Mild cognitive impairment, amnestic type: an epidemiologic study.


OBJECTIVE:To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample. METHODS:Retroactive application of MCI criteria to data collected during a prospective epidemiologic study was performed. The subjects were drawn from voter registration lists, composing a cohort of 1,248 individuals with mean age of 74.6 (5.3) years, who were nondemented at entry and who were assessed biennially over 10 years of follow-up. The Petersen amnestic MCI criteria were operationalized as 1) impaired memory: Word List Delayed Recall score of <1 SD below mean; 2) normal mental status: Mini-Mental State Examination score of 25+; 3) normal daily functioning: no instrumental impairments; 4) memory complaint: subjective response to standardized question; 5) not demented: Clinical Dementia Rating Scale score of <1. RESULTS:At the five assessments, amnestic MCI criteria were met by 2.9 to 4.0% of the cohort. Of 40 persons with MCI at the first assessment, 11 (27%) developed dementia over the next 10 years. Over each 2-year interval, MCI persons showed increased risk of dementing (odds ratio = 3.9, 95% CI = 2.1 to 7.2); 11.1 to 16.7% progressed to Alzheimer disease and 0 to 5.0% progressed to other dementias. Over the same intervals, 11.1 to 21.2% of those with MCI remained MCI; of 33.3 to 55.6% who no longer had MCI, half had reverted to normal. CONCLUSIONS:In this community-based sample, 3 to 4% of nondemented persons met MCI operational criteria; despite increased risk of progressing to dementia, a substantial proportion also remained stable or reverted to normal during follow-up. Amnestic MCI as currently defined is a high-risk but unstable and heterogeneous group.






Ganguli M,Dodge HH,Shen C,DeKosky ST




Has Abstract


2004-07-13 00:00:00














  • Cabergoline in Parkinson's disease: long-term follow-up.

    abstract::We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 2...


    pub_type: 杂志文章


    authors: Lera G,Vaamonde J,Rodriguez M,Obeso JA

    更新日期:1993-12-01 00:00:00

  • The child neurology clinical workforce in 2015: Report of the AAP/CNS Joint Taskforce.

    abstract:OBJECTIVES:More than a decade has passed since the last major workforce survey of child neurologists in the United States; thus, a reassessment of the child neurology workforce is needed, along with an inaugural assessment of a new related field, neurodevelopmental disabilities. METHODS:The American Academy of Pediatr...


    pub_type: 杂志文章


    authors: Kang PB,Bale JF Jr,Mintz M,Joshi SM,Gilbert DL,Radabaugh C,Ruch-Ross H,Section on Neurology Executive Committee of the American Academy of Pediatrics, and the Board of Directors of the Child Neurology Society.

    更新日期:2016-09-27 00:00:00

  • APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old.

    abstract:BACKGROUND:Many studies have examined the role of APOE genotype in the development of dementia, specifically Alzheimer disease (AD). The APOE epsilon4 allele (APOE4) is a risk factor for both clinical and neuropathologic AD whereas the APOE epsilon2 allele (APOE2) seems to be protective. This would predict, even with a...


    pub_type: 杂志文章


    authors: Berlau DJ,Corrada MM,Head E,Kawas CH

    更新日期:2009-03-03 00:00:00

  • Progression after chronic manganese exposure.

    abstract::We report a longitudinal follow-up study on six patients with chronic manganese-induced parkinsonism following cessation of manganese exposure. Compared with the 1987 study, their parkinsonian symptoms showed a slow progression, particularly in gait disturbances such as freezing during turning and walking backward wit...


    pub_type: 杂志文章


    authors: Huang CC,Lu CS,Chu NS,Hochberg F,Lilienfeld D,Olanow W,Calne DB

    更新日期:1993-08-01 00:00:00

  • Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.

    abstract::An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...


    pub_type: 杂志文章


    authors: Lavi E,Montone KT,Rorke LB,Kliman HJ

    更新日期:1991-09-01 00:00:00

  • Change in body mass index and risk of incident Alzheimer disease.

    abstract:OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...


    pub_type: 杂志文章


    authors: Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

    更新日期:2005-09-27 00:00:00

  • Insights into the natural history of spontaneous intracranial hypotension from infusion testing.

    abstract:OBJECTIVE:To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms, in a retrospective case-controlled study. METHODS:We included consecutive patients investigated for SIH at our department from January 2012 to...


    pub_type: 杂志文章


    authors: Häni L,Fung C,Jesse CM,Ulrich CT,Miesbach T,Cipriani DR,Dobrocky T,Z'Graggen WJ,Raabe A,Piechowiak EI,Beck J

    更新日期:2020-07-21 00:00:00

  • Treatment of Bell palsy with prednisone: a prospective, randomized study.

    abstract::Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; mot...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf SM,Wagner JH,Davidson S,Forsythe A

    更新日期:1978-02-01 00:00:00

  • Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma.

    abstract:OBJECTIVE:A subset of meningiomas recur after surgery and radiation therapy, but no medical therapy for recurrent meningioma has proven effective. METHODS:Pasireotide LAR is a long-acting somatostatin analog that may inhibit meningioma growth. This was a phase II trial in patients with histologically confirmed recurre...


    pub_type: 杂志文章


    authors: Norden AD,Ligon KL,Hammond SN,Muzikansky A,Reardon DA,Kaley TJ,Batchelor TT,Plotkin SR,Raizer JJ,Wong ET,Drappatz J,Lesser GJ,Haidar S,Beroukhim R,Lee EQ,Doherty L,Lafrankie D,Gaffey SC,Gerard M,Smith KH,McCluskey

    更新日期:2015-01-20 00:00:00

  • Effect of rebleeding on the course and incidence of vasospasm after subarachnoid hemorrhage.

    abstract:OBJECTIVE:Rebleeding of an aneurysm is a leading cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Whereas numerous studies have demonstrated the risk factors associated with rebleeding, few data on complications of rebleeding, including its effect on the development of delayed cerebral ischemia (DC...


    pub_type: 杂志文章


    authors: Lord AS,Fernandez L,Schmidt JM,Mayer SA,Claassen J,Lee K,Connolly ES,Badjatia N

    更新日期:2012-01-03 00:00:00

  • Identification of new and common mutations in the EPM2A gene in Lafora disease.

    abstract::Lafora disease is a teenage onset progressive myoclonus epilepsy caused by mutations in the EPM2A gene. In this report, we describe new mutations within EPM2A, review the known mutations to date to identify the most common, and describe three simple tests for prenatal and carrier screening. ...


    pub_type: 杂志文章


    authors: Minassian BA,Ianzano L,Delgado-Escueta AV,Scherer SW

    更新日期:2000-01-25 00:00:00

  • Dystonia in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.

    abstract::Adult-onset dystonia-parkinsonism is a syndrome in search of a pathology. We therefore reviewed the literature on dystonic manifestations in autopsy-proven cases of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and idiopathic Parkinson's disease (PD). Only 6 of 140 autopsy reports of MSA remarke...


    pub_type: 杂志文章,评审


    authors: Rivest J,Quinn N,Marsden CD

    更新日期:1990-10-01 00:00:00

  • PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women.

    abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...


    pub_type: 杂志文章


    authors: Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

    更新日期:2020-11-18 00:00:00

  • Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

    abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...


    pub_type: 杂志文章


    authors: Masliah E,Alford M,Adame A,Rockenstein E,Galasko D,Salmon D,Hansen LA,Thal LJ

    更新日期:2003-07-22 00:00:00

  • Whole-brain MRI phenotyping in dysplasia-related frontal lobe epilepsy.

    abstract:OBJECTIVE:To perform whole-brain morphometry in patients with frontal lobe epilepsy and evaluate the utility of group-level patterns for individualized diagnosis and prognosis. METHODS:We compared MRI-based cortical thickness and folding complexity between 2 frontal lobe epilepsy cohorts with histologically verified f...


    pub_type: 杂志文章


    authors: Hong SJ,Bernhardt BC,Schrader DS,Bernasconi N,Bernasconi A

    更新日期:2016-02-16 00:00:00

  • Sign language aphasia due to left occipital lesion in a deaf signer.

    abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...


    pub_type: 杂志文章


    authors: Saito K,Otsuki M,Ueno S

    更新日期:2007-10-02 00:00:00

  • Unsteady gaze fixation enhances the severity of MS intention tremor.

    abstract:BACKGROUND:Patients with arm intention tremor due to multiple sclerosis (MS) often manifest eye movement deficits, illustrating the role of infratentorial brain in both ocular and manual movement control. Our previous study showed that both the amplitude of intention tremor and eye fixational movements were greatly enh...


    pub_type: 杂志文章


    authors: Feys P,Helsen W,Nuttin B,Lavrysen A,Ketelaer P,Swinnen S,Liu X

    更新日期:2008-01-08 00:00:00

  • MRI and neuropsychological differences in early- and late-life-onset geriatric depression.

    abstract::We sought to determine whether geriatric patients with late-life-onset major depression have more subcortical hyperintensities on MRI and greater cognitive impairment than age-matched geriatric patients with early-life-onset major depression, suggesting that subcortical disease may be etiologic in late-life depression...


    pub_type: 杂志文章


    authors: Salloway S,Malloy P,Kohn R,Gillard E,Duffy J,Rogg J,Tung G,Richardson E,Thomas C,Westlake R

    更新日期:1996-06-01 00:00:00

  • Concerns of surrogate decision makers for patients with acute brain injury: A US population survey.

    abstract:OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...


    pub_type: 杂志文章


    authors: Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

    更新日期:2020-05-12 00:00:00

  • Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurolo...


    pub_type: 杂志文章,评审


    authors: Giza CC,Kutcher JS,Ashwal S,Barth J,Getchius TS,Gioia GA,Gronseth GS,Guskiewicz K,Mandel S,Manley G,McKeag DB,Thurman DJ,Zafonte R

    更新日期:2013-06-11 00:00:00

  • Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis.

    abstract:OBJECTIVE:To perform a meta-analysis of 4 core CSF biomarkers (β-amyloid [Aβ]42, Aβ40, total tau [t-tau], and phosphorylated tau [p-tau]) to assess which of these are most altered in sporadic cerebral amyloid angiopathy (CAA). METHODS:We systematically searched PubMed for eligible studies reporting data on CSF biomark...


    pub_type: 杂志文章,meta分析,评审


    authors: Charidimou A,Friedrich JO,Greenberg SM,Viswanathan A

    更新日期:2018-02-27 00:00:00

  • Qualitative study of burnout, career satisfaction, and well-being among US neurologists in 2016.

    abstract:OBJECTIVE:To understand the experience and identify drivers and mitigating factors of burnout and well-being among US neurologists. METHODS:Inductive data analysis was applied to free text comments (n = 676) from the 2016 American Academy of Neurology survey of burnout, career satisfaction, and well-being. RESULTS:Re...


    pub_type: 杂志文章


    authors: Miyasaki JM,Rheaume C,Gulya L,Ellenstein A,Schwarz HB,Vidic TR,Shanafelt TD,Cascino TL,Keran CM,Busis NA

    更新日期:2017-10-17 00:00:00

  • Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes.

    abstract::The long-term evolution of Hu antibody (Hu-Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu-Ab titers in 35 patients with PNS with a median follow-up of 32 months (range 6 to 108 months). No correlation was observed between Hu-Ab titers and neurologi...


    pub_type: 杂志文章,评审


    authors: Lladó A,Mannucci P,Carpentier AF,Paris S,Blanco Y,Saiz A,Delattre JY,Graus F

    更新日期:2004-11-23 00:00:00

  • Combined azathioprine and prednisone in chronic inflammatory-demyelinating polyneuropathy.

    abstract::Twenty-seven patients with static or worsening chronic inflammatory-demyelinating polyradiculoneuropathy were randomly assigned to alternate day decremental prednisone therapy alone or with azathioprine (2 mg/kg) for 9 months. No statistically significant alterations were demonstrated between these treatment schedules...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dyck PJ,O'Brien P,Swanson C,Low P,Daube J

    更新日期:1985-08-01 00:00:00

  • Cognition in multiple sclerosis: State of the field and priorities for the future.

    abstract::Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...


    pub_type: 杂志文章,评审


    authors: Sumowski JF,Benedict R,Enzinger C,Filippi M,Geurts JJ,Hamalainen P,Hulst H,Inglese M,Leavitt VM,Rocca MA,Rosti-Otajarvi EM,Rao S

    更新日期:2018-02-06 00:00:00

  • Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site.

    abstract:OBJECTIVE:To characterize the molecular basis of a novel fast-channel congenital myasthenic syndrome. METHODS:We used the candidate gene approach to identify the pathogenic mutation in the acetylcholine receptor (AChR) ε subunit, genetically engineered the mutant AChR into HEK cells, and evaluated the level of express...


    pub_type: 杂志文章


    authors: Shen XM,Brengman JM,Edvardson S,Sine SM,Engel AG

    更新日期:2012-07-31 00:00:00

  • Acute naming deficits following dominant temporal lobectomy: prediction by age at 1st risk for seizures.

    abstract::Age at 1st risk for seizures may predict anomia following dominant anterior temporal lobectomy. We assessed confrontation naming before and 2 to 3 weeks after surgery in 45 right-handed patients grouped by side of focus and presence or absence of early (less than or equal to 5 years) risk factors. After left lobectomy...


    pub_type: 杂志文章


    authors: Stafiniak P,Saykin AJ,Sperling MR,Kester DB,Robinson LJ,O'Connor MJ,Gur RC

    更新日期:1990-10-01 00:00:00

  • The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

    abstract:OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...


    pub_type: 杂志文章


    authors: Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TA

    更新日期:2001-11-27 00:00:00

  • Hepatic ketogenesis and muscle carnitine deficiency.

    abstract::The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...


    pub_type: 杂志文章


    authors: DiDonato S,Cornelio F,Storchi G,Rimoldi M

    更新日期:1979-06-01 00:00:00

  • CNS vasculitis in a patient with MS on daclizumab monotherapy.

    abstract:OBJECTIVE:To report the development of CNS vasculitis in a patient with multiple sclerosis (MS) treated with daclizumab. METHODS:This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. RESULTS:After completing a phase II daclizumab monotherapy study with an optimal response as evidenced ...


    pub_type: 杂志文章


    authors: Ohayon J,Oh U,Richert N,Martin J,Vortmeyer A,McFarland H,Bielekova B

    更新日期:2013-01-29 00:00:00