Norming plans for the NIH Toolbox.

Abstract:

OBJECTIVE:The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. METHODS:A large sample will be obtained from the US population for the purpose of calculating normative values. The sample will be stratified by age (ages 3-85 years), sex, and language preference (English or Spanish) and have a total sample size of at least 4,205. The sample will include a minimum of 25-100 individuals in each targeted demographic and language subgroup. RESULTS:Norming methods will include poststratification adjustment calculated using iterative proportional fitting, also known as raking, so that the weighted sample will have the same distribution on key demographic variables as the US population described in the 2010 Census. CONCLUSIONS:As with any set of norms, users should be mindful of the reference population and make conclusions consistent with the limitations of normative sampling, since it is not a probability-based sample. However, the NIH Toolbox norming study has been designed to minimize bias and maximize representativeness and precision of estimates. The availability of a "toolbox" of normed measures will be an important foundation for addressing critical research questions in neurologic and behavioral health.

journal_name

Neurology

journal_title

Neurology

authors

Beaumont JL,Havlik R,Cook KF,Hays RD,Wallner-Allen K,Korper SP,Lai JS,Nord C,Zill N,Choi S,Yost KJ,Ustsinovich V,Brouwers P,Hoffman HJ,Gershon R

doi

10.1212/WNL.0b013e3182872e70

subject

Has Abstract

pub_date

2013-03-12 00:00:00

pages

S87-92

issue

11 Suppl 3

eissn

0028-3878

issn

1526-632X

pii

80/11_Supplement_3/S87

journal_volume

80

pub_type

杂志文章
  • Multiple cerebral hemorrhages in HTLV-I-associated myelopathy.

    abstract::We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.2.412

    authors: Smith D,Lucas S,Jacewicz M

    更新日期:1993-02-01 00:00:00

  • Multifocal brain MRI artifacts secondary to embolic metal fragments.

    abstract::We report a patient with unusual MRI abnormalities that had the physical characteristics of ferromagnetic artifact. We believe that the MRI artifacts were due to microscopic embolic metal fragments, most likely from a mechanical heart valve prosthesis. Potential sources of metal emboli should be considered in patients...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.5.1451

    authors: Wingerchuk DM,Krecke KN,Fulgham JR

    更新日期:1997-11-01 00:00:00

  • Occurrence of sleep disorders in the families of narcoleptic patients.

    abstract::First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups....

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000229930.68094.48

    authors: Ohayon MM,Okun ML

    更新日期:2006-08-22 00:00:00

  • Short-term outcomes of skull fracture: a population-based study of survival and neurologic complications.

    abstract::All Olmsted County, Minnesota, residents who experienced brain injury from 1935 through 1979 were identified and their medical records reviewed for survival and neurologic outcome. Minimum inclusion criteria included loss of consciousness or post-traumatic amnesia or neurologic evidence of brain injury or skull fractu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.1.96

    authors: Wiederholt WC,Melton LJ 3rd,Annegers JF,Grabow JD,Laws ER Jr,Ilstrup DM

    更新日期:1989-01-01 00:00:00

  • Brain size, head size, and intelligence quotient in monozygotic twins.

    abstract::Many studies of monozygotic (MZ) twins have revealed evidence of genetic influences on intellectual functions and their derangement in certain neurologic and psychiatric diseases afflicting the forebrain. Relatively little is known about genetic influences on the size and shape of the human forebrain and its gross mor...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.50.5.1246

    authors: Tramo MJ,Loftus WC,Stukel TA,Green RL,Weaver JB,Gazzaniga MS

    更新日期:1998-05-01 00:00:00

  • Saccadic duration and intrasaccadic fatigue in myasthenic and nonmyasthenic ocular palsies.

    abstract::We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.11.2065

    authors: Barton JJ,Jama A,Sharpe JA

    更新日期:1995-11-01 00:00:00

  • Residual function in motor cortex contralateral to amputated hand.

    abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.4.984

    authors: Röricht S,Meyer BU

    更新日期:2000-02-22 00:00:00

  • Assessment of motor function after stereotactic pallidotomy.

    abstract::Despite a paucity of controlled data, stereotactic pallidotomy is increasingly used for the treatment of advanced Parkinson's disease (PD). To study the efficacy of the procedure on the cardinal PD features of rigidity, tremor, bradykinesia, and postural instability, we blindly rated randomized videos of 34 patients r...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.1.266

    authors: Ondo WG,Jankovic J,Lai EC,Sankhla C,Khan M,Ben-Arie L,Schwartz K,Grossman RG,Krauss JK

    更新日期:1998-01-01 00:00:00

  • Auditory and tactile processing in a postmeningitic deaf-blind patient with a cochlear implant.

    abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000234141.72891.13

    authors: Osaki Y,Takasawa M,Doi K,Nishimura H,Iwaki T,Imaizumi M,Oku N,Hatazawa J,Kubo T

    更新日期:2006-09-12 00:00:00

  • Patterns of postictal cerebral blood flow in temporal lobe epilepsy: qualitative and quantitative analysis.

    abstract::We used single-photon emission computed tomography (SPECT) to study postictal cerebral blood flow (CBF) in 51 patients with temporal lobe epilepsy. There were 78 seizures studied, 77 by early postictal injection of Tc-99m HMPAO (delay from seizure onset = 4.3 +/- 4.5 min) and one by ictal injection. Increased focal te...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.7.1096

    authors: Rowe CC,Berkovic SF,Austin MC,McKay WJ,Bladin PF

    更新日期:1991-07-01 00:00:00

  • The impact of neuropathic pain on health-related quality of life: review and implications.

    abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1212/01.wnl.0000259085.61898.9e

    authors: Jensen MP,Chodroff MJ,Dworkin RH

    更新日期:2007-04-10 00:00:00

  • Nonhemorrhagic infarction of the thalamus: behavioral, anatomic, and physiologic correlates.

    abstract::We studied five patients with nonhemorrhagic thalamic infarction with neuropsychological tests, CT, and somatosensory evoked responses (SERs). The three patients with left thalamic lesions had abnormalities of language, memory, visuospatial processing, intellect, and personality-changes compatible with dementia. The t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.1.14

    authors: Graff-Radford NR,Eslinger PJ,Damasio AR,Yamada T

    更新日期:1984-01-01 00:00:00

  • Predictive value of sensory and cognitive evoked potentials for awakening from coma.

    abstract:OBJECTIVES:To determine the prognostic role of late auditory (N100) and cognitive evoked potentials (MMN) for awakening in a cohort of comatose patients categorized by etiology. METHODS:The authors prospectively studied a series of 346 comatose patients. Coma was caused by stroke (n = 125), trauma (n = 96), anoxia (n ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000134670.10384.e2

    authors: Fischer C,Luauté J,Adeleine P,Morlet D

    更新日期:2004-08-24 00:00:00

  • Etiology of aseptic meningitis and encephalitis in an adult population.

    abstract:OBJECTIVE:To investigate the etiology of aseptic meningitis and encephalitis in an adult population using modern microbiologic methods. METHODS:Consecutive patients (ages > or =16) with aseptic meningitis or encephalitis treated in Turku University Hospital, Finland, during 1999 to 2003 were included in the study. Mic...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000191407.81333.00

    authors: Kupila L,Vuorinen T,Vainionpää R,Hukkanen V,Marttila RJ,Kotilainen P

    更新日期:2006-01-10 00:00:00

  • Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.

    abstract:OBJECTIVE:To describe a kindred with a dominantly inherited neurologic disorder manifested either as uncomplicated spastic paraplegia or ataxia, spastic paraplegia, and mental retardation. METHODS:Neurologic examinations and molecular genetic analysis (exclusion of known SCA and HSP genes and loci; and trinucleotide r...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.3.411

    authors: Hedera P,Rainier S,Zhao XP,Schalling M,Lindblad K,Yuan QP,Ikeuchi T,Trobe J,Wald JJ,Eldevik OP,Kluin K,Fink JK

    更新日期:2002-02-12 00:00:00

  • Clinical spectrum of episodic ataxia type 2.

    abstract::The authors searched for mutations in CACNA1A in patients with episodic ataxia and describe the clinical spectrum in genetically defined patients. Eighteen families and nine sporadic cases of episodic ataxia were evaluated for mutations in CACNA1A. The families were first genotyped to check for linkage to the chromoso...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000101675.61074.50

    authors: Jen J,Kim GW,Baloh RW

    更新日期:2004-01-13 00:00:00

  • Atypical neuronal ceroid-lipofuscinosis.

    abstract::We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.7.710

    authors: Greenwood RS,Nelson JS

    更新日期:1978-07-01 00:00:00

  • Abnormal ventilation during exercise in McArdle's syndrome: modulation by substrate availability.

    abstract::We evaluated ventilation during cycle exercise in four men lacking myophosphorylase. In submaximal exercise of similar relative intensity, ventilation was higher relative to oxygen uptake in McArdle patients than in normal men. The exercise ventilatory response returned to normal after glucose infusion, by fasting to ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.5.716

    authors: Haller RG,Lewis SF

    更新日期:1986-05-01 00:00:00

  • Comparison of single-dose meperidine, butorphanol, and dihydroergotamine in the treatment of vascular headache.

    abstract::We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol. Post-treatment pain scores were lowest in the DHE group (p less than 0.01). Eight of 21 patients receiving DHE had greater than 90% reduction in pain compared with three of 19 patients recei...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.39.4.590

    authors: Belgrade MJ,Ling LJ,Schleevogt MB,Ettinger MG,Ruiz E

    更新日期:1989-04-01 00:00:00

  • Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine.

    abstract:OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.wnl.0000123260.61631.c4

    authors: Silberstein S,Tepper S,Brandes J,Diamond M,Goldstein J,Winner P,Venkatraman S,Vrijens F,Malbecq W,Lines C,Visser WH,Reines S,Yuen E

    更新日期:2004-05-11 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824528b2

    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis.

    abstract::We performed serial baseline and gadolinium (Gd)-DTPA-enhanced MRI in 4 patients with definite multiple sclerosis. Studies were performed every month for a total of 4 scans. We obtained short TR/short TE sequences at 10 and 60 minutes after Gd-DTPA injection. All patients had multiple hyperintense lesions seen on base...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.4.591

    authors: Bastianello S,Pozzilli C,Bernardi S,Bozzao L,Fantozzi LM,Buttinelli C,Fieschi C

    更新日期:1990-04-01 00:00:00

  • Blink reflex excitability cycle in hemifacial spasm.

    abstract::We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.8.1061

    authors: Valls-Sole J,Tolosa ES

    更新日期:1989-08-01 00:00:00

  • The quicksilver prize: Mercury vapor poisoning aboard HMS Triumph and HMS Phipps.

    abstract::In 1810, two British ships, HMS Triumph and HMS Phipps, salvaged a large load of elemental mercury from a wrecked Spanish vessel near Cadiz, Spain. The bladders containing the mercury soon ruptured. The element spread about the ships in liquid and vapor forms. The sailors presented with neurologic compromises: tremor,...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/01.wnl.0000118789.33171.47

    authors: Doherty MJ

    更新日期:2004-03-23 00:00:00

  • The role of muscle biopsy in investigating isolated muscle pain.

    abstract:OBJECTIVE:To evaluate the muscle biopsy findings from 240 patients who had isolated muscle pain. METHODS:Histopathology, immunohistochemistry for dystrophin, dystrophin-related proteins, major histocompatibility complex type I, and biochemical analysis of glycolytic and mitochondrial respiratory chain enzymes were per...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000252252.29532.cc

    authors: Filosto M,Tonin P,Vattemi G,Bertolasi L,Simonati A,Rizzuto N,Tomelleri G

    更新日期:2007-01-16 00:00:00

  • Hepatic ketogenesis and muscle carnitine deficiency.

    abstract::The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.6.780

    authors: DiDonato S,Cornelio F,Storchi G,Rimoldi M

    更新日期:1979-06-01 00:00:00

  • CNS neutrophilic vasculitis in neuro-Sweet disease.

    abstract::In the Clinical/Scientific Note “CNS neutrophilic vasculitis in neuro-Sweet disease” by R. Charlson et al. (Neurology® 2015;85:829–830), there is an error in the discussion and the references. The last name of the first author of reference 2 should be Hisanaga, not Hisanga as originally published. The authors regret t...

    journal_title:Neurology

    pub_type: 已发布勘误

    doi:10.1212/WNL.0000000000002139

    authors:

    更新日期:2015-11-17 00:00:00

  • Tissue inhibitor metalloproteinase-1 and clinical outcomes after acute ischemic stroke.

    abstract:OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008389

    authors: Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

    更新日期:2019-10-29 00:00:00

  • Acoustic tumors: atypical features and recent diagnostic tests.

    abstract::About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.2.211

    authors: Hart RG,Gardner DP,Howieson J

    更新日期:1983-02-01 00:00:00

  • Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child

    abstract:OBJECTIVE:To evaluate published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy. METHODS:A multidisciplinary panel systematically reviewed relevant literature from 1966 to July 2008. RESULTS:For localized/segmental spasticity, botulinum toxin type A is establ...

    journal_title:Neurology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1212/WNL.0b013e3181cbcd2f

    authors: Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.,Delgado MR,Hirtz D,Aisen M,Ashwal S,Fehlings DL,McLaughlin J,Morrison LA,Shrader MW,Tilton A,Vargus-Adams

    更新日期:2010-01-26 00:00:00