Abstract:
:After superficial temporal artery-middle cerebral artery bypass, cerebral blood flow (CBF) in the operated hemisphere increased in 6 of 17 patients. Preoperatively, the symptomatic hemisphere showed lower CBF in all six, lower oxygen metabolism in five, higher blood volume in four, and higher oxygen extraction in two. With the postoperative increase in hemispheric CBF, there was a decrease in oxygen extraction, but no change in blood volume or oxygen metabolism. In these patients, chronic regional hypoperfusion followed major vascular occlusion. Compensatory responses included dilation of intraparenchymal vessels and increased transport of oxygen from blood to tissue. These changes were partially reversed by cerebral revascularization.
journal_name
Neurologyjournal_title
Neurologyauthors
Powers WJ,Martin WR,Herscovitch P,Raichle ME,Grubb RL Jrdoi
10.1212/wnl.34.9.1168subject
Has Abstractpub_date
1984-09-01 00:00:00pages
1168-74issue
9eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000007452
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To determine the risk of seizure recurrence after a first seizure due to neurocysticercosis (NC) and to evaluate risk factors for seizure recurrence, including the influence of antihelminthic treatment. METHODS:The authors prospectively followed 77 patients with a first seizure and active or transitional NC ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000036320.69823.ea
更新日期:2002-12-10 00:00:00
abstract::Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.WNL.0000149527.47600.5A
更新日期:2005-01-25 00:00:00
abstract:OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318253d62f
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the extent of leukoaraiosis, a composite marker of baseline brain integrity, differed between patients with TIA with diffusion-weighted imaging (DWI) evidence of infarction (transient symptoms with infarction [TSI]) and patients with ischemic stroke. METHODS:Leukoaraiosis volume on MRI w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318221ad02
更新日期:2011-07-05 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182050225
更新日期:2011-01-04 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies. METHODS:In a randomized, double-blind study, patients with HIV-associated distal sensory polyneuropathy (DSP) received LTG or placebo during a 7-week dose escalation phase followed...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000063304.88470.d9
更新日期:2003-05-13 00:00:00
abstract:OBJECTIVE:To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population. METHODS:The authors assessed CH as defined by the second edition of the International Classification of Headache Disorders in 31,750 registered twins born fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000233786.72356.3e
更新日期:2006-09-12 00:00:00
abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0fa1
更新日期:2013-01-29 00:00:00
abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.47.3.785
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To investigate whether dietary patterns (Mediterranean diet [MedDiet], Dietary Approaches to Stop Hypertension [DASH], and A Priori Diet Quality Score [APDQS]) during adulthood are associated with midlife cognitive performance. METHODS:We studied 2,621 Coronary Artery Risk Development in Young Adults (CARDIA...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007243
更新日期:2019-04-02 00:00:00
abstract::Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management is changing the approach to stroke patients. The development process has been difficult and the current treatment recommendations have been controversial. Rece...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.53.1.14
更新日期:1999-07-13 00:00:00
abstract:OBJECTIVE:To clarify the clinical and neurophysiologic spectrum of myoclonus-dystonia patients with mutations of the SGCE gene. METHODS:We prospectively studied 41 consecutive patients from 22 families with documented mutations of the SGCE gene. The patients had a standardized interview, neurologic examination, and de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000297516.98574.c0
更新日期:2008-03-25 00:00:00
abstract::The syndrome of increased intracranial pressure without hydrocephalus or mass lesion and with normal CSF composition, previously referred to as pseudotumor cerebri, is a diagnosis of exclusion now termed idiopathic intracranial hypertension (IIH). Diagnostic criteria of this disorder have not been updated since the Mo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000029570.69134.1b
更新日期:2002-11-26 00:00:00
abstract::Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000004977
更新日期:2018-02-06 00:00:00
abstract:OBJECTIVE:In children with and without infantile spasms, this study determined brain volumes and cell densities in epilepsy surgery patients with tuberous sclerosis complex (TSC) and cortical dysplasia with balloon cells (CD). METHODS:We compared TSC (n = 18) and CD (n = 17) patients with normal/autopsy controls (n = ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252952.62543.20
更新日期:2007-02-06 00:00:00
abstract::Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031430.40085.93
更新日期:2002-11-12 00:00:00
abstract::Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.1.30
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS:Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS:Speech w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003635
更新日期:2017-02-21 00:00:00
abstract::Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.126
更新日期:1980-02-01 00:00:00
abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000234141.72891.13
更新日期:2006-09-12 00:00:00
abstract::The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.6.780
更新日期:1979-06-01 00:00:00
abstract::The minimum exposure to estrogen required to cause estrogen-withdrawal migraine has been studied by giving long-acting estradiol valerate to four women and short-acting estradiol benzoate to two women. It was found that several days of exposure to high estrogen levels were needed to cause migraine on estrogen withdraw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.239
更新日期:1975-03-01 00:00:00
abstract::A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.296
更新日期:1998-01-01 00:00:00
abstract::Three sisters with adult fucosidosis showed prominent psychomotor retardation, gargoyle features, and angiokeratoma corporis diffusum, meeting the criteria for type II fucosidosis. By histochemical and ultrastructural studies, biopsy of rectal mucosa revealed many abnormal macrophages that were filled with fucose-rich...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.4.451
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE:To determine (1) if mortality among patients with idiopathic intracranial hypertension (IIH) enrolled in the Intracranial Hypertension Registry (IHR) is different from that of the general population of the United States and (2) what the leading underlying causes of death are among this cohort. METHODS:Mortal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009312
更新日期:2020-08-18 00:00:00
abstract:OBJECTIVE:To provide a comprehensive understanding of APOE ε4 effects across the lifespan on the 3 main neuroimaging biomarkers. METHODS:Two hundred seven community-dwelling, cognitively normal APOE ε4 carriers and noncarriers aged 20-87 years were involved in this study. They underwent structural MRI, fluorodeoxygluc...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0000000000003234
更新日期:2016-10-18 00:00:00
abstract:OBJECTIVES:Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. METHODS:Between 2005 and 2007, survivors o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aacd4
更新日期:2012-09-18 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000267430.95106.ff
更新日期:2007-08-14 00:00:00
abstract:OBJECTIVE:To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom. METHODS:Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and Decembe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010171
更新日期:2020-09-01 00:00:00