Abstract:
:Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In view of these findings, we undertook a systematic search for autonomously proliferating cells in the spinal fluids of MS patients and those with other neurologic diseases (OND). In vivo activated blast cells were isolated from the CSF of six MS patients and six OND controls. A total of 442 clones were grown from these cells and assayed for their ability to proliferate independently, without the need for T cell-produced lymphokines. No autonomously proliferating clones were detected. Thus, while our data do not exclude the possibility that HTLV I transformed cells may exist in the CSF of MS patients, they do suggest that such cells are exceptional.
journal_name
Neurologyjournal_title
Neurologyauthors
Birnbaum G,Aubitz S,Kotilinek Ldoi
10.1212/wnl.38.1.28subject
Has Abstractpub_date
1988-01-01 00:00:00pages
28-30issue
1eissn
0028-3878issn
1526-632Xjournal_volume
38pub_type
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