Oligodendrocyte-binding antibodies in multiple sclerosis: 125I-protein A studies.

Abstract:

:Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocytes was similar in MS and non-MS sera, but both were significantly higher than binding in controls. A hundredfold increase of 125I-protein A binding over the preimmune value was obtained with a rabbit antioligodendrocyte antiserum. Oligodendrocyte-binding antibodies measured with 125I-protein A do not appear to be a distinctive feature of MS.

journal_name

Neurology

journal_title

Neurology

authors

Steck AJ,Regli F

doi

10.1212/wnl.30.5.540

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

540-2

issue

5

eissn

0028-3878

issn

1526-632X

journal_volume

30

pub_type

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