Abstract:
:A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintained for more than 1 year. An open trial of imipramine in another 16 patients showed an initial reduction in seizure frequency in 10 patients (63 percent), and this decrease persisted for more than 1 year in 4 patients (25 percent). The effect of imipramine on the EEG did not always correlate with the clinical response. Serum content of imipramine in the patients who showed a long-term response was 40 to 120 ng per milliliter, on a total daily dose of 0.7 to 3.5 mg per kilogram. These results suggest that imipramine is a valuable addition to the treatment of seizures.
journal_name
Neurologyjournal_title
Neurologyauthors
Fromm GH,Wessel HB,Glass JD,Alvin JD,Van Horn Gdoi
10.1212/wnl.28.9.953subject
Has Abstractpub_date
1978-09-01 00:00:00pages
953-7issue
9 Pt 1eissn
0028-3878issn
1526-632Xjournal_volume
28pub_type
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