Abstract:
:This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On microscopic examination, 11 patients had no thymic tissue. The other nine patients, including the one with thymectomy, all showed marked involution of the thymus. No germinal centers were seen. The thymus glands of two additional patients, still alive after thymectomy at ages 62 and 70, showed similar findings. Marked involution of the thymus also was found in each of six elderly controls. Thymectomy is not likely to be effective treatment of the elderly myasthenic patient.
journal_name
Neurologyjournal_title
Neurologyauthors
Perlo VP,Arnason B,Castleman Bdoi
10.1212/wnl.25.3.294subject
Has Abstractpub_date
1975-03-01 00:00:00pages
294-5issue
3eissn
0028-3878issn
1526-632Xjournal_volume
25pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000148649.17706.D9
更新日期:2005-01-11 00:00:00
abstract:OBJECTIVE:To examine the effects of natalizumab on low-contrast letter acuity as a prespecified tertiary endpoint in two randomized clinical trials and to evaluate the usefulness of low-contrast letter acuity testing as a candidate test of visual function in multiple sclerosis (MS). METHODS:AFFIRM and SENTINEL were ra...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000259521.14704.a8
更新日期:2007-04-17 00:00:00
abstract:OBJECTIVE:To define the clinical and radiologic features of brainstem gliomas (BSGs) in children with neurofibromatosis type 1 (NF1). METHODS:We performed a retrospective cross-sectional study of 133 children with NF1 and concurrent BSGs cared for at 4 NF1 referral centers. BSG was determined using radiographic criter...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003881
更新日期:2017-04-18 00:00:00
abstract::We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.459
更新日期:1986-04-01 00:00:00
abstract::The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065885.15875.0d
更新日期:2003-04-22 00:00:00
abstract::The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002219
更新日期:2015-12-15 00:00:00
abstract::MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000079370.28310.ea
更新日期:2003-08-26 00:00:00
abstract::We studied the interrater variability among three neurologists of the diagnosis of a seizure in 100 patients evaluated for a possible "first seizure." We found that use of simple descriptive diagnostic criteria and discussion among the neurologists themselves improved the diagnostic agreement. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.2.267
更新日期:1989-02-01 00:00:00
abstract::We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.6.891
更新日期:1990-06-01 00:00:00
abstract:OBJECTIVE:Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT). With a focus on Singapore, this analysis identifies circumstances in which ge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aac73
更新日期:2012-09-18 00:00:00
abstract::We present four patients with typical neonatal onset non-ketotic hyperglycinemia (NKH) who developed hydrocephalus requiring shunting in early infancy. Brain imaging revealed acute hydrocephalus, a megacisterna magna or posterior fossa cyst, pronounced atrophy of the white matter, and an extremely thin corpus callosum...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.3.754
更新日期:2000-02-08 00:00:00
abstract:OBJECTIVE:To determine whether patients with Alzheimer disease (AD) compensate for neuropathologic changes when performing a mnemonic task by recruiting 1) the same brain regions as age-matched, healthy controls, but to a greater extent; 2) additional brain regions not activated by controls; or 3) both. METHODS:Twelve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000237534.31734.1b
更新日期:2006-09-26 00:00:00
abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000255943.10045.c0
更新日期:2007-02-27 00:00:00
abstract::Levodopa is the most effective drug treatment for Parkinson's disease (PD). However, its chronic use is associated with dyskinesia, motor fluctuations, and hallucinations. There are various approaches to the management of levodopa complications. Motor fluctuations can be treated with a long-acting levodopa preparation...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Histologic studies show that the amygdala is affected by Alzheimer disease (AD) pathology, and its medial aspect is the most involved. We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI. METHODS:A total of 19 patients with AD (mean age 76, SD 6 ye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820d62d9
更新日期:2011-02-22 00:00:00
abstract::Proximal myotonic myopathy (PROMM) is an autosomal dominantly inherited multisystemic disorder characterized by myotonia, proximal muscle weakness, and cataracts. This disorder is not linked to the gene locus of myotonic dystrophy (DM). We describe three new families with PROMM. In all patients, CTG repeats of the DM ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.1.33
更新日期:1997-01-01 00:00:00
abstract::Fluctuations in motor response eventually affect most patients with Parkinson's disease who have been exposed to chronic, intermittent levodopa administration for longer than 5 years. Response oscillations are often related to the timing of levodopa doses (predictable "wearing-off"), but random "on-off" effects also o...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract::To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.51.2.583
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To assess the effect of usage of three different versions of Creutzfeldt-Jakob disease (CJD) diagnostic criteria on estimates of CJD incidence. METHODS:A total of 428 patients referred for suspected sporadic CJD between 1991 and 1997 were classified according to different criteria to be compared after analys...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1095
更新日期:2000-03-14 00:00:00
abstract:OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c1e44f
更新日期:2009-11-17 00:00:00
abstract::Fasciculations and cramps may occur in motor neuron disease or as part of a more benign syndrome. A man with apparently benign fasciculations and cramps for 4 years developed progressive muscle weakness and wasting. Such a previously undocumented evolution of benign fasciculations and cramps to motor neuron disease ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.7.997
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:To identify presurgical and postsurgical factors that are independently predictive of the outcome of anterior temporal lobectomy (ATL) for intractable epilepsy. BACKGROUND:There have been reports of prognostic factors in epilepsy surgery, but little is known about factors that independently predict outcome o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.2.465
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy of Neurology (AAN) guidelines. METHODS:We reviewed the charts of all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals in the Midwest United St...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000436938.70528.4a
更新日期:2013-12-03 00:00:00
abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.855
更新日期:1991-06-01 00:00:00
abstract::Management of low-grade gliomas continues to be a challenging task, because CT and MRI do not always differentiate from nontumoral lesions. Furthermore, tumor extent and aggressiveness often remain unclear because of a lack of contrast enhancement. Previous studies indicated that large neutral amino acid tracers accum...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.5.1316
更新日期:1998-05-01 00:00:00
abstract::Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.2.135
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000134665.58343.8d
更新日期:2004-09-14 00:00:00
abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824b94e9
更新日期:2012-03-06 00:00:00
abstract:OBJECTIVE:To identify the metabolic signature of the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). METHODS:A total of 170 ALS cases consecutively enrolled at the ALS Center of Turin underwent brain 18F-FDG-PET and were classified as ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002242
更新日期:2016-01-05 00:00:00
abstract:OBJECTIVE:To determine whether hippocampal neurons and choroidal epithelial cells demonstrate a mitochondrial enzyme deficiency in AD more frequently than in normal aging. BACKGROUND:High levels of mutant mitochondrial DNA (mtDNA) cause a deficiency in cytochrome c oxidase (COX) (complex IV activity) because three of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.260
更新日期:2001-07-24 00:00:00