Burnout, career satisfaction, and well-being among US neurology residents and fellows in 2016.

abstract：OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...

journal_title：Neurology

authors： Steward KA,Gerstenecker A,Triebel KL,Kennedy R,Novack TA,Dreer LE,Marson DC

更新日期：2016-09-06 00:00:00

abstract：:Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...

journal_title：Neurology

authors： Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

更新日期：1982-12-01 00:00:00

abstract：:We present four patients with typical neonatal onset non-ketotic hyperglycinemia (NKH) who developed hydrocephalus requiring shunting in early infancy. Brain imaging revealed acute hydrocephalus, a megacisterna magna or posterior fossa cyst, pronounced atrophy of the white matter, and an extremely thin corpus callosum...

journal_title：Neurology

authors： Van Hove JL,Kishnani PS,Demaerel P,Kahler SG,Miller C,Jaeken J,Rutledge SL

更新日期：2000-02-08 00:00:00

abstract：BACKGROUND:Transcranial contrast Doppler studies have shown an increased prevalence of right-to-left shunts in patients with migraine with aura compared with controls. The anatomy and size of these right-to-left shunts have never been directly assessed. METHODS:In a cross-sectional case-control study, the authors perf...

journal_title：Neurology

authors： Schwerzmann M,Nedeltchev K,Lagger F,Mattle HP,Windecker S,Meier B,Seiler C

更新日期：2005-11-08 00:00:00

abstract：:Cabergoline, a new ergoline derivative, is a D2-specific dopaminergic agonist that is more potent and longer-acting than other agonist agents. We conducted a randomized, double-blind study of increasing doses of cabergoline taken once a day. Twenty-five patients with Parkinson's disease taking stable doses of levodopa...

journal_title：Neurology

authors： Hutton JT,Morris JL,Brewer MA

更新日期：1993-03-01 00:00:00

abstract：:We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...

journal_title：Neurology

authors： Jeerakathil TJ,Kirk A

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The Vietnam Head Injury Study (VHIS) is a prospective, longitudinal follow-up of 1,221 Vietnam War veterans with mostly penetrating head injuries (PHIs). The high prevalence (45%-53%) of posttraumatic epilepsy (PTE) in this unique cohort makes it valuable for study. METHODS:A standardized multidisciplinary ...

journal_title：Neurology

authors： Raymont V,Salazar AM,Lipsky R,Goldman D,Tasick G,Grafman J

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Galantamine is a reversible, competitive cholinesterase inhibitor that also allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action provided the rationale for a therapeutic trial of galantamine in AD. METHODS:A 6-month, multicenter, double-blind trial was undertaken in 636 pat...

journal_title：Neurology

authors： Raskind MA,Peskind ER,Wessel T,Yuan W

更新日期：2000-06-27 00:00:00

abstract：OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...

journal_title：Neurology

authors： Lipton RB,Tepper SJ,Reuter U,Silberstein S,Stewart WF,Nilsen J,Leonardi DK,Desai P,Cheng S,Mikol DD,Lenz R

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To examine the ability of diffusion-weighted MRI (DWI) to detect ongoing cerebral ischemia in patients with vascular dementia (VaD). BACKGROUND:VaD due to small-vessel disease results from the cumulative impact of recurrent cerebral ischemia. Cerebral ischemia may produce clinical manifestations, producing t...

journal_title：Neurology

authors： Choi SH,Na DL,Chung CS,Lee KH,Na DG,Adair JC

更新日期：2000-01-11 00:00:00

abstract：OBJECTIVE:To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. METHODS:We previously reported an upgoing thumb sign as a subtle clinical finding in patients with tran...

journal_title：Neurology

authors： Hachinski V,Alsubaie R,Azarpazhooh MR

更新日期：2017-07-25 00:00:00

abstract：:Because hereditary hyperekplexia results from a defect in the glycine receptor, we studied in five patients several spinal inhibitory pathways that are thought to use either glycine or gamma-aminobutyric acid as a neurotransmitter. Three patients had a mutation in the alpha1 subunit of the glycine receptor, whereas tw...

journal_title：Neurology

authors： Floeter MK,Andermann F,Andermann E,Nigro M,Hallett M

更新日期：1996-03-01 00:00:00

abstract：:Cerebral cavernous malformations (CCM) are CNS vascular anomalies associated with seizures, headaches, and hemorrhagic strokes. The CCM1 gene was screened in 35 sporadic cases with either single or multiple CCM. It was found that 29% of the individuals with multiple CCM have a CCM1 mutation, whereas cases with only on...

journal_title：Neurology

authors： Verlaan DJ,Laurent SB,Sure U,Bertalanffy H,Andermann E,Andermann F,Rouleau GA,Siegel AM

更新日期：2004-04-13 00:00:00

abstract：:Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...

journal_title：Neurology

authors： Silverstein FS,Johnston MV,Hutchinson RJ,Edwards NL

更新日期：1985-06-01 00:00:00

abstract：:In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...

journal_title：Neurology

authors： Sanders DB,Massey EW,Buckley EG

更新日期：1986-04-01 00:00:00

abstract：:Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shed...

journal_title：Neurology

authors： Burger D,Dayer JM

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...

journal_title：Neurology

authors： Fonseca AC,Marto JP,Pimenta D,Guimarães T,Alves PN,Inácio N,Viana-Baptista M,Pinho E Melo T,Pinto FJ,Ferro JM,Almeida AG

更新日期：2020-01-07 00:00:00

abstract：OBJECTIVE:To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings. METHODS:Clinicians and scientists with expertise in the use of MRI i...

journal_title：Neurology

authors： Oh J,Ontaneda D,Azevedo C,Klawiter EC,Absinta M,Arnold DL,Bakshi R,Calabresi PA,Crainiceanu C,Dewey B,Freeman L,Gauthier S,Henry R,Inglese M,Kolind S,Li DKB,Mainero C,Menon RS,Nair G,Narayanan S,Nelson F,Pelleti

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...

journal_title：Neurology

authors： Kuwabara S,Misawa S,Kanai K,Suzuki Y,Kikkawa Y,Sawai S,Hattori T,Nishimura M,Nakaseko C

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Previous studies link posterior border-zone cerebral infarcts between the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) to hemodynamic causes, not embolism. OBJECTIVE:To study the cause of these infarcts. METHODS:We studied 21 patients (unilateral = 18, bilateral = 3) with acute, sym...

journal_title：Neurology

authors： Belden JR,Caplan LR,Pessin MS,Kwan E

更新日期：1999-10-12 00:00:00

abstract：OBJECTIVE:To determine the incidence of spinocerebellar ataxia (SCA) types 1, 2, 3, 6, and 7 and Friedreich's ataxia (FA) among a large panel of ataxia families. BACKGROUND:The ataxias are a clinically and genetically heterogeneous group of neurodegenerative diseases that variably affect the cerebellum, brainstem, and...

journal_title：Neurology

authors： Moseley ML,Benzow KA,Schut LJ,Bird TD,Gomez CM,Barkhaus PE,Blindauer KA,Labuda M,Pandolfo M,Koob MD,Ranum LP

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. METHODS:We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who u...

journal_title：Neurology

authors： Echouffo-Tcheugui JB,Conner SC,Himali JJ,Maillard P,DeCarli CS,Beiser AS,Vasan RS,Seshadri S

更新日期：2018-11-20 00:00:00

abstract：:We describe a familial disorder consisting of sleep apnea, anosmia, colorblindness, partial complex seizures, and cognitive dysfunction. The phenotypic expression of the syndrome suggests an autosomal dominant inheritance with incomplete penetrance. ...

journal_title：Neurology

authors： Manon-Espaillat R,Gothe B,Adams N,Newman C,Ruff R

更新日期：1988-02-01 00:00:00

abstract：:The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...

journal_title：Neurology

authors： Seripa D,Matera MG,D'Andrea RP,Gravina C,Masullo C,Daniele A,Bizzarro A,Rinaldi M,Antuono P,Wekstein DR,Dal Forno G,Fazio VM

更新日期：2004-05-11 00:00:00

abstract：:Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...

journal_title：Neurology

authors： Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

更新日期：1987-12-01 00:00:00

abstract：:The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...

journal_title：Neurology

authors： DiDonato S,Cornelio F,Storchi G,Rimoldi M

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVE:The diagnosis of psychogenic nonepileptic seizures (PNES) can be challenging. In the absence of a gold standard to verify the reliability of the diagnosis by EEG-video, we sought to assess the interrater reliability of the diagnosis using EEG-video recordings. METHODS:Patient samples consisted of 22 unselect...

journal_title：Neurology

authors： Benbadis SR,LaFrance WC Jr,Papandonatos GD,Korabathina K,Lin K,Kraemer HC,NES Treatment Workshop.

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Adiponectin is a protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic properties. In this study, we investigated the relationship between adiponectin levels and ischemic stroke subtype. METHODS:Using clinical, imaging, and laboratory data, 231 consecutive patient...

journal_title：Neurology

authors： Bang OY,Saver JL,Ovbiagele B,Choi YJ,Yoon SR,Lee KH

更新日期：2007-05-29 00:00:00

abstract：OBJECTIVES:To investigate longitudinally the profile of cognitive impairment in nondemented patients with ALS. METHODS:Twenty nondemented patients with ALS and 18 controls were interviewed at two time points separated by a 6-month interval. The extensive battery was designed to accommodate the range of physical disabi...

journal_title：Neurology

authors： Abrahams S,Leigh PN,Goldstein LH

更新日期：2005-04-12 00:00:00

abstract：:A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation. Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mechanisms may be responsible; however, shar...

journal_title：Neurology

authors： Jette N,Veregin T,Guberman A

更新日期：2002-07-23 00:00:00