Abstract:
:The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2R and in none of 6 patients with preserved reactivity (p = 0.011). Abnormal CO2R preceded the onset of vasospasm in 7 of 9 patients. Abnormal standard TCD testing was not associated with vasospasm.
journal_name
Neurologyjournal_title
Neurologyauthors
Frontera JA,Rundek T,Schmidt JM,Claassen J,Parra A,Wartenberg KE,Temes RE,Mayer SA,Mohr JP,Marshall RSdoi
10.1212/01.wnl.0000200777.96896.3dsubject
Has Abstractpub_date
2006-03-14 00:00:00pages
727-9issue
5eissn
0028-3878issn
1526-632Xpii
01.wnl.0000200777.96896.3djournal_volume
66pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To determine the effect of interferon-beta-1b (IFNbeta-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly MRI. METHODS:An open-label baseline-vs-treatment cross...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000113765.75855.19
更新日期:2004-03-09 00:00:00
abstract:OBJECTIVE:To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm. METHODS:The authors performed a retrospective evaluation of patient data obtained during presurgical evaluation, with additional CSF analyses, serum analyses, and histopathologic investigations. RESULTS:The...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.12.1823
更新日期:2000-12-26 00:00:00
abstract:OBJECTIVE:To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). METHODS:A cross-sectional Internet-based physician survey of MS specialists was performed. RESULTS:The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported h...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318259e1b2
更新日期:2012-06-12 00:00:00
abstract::A veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. Identification, isol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.1.67
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002525
更新日期:2016-03-29 00:00:00
abstract::To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.718
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence. METHODS:Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000158328.26897.0D
更新日期:2005-04-26 00:00:00
abstract:OBJECTIVE:To determine (1) if mortality among patients with idiopathic intracranial hypertension (IIH) enrolled in the Intracranial Hypertension Registry (IHR) is different from that of the general population of the United States and (2) what the leading underlying causes of death are among this cohort. METHODS:Mortal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009312
更新日期:2020-08-18 00:00:00
abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...
journal_title:Neurology
pub_type: 评论,社论
doi:10.1212/WNL.0b013e31827b9305
更新日期:2013-01-08 00:00:00
abstract::We studied 13 patients with severe drug-induced parkinsonism (DIP) using L-6-[18F]fluorodopa positron emission tomography (18F-dopa PET) to investigate the integrity of their dopaminergic nigrostriatal projections. Twelve of these patients were subsequently followed clinically for a median of 23.5 months (range, 6 to ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.3_part_1.552
更新日期:1993-03-01 00:00:00
abstract::Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.530
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the association between spinal cord injury (SCI) and type 2 diabetes in a large representative sample and to determine whether an association exists irrespective of known risk factors for type 2 diabetes. METHODS:Data were obtained on 60,678 respondents to the Stat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436074.98534.6e
更新日期:2013-11-19 00:00:00
abstract:BACKGROUND:Attempts at cell-based dopamine replacement therapy in Parkinson disease (PD) have included surgical implantation of adrenal medullary, fetal mesencephalic, and cultured human mesencephalic tissue grafts. Trials involving putamenal implantation of human retinal pigment epithelial (RPE) cells in PD have also ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bbff1c
更新日期:2009-10-06 00:00:00
abstract::We measured plasma norepinephrine levels in patients with familial amyloid polyneuropathy. Patients with orthostatic hypotension had low basal plasma norepinephrine levels, which did not increase after postural change. On the basis of biochemical findings that suggest depletion of peripheral norepinephrine, DL-threo-3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1323
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:To describe the results of a multicenter study that validated two new patient-reported measures of neurologic impairment and disability for use in MS clinical research. BACKGROUND:Self-reported data can provide a cost-effective means to assess patient functioning, and can be useful for screening patients who...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.52.1.63
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. METHODS:A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed up prospectively for 17 years. The cumulative incidence of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009917
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional training (CT) in the subacute phase after stroke. METHODS:In this randomized, controlled, single-blind phase III multicenter trial, 120 participants with upper extremity motor impairment ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000004744
更新日期:2017-12-12 00:00:00
abstract:OBJECTIVE:To assess the effects of the modified amino acid acetyl-dl-leucine (AL) on cerebellar ataxia, eye movements, and quality of life of patients with Niemann-Pick type C (NP-C) disease. METHODS:Twelve patients with NP-C disease were treated with AL 3 g/d for 1 week and then with 5 g/d for 3 weeks with a subseque...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002041
更新日期:2015-10-20 00:00:00
abstract::We have discovered a new Italian pedigree with autosomal-dominant ALS. The pedigree, at present, comprises 75 members distributed in five generations. ALS was diagnosed in eight patients. The mean +/- SD age of onset of the disease was 46.8 +/- 13.5 years, with a range of 29 to 63 years. The mean +/- SD duration of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.2.347
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:To further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS). METHODS:We compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled). RESULT...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006367
更新日期:2018-10-16 00:00:00
abstract:OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000008861
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/METHODS:We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. I...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1795
更新日期:1998-06-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract::T lymphocytes may play a central role in MS. The search for more targeted immunosuppression than is currently available has led to recent clinical trials of novel therapeutics. We studied 29 patients in a double-blind placebo-controlled trial of the chimeric monoclonal anti-CD4 antibody, cM-T412 (Centocor, Leiden, Hol...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.48.4.810
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To assess the predominant type of cerebral small vessel disease (SVD) and recurrence risk in patients who present with a combination of lobar and deep intracerebral hemorrhage (ICH)/microbleed locations (mixed ICH). METHODS:Of 391 consecutive patients with primary ICH enrolled in a prospective registry, 75 (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004797
更新日期:2018-01-09 00:00:00
abstract::Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.8.912
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND:Cerebral lateralization has been postulated to affect immunomodulation. Differenti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1183
更新日期:1999-04-12 00:00:00
abstract::A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. In the eight subjects studied, a notable clinical feature is slow progression, with the three least affected having only a mild degree of gait ataxia after three or more ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.10.1913
更新日期:2001-11-27 00:00:00
abstract::We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.38
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. METHODS:The auth...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000191403.95453.6a
更新日期:2006-01-10 00:00:00