Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies.

abstract：:Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...

journal_title：Neurology

authors： Landau WM,Torack RM,Guggenheim MA

更新日期：1976-09-01 00:00:00

abstract：:The authors describe a case of syphilitic amyotrophy in a 37-year-old man presenting with subacute progressive painless weakness in the right arm. Syphilitic amyotrophy is still an existing differential diagnosis of painless and progressive weakness. The authors explore potential obstacles in the diagnostic workup and...

journal_title：Neurology

authors： Etgen T,Bischoff C,Resch M,Winbeck K,Conrad B,Sander D

更新日期：2003-02-11 00:00:00

abstract：:We report the clinical and neuroimaging findings of a mother and daughter with seizure disorders and band heterotopias seen on magnetic resonance imaging studies. These clinicoradiologic findings simulate those for a diagnosis of tuberous sclerosis complex. Clinicians should be aware of this migrational anomaly and it...

journal_title：Neurology

authors： DiMario FJ Jr,Cobb RJ,Ramsby GR,Leicher C

更新日期：1993-07-01 00:00:00

abstract：:Trigeminal neuralgia is an uncommon but troublesome symptom of multiple sclerosis that can be refractory to conventional treatments. Misoprostol, a long-acting prostaglandin E1 analogue, relieved pain in six of seven patients who had failed to respond to conventional pharmacologic therapy. ...

journal_title：Neurology

authors： Reder AT,Arnason BG

更新日期：1995-06-01 00:00:00

abstract：:We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...

journal_title：Neurology

authors： Jeerakathil TJ,Kirk A

更新日期：1994-04-01 00:00:00

abstract：:To assess reversibility of focal cerebral ischemia, we performed a neurologic and pathologic study of 27 monkeys subjected to temporary middle cerebral artery occlusion. An implanted snare ligature occluded the artery in awake monkeys for 30 minutes, 4 hours, 8 hours, 16 hours, 24 hours, or permanently. Serial neurolo...

journal_title：Neurology

authors： Crowell RM,Marcoux FW,DeGirolami U

更新日期：1981-10-01 00:00:00

abstract：:Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilo...

journal_title：Neurology

authors： Barboriak DP,Doraiswamy PM,Krishnan KR,Vidyarthi S,Sylvester J,Charles HC

更新日期：2000-06-13 00:00:00

abstract：OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...

journal_title：Neurology

authors： Helzner EP,Scarmeas N,Cosentino S,Tang MX,Schupf N,Stern Y

更新日期：2008-11-04 00:00:00

abstract：OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...

journal_title：Neurology

authors： Alves G,Wentzel-Larsen T,Larsen JP

更新日期：2004-11-23 00:00:00

abstract：:In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. We employed 14 outcome measures to assess functional and cognitive impairment. After 1...

journal_title：Neurology

authors： Spagnoli A,Lucca U,Menasce G,Bandera L,Cizza G,Forloni G,Tettamanti M,Frattura L,Tiraboschi P,Comelli M

更新日期：1991-11-01 00:00:00

abstract：:Hypohidrosis predisposes to hyperthermia and may indicate generalized thermoregulatory failure. To assess the sweating capacity in human poikilothermia, we performed a quantitative analysis of the central and peripheral sudomotor pathways in four women with acquired poikilothermia (aged 29 to 38 years) and nine contro...

journal_title：Neurology

authors： MacKenzie MA,Schönbaum E,Hermus AR,Wollersheim HC,Thien T,Smals AG,Kloppenborg PW

更新日期：1995-08-01 00:00:00

abstract：:We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of p...

journal_title：Neurology

authors： Bendixen BH,Younger DS,Hair LS,Gutierrez C,Meyers ML,Homma S,Jaffe IA

更新日期：1992-02-01 00:00:00

abstract：:The clinical and angiographic correlations of small deep infarcts seen on computed tomography (CT) scan were studied in 297 consecutive patients. Some of these showed the features described by Fisher as part of the lacunar syndrome. In a large number, a source of emboli from either a cardiac or a carotid source was hi...

journal_title：Neurology

authors： Pullicino P,Nelson RF,Kendall BE,Marshall J

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of oral anticoagulants vs antiplatelets in patients with stroke and atherosclerotic plaques in the aortic arch or cervical or intracranial arteries, collectively described as supracardiac atherosclerosis. METHODS:We searched PubMed and Scopus until August 28, 2019, for rand...

journal_title：Neurology

authors： Sagris D,Georgiopoulos G,Leventis I,Pateras K,Pearce LA,Korompoki E,Makaritsis K,Vemmos K,Milionis H,Ntaios G

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this is...

journal_title：Neurology

authors： Robert GH,Le Jeune F,Lozachmeur C,Drapier S,Dondaine T,Péron J,Houvenaghel JF,Travers D,Sauleau P,Millet B,Vérin M,Drapier D

更新日期：2014-10-28 00:00:00

abstract：:This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5...

journal_title：Neurology

authors： Chan CH

更新日期：1990-09-01 00:00:00

abstract：:The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...

journal_title：Neurology

authors： Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss AL

更新日期：2001-04-10 00:00:00

abstract：OBJECTIVE:To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. METHODS:The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, res...

journal_title：Neurology

authors： Siegel AM,Cascino GD,Meyer FB,McClelland RL,So EL,Marsh WR,Scheithauer BW,Sharbrough FW

更新日期：2004-12-28 00:00:00

abstract：OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...

journal_title：Neurology

authors： Madsen KL,Buch AE,Cohen BH,Falk MJ,Goldsberry A,Goldstein A,Karaa A,Koenig MK,Muraresku CC,Meyer C,O'Grady M,Scaglia F,Shieh PB,Vockley J,Zolkipli-Cunningham Z,Haller RG,Vissing J

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVE:To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP). METHODS:A total of 288 professional hockey players ...

journal_title：Neurology

authors： Shahim P,Tegner Y,Marklund N,Blennow K,Zetterberg H

更新日期：2018-05-15 00:00:00

abstract：:The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infar...

journal_title：Neurology

authors： van der Worp HB,Kappelle LJ,Algra A,Bär PR,Orgogozo JM,Ringelstein EB,Bath PM,van Gijn J,TESS Investigators.,TESS II Investigators.

更新日期：2002-01-08 00:00:00

abstract：:The authors report eight patients with primary dural lymphoma (PDL). All patients had extra-axial masses on MRI that diffusely enhanced after gadolinium. Pathology revealed low-grade non-Hodgkin lymphoma (marginal zone lymphoma of MALT [mucosa-associated lymphoid tissue] type) in all patients. All patients underwent r...

journal_title：Neurology

authors： Iwamoto FM,DeAngelis LM,Abrey LE

更新日期：2006-06-13 00:00:00

abstract：:Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but ...

journal_title：Neurology

authors： García-Larrea L,Artru F,Bertrand O,Pernier J,Mauguière F

更新日期：1988-09-01 00:00:00

abstract：:In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked de...

journal_title：Neurology

authors： Goto S,Matsumoto S,Ushio Y,Hirano A

更新日期：1996-10-01 00:00:00

abstract：:Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; mot...

journal_title：Neurology

authors： Wolf SM,Wagner JH,Davidson S,Forsythe A

更新日期：1978-02-01 00:00:00

abstract：:The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...

journal_title：Neurology

authors： Dodson WE

更新日期：1980-02-01 00:00:00

abstract：:Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

journal_title：Neurology

authors： Spector RH,Fiandaca MS

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:Histologic studies show that the amygdala is affected by Alzheimer disease (AD) pathology, and its medial aspect is the most involved. We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI. METHODS:A total of 19 patients with AD (mean age 76, SD 6 ye...

journal_title：Neurology

authors： Cavedo E,Boccardi M,Ganzola R,Canu E,Beltramello A,Caltagirone C,Thompson PM,Frisoni GB

更新日期：2011-02-22 00:00:00

abstract：:In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...

journal_title：Neurology

authors： Diederich N,Goetz CG,Stebbins GT,Klawans HL,Nittner K,Koulosakis A,Sanker P,Sturm V

更新日期：1992-07-01 00:00:00

abstract：:Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...

journal_title：Neurology

authors： Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

更新日期：1987-12-01 00:00:00