Acetylcholine receptor antibody synthesis by thymic lymphocytes: correlation with thymic histology.


:Antiacetylcholine receptor antibody (anti-AChR) was spontaneously synthesized by cultured thymic tissue from 19 of 35 patients with myasthenia gravis. Two other thymus cultures produced antibody after stimulation by pokeweed mitogen. Antibody production correlated with histologic evidence of thymitis, long duration of symptoms, or high serum anti-AChR values. None of seven thymomas synthesized antibody in culture, but evidence suggested that there had been in vivo synthesis or trapping of anti-AChR. Clinical improvement after thymectomy, during the short period of study, did not correlate with synthesis rates of anti-AChR production by the removed thymus. The rates of anti-AChR production in culture were too low to suggest that the thymus is the major source of this antibody. Although we did not find a clear relationship between anti-AChR antibody and clinical state within 3 months of thymectomy, in a study of 25 nonimmunosuppressed, nonthymoma patients followed for 1 to 4 years, we found a significant correlation (p less than 0.05, Spearman Rank correlation) between fall in anti-AChR antibody and clinical improvement after thymectomy (unpublished observations).






Scadding GK,Vincent A,Newsom-Davis J,Henry K




Has Abstract


1981-08-01 00:00:00












  • Neurologic complications after gastric restriction surgery for morbid obesity.

    abstract::We report the occurrence of neurologic complications in 23 patients who underwent gastric restriction surgery for the treatment of morbid obesity. Complications occurred 3 to 20 months after surgery. All the patients had had protracted vomiting for the first 3 months after the operation. The following syndromes were f...


    pub_type: 杂志文章


    authors: Abarbanel JM,Berginer VM,Osimani A,Solomon H,Charuzi I

    更新日期:1987-02-01 00:00:00

  • Giant cell (temporal) arteritis: a treatable cause of multi-infarct dementia.

    abstract::Dementia occurs infrequently in patients with giant cell (temporal) arteritis (GCA). Three elderly women with biopsy-proven GCA showed abrupt cognitive decline during periods of clinically active GCA, 1 to 6 months after diagnostic temporal artery biopsy, during periods of corticosteroid taper. One patient had additio...


    pub_type: 杂志文章


    authors: Caselli RJ

    更新日期:1990-05-01 00:00:00

  • Preclinical detection of Parkinson's disease: biochemical approaches.

    abstract::Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...


    pub_type: 杂志文章,评审


    authors: Parker WD Jr

    更新日期:1991-05-01 00:00:00

  • Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study.

    abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...


    pub_type: 杂志文章


    authors: Carlesimo GA,Cherubini A,Caltagirone C,Spalletta G

    更新日期:2010-01-19 00:00:00

  • Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene.

    abstract::We report a family with an X-linked recessive disorder characterized by muscle cramps and myalgia. Nine affected male family members had high resting serum levels of creatine kinase, and well-developed musculature with calf hypertrophy but no evidence of muscular weakness. Symptoms began in childhood and did not progr...


    pub_type: 杂志文章


    authors: Gospe SM Jr,Lazaro RP,Lava NS,Grootscholten PM,Scott MO,Fischbeck KH

    更新日期:1989-10-01 00:00:00

  • Amino-terminal deletion of 53% of dystrophin results in an intermediate Duchenne-Becker muscular dystrophy phenotype.

    abstract::We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...


    pub_type: 杂志文章


    authors: Takeshima Y,Nishio H,Narita N,Wada H,Ishikawa Y,Ishikawa Y,Minami R,Nakamura H,Matsuo M

    更新日期:1994-09-01 00:00:00

  • Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

    abstract::Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the path...


    pub_type: 杂志文章


    authors: Sprenger T,Willoch F,Miederer M,Schindler F,Valet M,Berthele A,Spilker ME,Förderreuther S,Straube A,Stangier I,Wester HJ,Tölle TR

    更新日期:2006-04-11 00:00:00

  • Acute myopathy associated with gasoline sniffing.

    abstract::Acute myopathy and myoglobinuria with markedly elevated creatine kinase (CK) activity developed in an 18-year-old boy on two occasions after gasoline sniffing. No signs of CNS involvement were seen, and the symptoms receded in a few days. The amount of lead in blood and urine exceeded the reference value for subjects ...


    pub_type: 杂志文章


    authors: Kovanen J,Somer H,Schroeder P

    更新日期:1983-05-01 00:00:00

  • Disconnection as a mechanism for social cognition impairment in multiple sclerosis.

    abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...


    pub_type: 杂志文章


    authors: Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

    更新日期:2017-07-04 00:00:00

  • Reduced occipital GABA in Parkinson disease with visual hallucinations.

    abstract:OBJECTIVE:To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. METHODS:We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex vi...


    pub_type: 杂志文章


    authors: Firbank MJ,Parikh J,Murphy N,Killen A,Allan CL,Collerton D,Blamire AM,Taylor JP

    更新日期:2018-08-14 00:00:00

  • Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a.

    abstract:BACKGROUND:Findings from a small clinical study suggested that statins may counteract the therapeutic effects of interferon beta (IFNbeta) in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:We conducted a post hoc analysis of data from the Safety and Efficacy of Natalizumab in Combination With IFN...


    pub_type: 临床试验,杂志文章


    authors: Rudick RA,Pace A,Rani MR,Hyde R,Panzara M,Appachi S,Shrock J,Maurer SL,Calabresi PA,Confavreux C,Galetta SL,Lublin FD,Radue EW,Ransohoff RM

    更新日期:2009-06-09 00:00:00

  • Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.

    abstract:OBJECTIVE:The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study. METHODS:A novel ex vivo assay was developed to identify pesticides that can inhibi...


    pub_type: 杂志文章


    authors: Fitzmaurice AG,Rhodes SL,Cockburn M,Ritz B,Bronstein JM

    更新日期:2014-02-04 00:00:00

  • Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis.

    abstract::Immunomodulating agents have beneficial effects in the treatment of multiple sclerosis (MS), decreasing the frequency of relapses, the progression of disability, and MRI measures of disease activity. Despite the efficacy of these agents, many patients continue to show progression of disability, breakthrough relapses, ...


    pub_type: 杂志文章,评审


    authors: Jeffery DR

    更新日期:2004-12-28 00:00:00

  • A clinical staging classification for type C Niemann-Pick disease.

    abstract::Analysis of the temporal sequence of neurologic events, neurophysiologic abnormalities, and longevity in 36 Niemann-Pick type C patients revealed two clinical subgroups with five stages of severity within each group. Patients with a preschool onset (group I; n = 18) had a higher mortality than did patients with a scho...


    pub_type: 杂志文章


    authors: Higgins JJ,Patterson MC,Dambrosia JM,Pikus AT,Pentchev PG,Sato S,Brady RO,Barton NW

    更新日期:1992-12-01 00:00:00

  • Imitation synkinesia and sensory control of movement.

    abstract::Immitation synkinesia is usually associated with thalamic or parietal lesions. Analysis of three cases shows that the lesions may affect the posterior columns of the spinal cord or even the peripheral nervous system. In our cases, two facts stand out, a large measure of integrity of motor activity and predominant dist...


    pub_type: 杂志文章


    authors: Cambier J,Dehen H

    更新日期:1977-07-01 00:00:00

  • Cognitive outcome after aneurysm rupture: relationship to aneurysm site and perioperative complications.

    abstract::We evaluated cognitive outcome in a group of 37 patients who had undergone surgery for rupture and repair of a single intracranial aneurysm at least 6 months previously. We compared outcome--assessed by tests of intelligence, attention, executive functions sensitive to frontal lobe lesions, memory, neglect, and mood, ...


    pub_type: 杂志文章


    authors: Tidswell P,Dias PS,Sagar HJ,Mayes AR,Battersby RD

    更新日期:1995-05-01 00:00:00

  • Mechanisms of action of anticonvulsant agents.

    abstract::Systematic screening of many compounds in animal models led to identification of the established antiepileptic drugs (AEDs). By contrast, the newer AEDs were specifically designed to enhance an inhibitory process or to inhibit a specific excitatory pathway. However, it was later discovered that some of the designed dr...


    pub_type: 杂志文章,评审


    authors: Moshé SL

    更新日期:2000-01-01 00:00:00

  • Late-onset depressive symptoms increase the risk of dementia in small vessel disease.

    abstract:OBJECTIVE:We prospectively investigated the role of depressive symptoms (DS) on all-cause dementia in a population with small vessel disease (SVD), considering onset age of DS and cognitive performance. METHODS:The RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) is a prospect...


    pub_type: 杂志文章


    authors: van Uden IW,van der Holst HM,van Leijsen EM,Tuladhar AM,van Norden AG,de Laat KF,Claassen JA,van Dijk EJ,Kessels RP,Richard E,Tendolkar I,de Leeuw FE

    更新日期:2016-09-13 00:00:00

  • Adrenergic innervation in autonomic failure.

    abstract::In 10 patients with chronic autonomic failure, the sympathetic perivascular nerve plexuses from quadriceps muscle biopsies were studied by catecholamine fluorescence and electronmicroscopy. There was almost complete absence of catecholamine fluorescence and fewer than normal numbers of small granular (noradrenergic) v...


    pub_type: 杂志文章


    authors: Bannister R,Crowe R,Eames R,Burnstock G

    更新日期:1981-12-01 00:00:00

  • The cognitive profile of posterior cortical atrophy.

    abstract:BACKGROUND:Posterior cortical atrophy (PCA) is a progressive dementia characterized by prominent disorders of higher visual processing, affecting both dorsal and ventral streams to cause Balint's syndrome, alexia, and visual agnosia. OBJECTIVE:To define the cognitive profile of PCA and compare to the typical, primary ...


    pub_type: 杂志文章


    authors: McMonagle P,Deering F,Berliner Y,Kertesz A

    更新日期:2006-02-14 00:00:00

  • Headache types and panic disorder: directionality and specificity.

    abstract:OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...


    pub_type: 杂志文章


    authors: Breslau N,Schultz LR,Stewart WF,Lipton R,Welch KM

    更新日期:2001-02-13 00:00:00

  • Met-enkephalin immunoreactivity in the basal ganglia in Parkinson's disease and striatonigral degeneration.

    abstract::This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...


    pub_type: 杂志文章


    authors: Goto S,Hirano A,Matsumoto S

    更新日期:1990-07-01 00:00:00

  • Lumbosacral plexus neuritis.

    abstract::We studied four patients with neurologic disorders of the lumbosacral plexus. Except for location of symptoms, the disorder confirmed to criteria established for the clinical diagnosis of brachial plexus neuritis. Acute onset of pain in one or both legs was followed by weakness, loss of stretch reflexes, and sometimes...


    pub_type: 杂志文章


    authors: Sander JE,Sharp FR

    更新日期:1981-04-01 00:00:00

  • Why do frontal lobe symptoms predominate in vascular dementia with lacunes?

    abstract::We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...


    pub_type: 杂志文章


    authors: Ishii N,Nishihara Y,Imamura T

    更新日期:1986-03-01 00:00:00

  • Transient drug-induced abolition of BAEPs in coma.

    abstract::Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but ...


    pub_type: 杂志文章


    authors: García-Larrea L,Artru F,Bertrand O,Pernier J,Mauguière F

    更新日期:1988-09-01 00:00:00

  • Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study.

    abstract:OBJECTIVE:To investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between brain amyloid load and cognitive performance and vascular risk factors. METHODS:A sub...


    pub_type: 杂志文章


    authors: Kemppainen N,Johansson J,Teuho J,Parkkola R,Joutsa J,Ngandu T,Solomon A,Stephen R,Liu Y,Hänninen T,Paajanen T,Laatikainen T,Soininen H,Jula A,Rokka J,Rissanen E,Vahlberg T,Peltoniemi J,Kivipelto M,Rinne JO

    更新日期:2018-01-16 00:00:00

  • Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study.

    abstract:OBJECTIVE:To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS). METHODS:A cohort of 112 patients (73 women) with clinically definitive MS or a clinically isolated s...


    pub_type: 杂志文章


    authors: Eisele P,Griebe M,Szabo K,Wolf ME,Alonso A,Engelhardt B,Hennerici MG,Gass A

    更新日期:2015-02-24 00:00:00

  • Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis.

    abstract::Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable ...


    pub_type: 杂志文章


    authors: Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

    更新日期:1994-04-01 00:00:00

  • Occurrence of sleep disorders in the families of narcoleptic patients.

    abstract::First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups....


    pub_type: 杂志文章


    authors: Ohayon MM,Okun ML

    更新日期:2006-08-22 00:00:00

  • Optic neuritis: a population-based study in Olmsted County, Minnesota.

    abstract::We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regres...


    pub_type: 杂志文章


    authors: Rodriguez M,Siva A,Cross SA,O'Brien PC,Kurland LT

    更新日期:1995-02-01 00:00:00