Abstract:
:Ten patients with amyotrophic lateral sclerosis were given intrathecal injections of natural interferon alpha, 1 million units weekly for 7 to 24 weeks. Six patients completed the trial. Four voluntarily withdrew after 7 to 13 injections. The slopes of deterioration for 40 quantitative tests of neuromuscular function for the control and treatment periods were compared by paired t test in the six patients who completed the trial and in the patient who withdrew after 13 injections. No significant differences were found. The patients tolerated treatment well. The CSF reaction was modest and spontaneously reversible. Indomethacin and ibuprofen blocked interferon side effects.
journal_name
Neurologyjournal_title
Neurologyauthors
Mora JS,Munsat TL,Kao KP,Finison LJ,Hedlund W,Bradley GA,Scheife R,Georgiades JAdoi
10.1212/wnl.36.8.1137subject
Has Abstractpub_date
1986-08-01 00:00:00pages
1137-40issue
8eissn
0028-3878issn
1526-632Xjournal_volume
36pub_type
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