Abstract:
:In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high or low cumulative doses of steroids did not correlate predictably with the occurrence of fractures.
journal_name
Neurologyjournal_title
Neurologyauthors
Troiano RA,Jotkowitz A,Cook SD,Bansil S,Zito Gdoi
10.1212/wnl.42.7.1389subject
Has Abstractpub_date
1992-07-01 00:00:00pages
1389-91issue
7eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142258.29304.fe
更新日期:2004-10-26 00:00:00
abstract::Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.7.1071
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVE:To detect and quantify lesions of the small-caliber sural nerve (SN) in symptomatic and asymptomatic transthyretin familial amyloid polyneuropathy (TTR-FAP) by high-resolution magnetic resonance neurography (MRN) in correlation with electrophysiologic and histopathologic findings. METHODS:Twenty-five patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004178
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345969.57574.f5
更新日期:2009-05-19 00:00:00
abstract::We examined correlates of depression in patients whose onset of Parkinson's disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). The early-onset group showed a significantly higher frequency of depression than the late-onset group. When both group...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.11.1441
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging. METHODS:Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182840bbe
更新日期:2013-03-05 00:00:00
abstract:OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.6.1246
更新日期:1999-10-12 00:00:00
abstract:OBJECTIVE:To review the disciplinary process by which the American Academy of Neurology (AAN) enforces its formalized standards of professional conduct. METHODS:We reviewed the AAN's Disciplinary Action Policy. We tracked the elapsed time from receipt to final decision of all allegations ("complaints") of improper con...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318202014e
更新日期:2010-12-14 00:00:00
abstract::To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.9.1240
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002943
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:In children with tuberous sclerosis, the PET tracer alpha[11C]methyl-L-tryptophan (AMT) has been shown to be selectively taken up by epileptogenic tubers, thus allowing differentiation from nonepileptogenic tubers in the interictal state. OBJECTIVE:To determine whether cortical areas showing increased AMT u...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000049468.05050.f2
更新日期:2003-03-25 00:00:00
abstract:OBJECTIVE:This methodologic study investigates if the 2-minute walk test (2MWT) can be a valid alternative to the 6-minute walk test (6MWT) to describe walking capability in patients with neuromuscular diseases. METHODS:Patients (n = 115) with different neuromuscular diseases were invited to participate on 2 test days...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002332
更新日期:2016-02-02 00:00:00
abstract:OBJECTIVE:To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial. METHODS:The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bila...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0000000000009946
更新日期:2020-07-28 00:00:00
abstract:OBJECTIVE:To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. METHODS:Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed b...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1212/wnl.51.6.1546
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:Small uncontrolled series suggest that treatment of obstructive sleep apnea (OSA) in patients with epilepsy may improve seizure control. Prior to conducting a definitive randomized controlled trial, we addressed critical design issues in a pilot study. METHODS:We identified a cohort of adult patients with me...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000323927.13250.54
更新日期:2008-08-19 00:00:00
abstract::The American Academy of Neurology Workforce Task Force (WFTF) report predicts a future shortfall of neurologists in the United States. The WFTF data also suggest that for most states, the current demand for neurologist services already exceeds the supply, and by 2025 the demand for neurologists will be even higher. Th...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e31829d8783
更新日期:2013-07-30 00:00:00
abstract:OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004740
更新日期:2017-12-12 00:00:00
abstract::Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In v...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.28
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327643.05073.eb
更新日期:2008-10-14 00:00:00
abstract:OBJECTIVES:To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS:This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-bl...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3181e1ce73
更新日期:2010-06-08 00:00:00
abstract::In this double-blind, placebo-controlled trial, we investigated the effect of the catechol-O-methyltransferase inhibitor tolcapone 100 or 200 mg three times daily on activities of daily living and motor function in 298 patients with parkinsonism receiving levodopa but without motor fluctuations. At 6 months, both dosa...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.49.3.665
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Posterior cortical atrophy (PCA) is a progressive dementia characterized by prominent disorders of higher visual processing, affecting both dorsal and ventral streams to cause Balint's syndrome, alexia, and visual agnosia. OBJECTIVE:To define the cognitive profile of PCA and compare to the typical, primary ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000196477.78548.db
更新日期:2006-02-14 00:00:00
abstract::Wolfram syndrome is an autosomal recessive disorder beginning in childhood that consists of four cardinal features: optic atrophy, diabetes mellitus, diabetes insipidus, and neurosensory hearing loss. Aside from these features, the clinical picture is highly variable and may include other neurologic abnormalities such...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.6.1220
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD). METHODS:We analyzed 201 consecutive patients with acute infarcts withi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824c4699
更新日期:2012-03-20 00:00:00
abstract::Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.8.912
更新日期:1982-08-01 00:00:00
abstract::Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyryl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000068336.84399.9e
更新日期:2003-06-10 00:00:00
abstract:BACKGROUND:We previously studied the occurrence of muscle tone reduction (MTR), sawtooth waves (STW), and REM in sleep, and found a stereotypical sequence of these events in normal subjects. Patients with the postpolio syndrome may have involvement of the reticular formation in the brainstem, an area known to mediate i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.3.516
更新日期:1999-02-01 00:00:00
abstract::Pearson syndrome is a systemic disorder of oxidative phosphorylation in infants, predominantly affecting the bone marrow and exocrine pancreas and associated with single deletions in mitochondrial DNA (mtDNA). CNS involvement may occur in patients who survive the infantile hematopoietic disorder. We describe a Pearson...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1320
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the predictive utility of self-reported and informant-reported functional deficits in patients with mild cognitive impairment (MCI) for the follow-up diagnosis of probable AD. METHODS:The Pfeffer Functional Activities Questionnaire (FAQ) and Lawton Instrumental Activities of Daily Living (IADL) S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.758
更新日期:2002-03-12 00:00:00
abstract:BACKGROUND:Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease METHODS:The authors analyzed the levels of various CSF biomarkers in 27 patients with MSA-C and 18 patients with IL...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000227891.25592.8c
更新日期:2006-08-08 00:00:00