:1987-02-01 00:00:00