Initiating treatment for idiopathic parkinsonism.

abstract：OBJECTIVE:To describe the effects of the anti-tumor necrosis factor neutralizing antibody, infliximab, and the antiproliferative immunosuppressant, mycophenolate mofetil, in refractory neurosarcoidosis. METHODS:We treated patients with biopsy-proven sarcoidosis and CNS involvement, who had failed treatment with steroi...

journal_title：Neurology

authors： Moravan M,Segal BM

更新日期：2009-01-27 00:00:00

abstract：:Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. The purpose of this study was to (1) develop a statistical correction for effects of age and education and (2) test the efficacy of the statistically adjusted ...

journal_title：Neurology

authors： Mungas D,Marshall SC,Weldon M,Haan M,Reed BR

更新日期：1996-03-01 00:00:00

abstract：:Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...

journal_title：Neurology

authors： Kase CS,Maulsby GO,Mohr JP

更新日期：1980-06-01 00:00:00

abstract：:Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable ...

journal_title：Neurology

authors： Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

更新日期：1994-04-01 00:00:00

abstract：:Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...

journal_title：Neurology

authors： Carlen PL,Wilkinson DA,Wortzman G,Holgate R,Cordingley J,Lee MA,Huszar L,Moddel G,Singh R,Kiraly L,Rankin JG

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：:A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...

journal_title：Neurology

authors： Skipper L,Shen H,Chua E,Bonnard C,Kolatkar P,Tan LC,Jamora RD,Puvan K,Puong KY,Zhao Y,Pavanni R,Wong MC,Yuen Y,Farrer M,Liu JJ,Tan EK

更新日期：2005-10-25 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...

journal_title：Neurology

authors： Lochmüller H,Behin A,Caraco Y,Lau H,Mirabella M,Tournev I,Tarnopolsky M,Pogoryelova O,Woods C,Lai A,Shah J,Koutsoukos T,Skrinar A,Mansbach H,Kakkis E,Mozaffar T

更新日期：2019-04-30 00:00:00

abstract：OBJECTIVE:Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS:Data were from a population-based cohort st...

journal_title：Neurology

authors： Cramer C,Haan MN,Galea S,Langa KM,Kalbfleisch JD

更新日期：2008-07-29 00:00:00

abstract：:Four prolonged episodes of partial complex status epilepticus were observed in a teenaged girl. During each there was an "ictal" phase, in which her mental state frequently fluctuated between mildly clouded consciousness and almost total unresponsiveness; once, she was also blind during this phase of impaired consciou...

journal_title：Neurology

authors： Engel J Jr,Ludwig BI,Fetell M

更新日期：1978-09-01 00:00:00

abstract：:The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is lo...

journal_title：Neurology

authors： Rosengren LE,Karlsson JE,Sjögren M,Blennow K,Wallin A

更新日期：1999-03-23 00:00:00

abstract：:The ability to deliver enzymatically active human hexosaminidase A across the blood-brain barrier and into brain cells of the normal rat was examined. Following osmotic blood-brain barrier modification in the rat, intraarterially administered human hexosaminidase A and B were shown to cross the barrier and enter brain...

journal_title：Neurology

authors： Neuwelt EA,Barranger JA,Pagel MA,Quirk JM,Brady RO,Frenkel EP

更新日期：1984-08-01 00:00:00

abstract：:Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...

journal_title：Neurology

authors： Friedman JH,Ambler M

更新日期：1992-09-01 00:00:00

abstract：:To test possible biochemical mechanisms by which L-tryptophan may reverse mental side effects of levodopa therapy in parkinsonism we administered levodopa, 250 mg per kilogram intraperitoneally, alone and with L-tryptophan, 500 mg per kilogram intraperitoneally, to rats pretreated with the peripheral dopa decarboxylas...

journal_title：Neurology

authors： Fahn S,Snider S,Prasad AL,Lane E,Makadon H

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures. METHODS:This was a multicenter,...

journal_title：Neurology

authors： French JA,Krauss GL,Biton V,Squillacote D,Yang H,Laurenza A,Kumar D,Rogawski MA

更新日期：2012-08-07 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The f...

journal_title：Neurology

authors： Kemler MA,van de Vusse AC,van den Berg-Loonen EM,Barendse GA,van Kleef M,Weber WE

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...

journal_title：Neurology

authors： Valcour V,Shikuma C,Shiramizu B,Watters M,Poff P,Selnes O,Holck P,Grove J,Sacktor N

更新日期：2004-09-14 00:00:00

abstract：OBJECTIVE:To ascertain the prevalence and determinants of neuropathy in patients with Parkinson disease (PD), in particular, the roles of vitamin B12 and levodopa exposure. METHODS:We performed a cross-sectional study of 37 patients with PD and 37 age- and gender-matched controls, using a sensitive and validated neuro...

journal_title：Neurology

authors： Rajabally YA,Martey J

更新日期：2011-11-29 00:00:00

abstract：OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...

journal_title：Neurology

authors： Josephs KA,Duffy JR,Strand EA,Machulda MM,Senjem ML,Lowe VJ,Jack CR Jr,Whitwell JL

更新日期：2013-07-23 00:00:00

abstract：OBJECTIVE:To determine whether the incidence and clinical features of pediatric multiple sclerosis (MS) and other forms of pediatric acquired demyelinating syndromes (ADS) vary by race/ethnicity in a population-based cohort. METHODS:We used a combination of electronic database searches followed by complete medical rec...

journal_title：Neurology

authors： Langer-Gould A,Zhang JL,Chung J,Yeung Y,Waubant E,Yao J

更新日期：2011-09-20 00:00:00

abstract：OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

journal_title：Neurology

authors： Geranmayeh F,Leech R,Wise RJS

更新日期：2016-04-05 00:00:00

abstract：:Neurofibromatosis 2 (NF2), a dominantly inherited disorder, typically manifests as bilateral vestibular schwannomas and predisposes to other nervous system tumors. In this study, we present a large pedigree with a benign course of NF2 (mild Gardner type) characterized by slowly growing vestibular schwannomas but few o...

journal_title：Neurology

authors： Sainio M,Strachan T,Blomstedt G,Salonen O,Setälä K,Palotie A,Palo J,Pyykkö I,Peltonen L,Jääskeläinen J

更新日期：1995-07-01 00:00:00

abstract：:A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...

journal_title：Neurology

authors： Torch WC,Hirano A,Solomon S

更新日期：1977-12-01 00:00:00

abstract：:We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures...

journal_title：Neurology

authors： Lin YY,Su MS,Yiu CH,Shih YH,Yen DJ,Kwan SY,Wu ZA,Chan SH

更新日期：1997-08-01 00:00:00

abstract：:Surgery is a safe and effective treatment for patients with temporal lobe epilepsy (TLE) who do not respond adequately to anticonvulsant medication and in whom the seizure generator can be identified and safely removed. Proton MR spectroscopic imaging (MRSI) can image and quantify neuronal damage in patients with TLE ...

journal_title：Neurology

authors： Cendes F,Andermann F,Dubeau F,Matthews PM,Arnold DL

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVES:Assuming the involvement of homocysteine in a generalized small-vessel disease, we investigated the association of homocysteine levels with progression of white matter lesions, lacunar infarcts, and kidney disease. METHODS:Within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) St...

journal_title：Neurology

authors： Kloppenborg RP,Geerlings MI,Visseren FL,Mali WP,Vermeulen M,van der Graaf Y,Nederkoorn PJ,SMART Study Group.

更新日期：2014-03-04 00:00:00

abstract：OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...

journal_title：Neurology

authors： Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

更新日期：2010-03-16 00:00:00

abstract：:The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...

journal_title：Neurology

authors： Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

更新日期：2006-04-25 00:00:00

abstract：:To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...

journal_title：Neurology

authors： Lisak RP,Kuchmy D,Armati-Gulson PJ,Brown MJ,Sumner AJ

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of the single nucleotide polymorphism rs1080985 in the cytochrome P450 2D6 (CYP2D6) gene on the efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD). METHODS:This was a multicenter, prospective cohort study of 127 white patients with AD according to the Nat...

journal_title：Neurology

authors： Pilotto A,Franceschi M,D'Onofrio G,Bizzarro A,Mangialasche F,Cascavilla L,Paris F,Matera MG,Pilotto A,Daniele A,Mecocci P,Masullo C,Dallapiccola B,Seripa D

更新日期：2009-09-08 00:00:00