Abstract:
:Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1, 2, 3, 4, 6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or triads. Leptomeres were also noted in some myotubes. By 4 weeks, cross-striation of myofilaments and migration of muscle nuclei to the periphery were observed. Distended sarcoplasmic reticulum and honeycomb structures of tubules were noted between 4 and 8 weeks. This study indicates that mature human muscle can be transplanted successfully into nude mice, providing another tool for the investigation of human neuromuscular disease.
journal_name
Neurologyjournal_title
Neurologyauthors
Wakayama Y,Schotland DL,Bonilla Edoi
10.1212/wnl.30.7.740subject
Has Abstractpub_date
1980-07-01 00:00:00pages
740-8issue
7 Pt 1eissn
0028-3878issn
1526-632Xjournal_volume
30pub_type
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