Abstract:
:Wolfram syndrome is an autosomal recessive disorder beginning in childhood that consists of four cardinal features: optic atrophy, diabetes mellitus, diabetes insipidus, and neurosensory hearing loss. Aside from these features, the clinical picture is highly variable and may include other neurologic abnormalities such as ataxia, nystagmus, mental retardation, and seizures. We present two unrelated patients with Wolfram syndrome, both of whom had the four cardinal features and several other neurologic abnormalities. MRIs showed widespread atrophic changes throughout the brain, some of which correlated with the major neurologic features of the syndrome.
journal_name
Neurologyjournal_title
Neurologyauthors
Rando TA,Horton JC,Layzer RBdoi
10.1212/wnl.42.6.1220subject
Has Abstractpub_date
1992-06-01 00:00:00pages
1220-4issue
6eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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