Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease.

abstract：OBJECTIVE:To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures. METHODS:This was a multicenter,...

journal_title：Neurology

authors： French JA,Krauss GL,Biton V,Squillacote D,Yang H,Laurenza A,Kumar D,Rogawski MA

更新日期：2012-08-07 00:00:00

abstract：:The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...

journal_title：Neurology

authors： Elenberger J,Kim B,de Castro-Abeger A,Rex TS

更新日期：2020-11-03 00:00:00

abstract：OBJECTIVE:To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls. METHODS:A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 1...

journal_title：Neurology

authors： Frosch OH,Yau PL,Osorio RS,Rusinek H,Storey P,Convit A

更新日期：2017-07-18 00:00:00

abstract：:Machado-Joseph disease is a dominantly inherited, multisystem, degenerative disorder that lacks a proven genetic marker. Peripheral nerve conduction-refractory period, sensory evoked potentials, and quantified oculomotor recordings were studied in nine patients affected with this disease to look for a potential physio...

journal_title：Neurology

authors： Hotson JR,Langston EB,Louis AA,Rosenberg RN

更新日期：1987-01-01 00:00:00

abstract：:The P3 component of the auditory evoked potential has been shown to reflect "endogenous" processes related to cognition. This component was measured serially in seven patients who had confusional states or dementing illnesses that fluctuated in severity over time. The latency of P3 component reflected the clinical imp...

journal_title：Neurology

authors： Goodin DS,Starr A,Chippendale T,Squires KC

更新日期：1983-09-01 00:00:00

abstract：:Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...

journal_title：Neurology

authors： Belafsky MA,Rosman NP,Miller P,Waddell G,Boxley-Johnson J,Delgado-Escueta AV

更新日期：1978-03-01 00:00:00

abstract：:The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cog...

journal_title：Neurology

authors： Schatz J,Brown RT,Pascual JM,Hsu L,DeBaun MR

更新日期：2001-04-24 00:00:00

abstract：:The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

journal_title：Neurology

authors： Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

更新日期：1988-08-01 00:00:00

abstract：:To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR Glucose Controller. Comparison of neurologic assessm...

journal_title：Neurology

authors： Service FJ,Daube JR,O'Brien PC,Dyck PJ

更新日期：1981-11-01 00:00:00

abstract：:The authors report eight patients with primary dural lymphoma (PDL). All patients had extra-axial masses on MRI that diffusely enhanced after gadolinium. Pathology revealed low-grade non-Hodgkin lymphoma (marginal zone lymphoma of MALT [mucosa-associated lymphoid tissue] type) in all patients. All patients underwent r...

journal_title：Neurology

authors： Iwamoto FM,DeAngelis LM,Abrey LE

更新日期：2006-06-13 00:00:00

abstract：:An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic ...

journal_title：Neurology

authors： Anderson NE,Budde-Steffen C,Wiley RG,Thurman L,Rosenblum MK,Nadeau SE,Posner JB

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...

journal_title：Neurology

authors： Ferreira JJ,Lees AJ,Poewe W,Rascol O,Rocha JF,Keller B,Soares-da-Silva P

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. OBJECTIVE:To investigate whether these Gulf War-related symptoms were associated with objective evidence of neuromuscular dysfunction. METHODS:Forty-nine Gulf War veterans with more than four neu...

journal_title：Neurology

authors： Sharief MK,Priddin J,Delamont RS,Unwin C,Rose MR,David A,Wessely S

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...

journal_title：Neurology

authors： Simon JH,Jacobs LD,Campion MK,Rudick RA,Cookfair DL,Herndon RM,Richert JR,Salazar AM,Fischer JS,Goodkin DE,Simonian N,Lajaunie M,Miller DE,Wende K,Martens-Davidson A,Kinkel RP,Munschauer FE 3rd,Brownscheidle CM

更新日期：1999-07-13 00:00:00

abstract：OBJECTIVES:To determine the relative utility of 1H MRSI and hippocampal volumetry for the lateralization of mesial temporal lobe epilepsy (MTLE) in patients with intractable epilepsy. BACKGROUND:MTLE is the most common partial-onset seizure disorder in patients undergoing temporal lobe epilepsy surgery. MR volumetry a...

journal_title：Neurology

authors： Kuzniecky R,Hugg JW,Hetherington H,Butterworth E,Bilir E,Faught E,Gilliam F

更新日期：1998-07-01 00:00:00

abstract：:Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shed...

journal_title：Neurology

authors： Burger D,Dayer JM

更新日期：1995-06-01 00:00:00

abstract：:We made phenotypic analysis of 14 families with spinal muscular atrophy (SMA) linking to chromosome 5q11.2-13.3 (SMA 5q), and 2 that may not map to this locus, to assess clinical symptoms among SMA families known to result from mutation at the identical gene/locus. Although the current number of families is still smal...

journal_title：Neurology

authors： Munsat TL,Skerry L,Korf B,Pober B,Schapira Y,Gascon GG,al-Rajeh SM,Dubowitz V,Davies K,Brzustowicz LM

更新日期：1990-12-01 00:00:00

abstract：:We observed that patients with amnesia after cardiac arrest had preserved recognition memory despite profound loss of recall memory. In the present study, rate of forgetting was measured in six amnesic subjects for both recall and recognition memory of verbal material. The data show that recall decayed significantly f...

journal_title：Neurology

authors： Volpe BT,Holtzman JD,Hirst W

更新日期：1986-03-01 00:00:00

abstract：:A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...

journal_title：Neurology

authors： Torch WC,Hirano A,Solomon S

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration ...

journal_title：Neurology

authors： Jack CR Jr,Wiste HJ,Knopman DS,Vemuri P,Mielke MM,Weigand SD,Senjem ML,Gunter JL,Lowe V,Gregg BE,Pankratz VS,Petersen RC

更新日期：2014-05-06 00:00:00

abstract：OBJECTIVES:Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated in a postmortem study to indicate brain iron accumulation in a quantitative manner. We used this technique to assess brain iron levels in di...

journal_title：Neurology

authors： Khalil M,Langkammer C,Ropele S,Petrovic K,Wallner-Blazek M,Loitfelder M,Jehna M,Bachmaier G,Schmidt R,Enzinger C,Fuchs S,Fazekas F

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To study the impact of negative expectation related to receiving a placebo (the "lessebo effect") on efficacy outcome measures of symptomatic treatments in Parkinson disease (PD). METHODS:We conducted meta-analyses of double-blind randomized controlled trials (RCTs) of dopamine agonists in PD and compared th...

journal_title：Neurology

authors： Mestre TA,Shah P,Marras C,Tomlinson G,Lang AE

更新日期：2014-04-22 00:00:00

abstract：:Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...

journal_title：Neurology

authors： Carr DB,Gray S,Baty J,Morris JC

更新日期：2000-12-12 00:00:00

abstract：OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...

journal_title：Neurology

authors： Alves G,Wentzel-Larsen T,Larsen JP

更新日期：2004-11-23 00:00:00

abstract：OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...

journal_title：Neurology

authors： Bower JH,Maraganore DM,Peterson BJ,McDonnell SK,Ahlskog JE,Rocca WA

更新日期：2003-05-27 00:00:00

abstract：:To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...

journal_title：Neurology

authors： Wilson JM,Levey AI,Rajput A,Ang L,Guttman M,Shannak K,Niznik HB,Hornykiewicz O,Pifl C,Kish SJ

更新日期：1996-09-01 00:00:00

abstract：:A marked decrease in the amplitude of the evoked thenar compound muscle action potential followed brief exercise at room temperature in two patients with paramyotonia congenita. This decline was more rapid and pronounced in our patient with coexistent thyrotoxicosis. The prolonged recovery period in paramyotonia conge...

journal_title：Neurology

authors： Gutmann L,Riggs JE,Brick JF

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Bee sting therapy is increasingly used to treat patients with multiple sclerosis (MS) in the belief that it can stabilize or ameliorate the disease. However, there are no clinical studies to justify its use. METHODS:In a randomized, crossover study, we assigned 26 patients with relapsing-remitting or relaps...

journal_title：Neurology

authors： Wesselius T,Heersema DJ,Mostert JP,Heerings M,Admiraal-Behloul F,Talebian A,van Buchem MA,De Keyser J

更新日期：2005-12-13 00:00:00

abstract：:We have used computerized tomography (CT) to look for evidence of cerebral demyelination in children with progressive neurologic disorders. Fourteen patients with a clinical diagnosis of a demyelinating disorder were examined by CT, and five had CT findings suggesting cerebral demyelination. In two patients with a so-...

journal_title：Neurology

authors： Robertson WC Jr,Gomez MR,Reese DF,Okazaki H

更新日期：1977-09-01 00:00:00

abstract：:We compared MRI and CT in a study of 175 patients; 87 infarcts within a week, 40 from 1 to 40 weeks, 25 a year after onset, and 23 hemorrhages, 18 within 2 weeks and 5 in 4 to 8 weeks. Fifty-nine infarcts and eight hemorrhages had sequential scanning. MRI is more sensitive than CT in the early detection of cerebral in...

journal_title：Neurology

authors： Kertesz A,Black SE,Nicholson L,Carr T

更新日期：1987-10-01 00:00:00