Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms.

Abstract:

:The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms include anxiety, depression, sleep problems, headaches, light sensitivity, and difficulty reading. The root cause for these symptoms is under investigation by many in the field. Of interest, several of these symptoms such as headaches, ocular pain, light sensitivity, and sleep disturbances may overlap and share underlying circuitry influenced by the intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells are light sensing, but non-image forming, and they influence corneal function, pupillary constriction, and circadian rhythm. In this review, we discuss these symptoms and propose a role of the ipRGCs as at least one underlying and unifying cause for such symptoms.

journal_name

Neurology

journal_title

Neurology

authors

Elenberger J,Kim B,de Castro-Abeger A,Rex TS

doi

10.1212/WNL.0000000000010830

subject

Has Abstract

pub_date

2020-11-03 00:00:00

pages

826-833

issue

18

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000010830

journal_volume

95

pub_type

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