What is the risk of developing parkinsonism following neuroleptic use?

Abstract:

:Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self-reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Survey participants. Although more research is needed, these data suggest that 126 Medicare beneficiaries would need to be treated with neuroleptic medications to cause one additional case of self-reported PD.

journal_name

Neurology

journal_title

Neurology

authors

Noyes K,Liu H,Holloway RG

doi

10.1212/01.wnl.0000203348.13337.89

subject

Has Abstract

pub_date

2006-03-28 00:00:00

pages

941-3

issue

6

eissn

0028-3878

issn

1526-632X

pii

66/6/941

journal_volume

66

pub_type

杂志文章
  • Quantitation of herpes simplex virus type 1 DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis.

    abstract::We used a nested polymerase chain reaction assay to quantitate the number of viral copies in cells of CSF of eight patients with herpes simplex virus encephalitis (HSVE). The viral load was monitored in serial CSF samples during the course of disease and correlated to clinical symptoms, radiologic manifestations, effi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.5.1341

    authors: Wildemann B,Ehrhart K,Storch-Hagenlocher B,Meyding-Lamadé U,Steinvorth S,Hacke W,Haas J

    更新日期:1997-05-01 00:00:00

  • The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage.

    abstract::Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients. We discuss seven patients with amyloid angiopathy presenting without major lobar hemorrhage. The patients' presentations fell into two groups: recurrent transient neurologic symptoms and rapidly progressive dementia. The...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.10.2073

    authors: Greenberg SM,Vonsattel JP,Stakes JW,Gruber M,Finklestein SP

    更新日期:1993-10-01 00:00:00

  • Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test.

    abstract::To determine if there is abnormal phenylalanine and biopterin metabolism in patients with dopa-responsive dystonia (DRD), we measured plasma levels of phenylalanine, tyrosine, biopterin, and neopterin at baseline, and 1, 2, 4, and 6 hours after an oral phenylalanine load (100 mg/kg). Seven adults with DRD, two severel...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.5.1290

    authors: Hyland K,Fryburg JS,Wilson WG,Bebin EM,Arnold LA,Gunasekera RS,Jacobson RD,Rost-Ruffner E,Trugman JM

    更新日期:1997-05-01 00:00:00

  • Effects of cannabis on cognitive function in patients with multiple sclerosis.

    abstract:BACKGROUND:While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318212ab0c

    authors: Honarmand K,Tierney MC,O'Connor P,Feinstein A

    更新日期:2011-03-29 00:00:00

  • Selective deficit of praxis imagery in ideomotor apraxia.

    abstract::We studied imagery for learned, skilled movements (praxis imagery) in a patient with severe ideomotor apraxia and intact language abilities. This patient, who made predominantly spatial and movement errors when performing transitive movements demonstrating the use of tools (transitive gestures), was also impaired in h...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.2.474

    authors: Ochipa C,Rapcsak SZ,Maher LM,Rothi LJ,Bowers D,Heilman KM

    更新日期:1997-08-01 00:00:00

  • Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.

    abstract::Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:

    authors: LeWitt PA,Nelson MV,Berchou RC,Galloway MP,Kesaree N,Kareti D,Schlick P

    更新日期:1989-11-01 00:00:00

  • Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis.

    abstract::Immunomodulating agents have beneficial effects in the treatment of multiple sclerosis (MS), decreasing the frequency of relapses, the progression of disability, and MRI measures of disease activity. Despite the efficacy of these agents, many patients continue to show progression of disability, breakthrough relapses, ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.63.12_suppl_6.s41

    authors: Jeffery DR

    更新日期:2004-12-28 00:00:00

  • Relation of EEG alpha background to parietal lobe function in Alzheimer's disease as measured by positron emission tomography and psychometry.

    abstract::Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.5.747

    authors: Sheridan PH,Sato S,Foster N,Bruno G,Cox C,Fedio P,Chase TN

    更新日期:1988-05-01 00:00:00

  • The biphasic pattern of age-specific malignant brain tumor mortality rates.

    abstract::Many aging-associated neurologic disorders, including primary malignant brain tumors (MBT), share a common biphasic age-specific mortality rate pattern: initially increasing exponentially with age, and then declining. A modeling study using MBT mortality was conducted to determine if the observed biphasic pattern of M...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.55.6.750

    authors: Riggs JE

    更新日期:2000-09-26 00:00:00

  • Orthostatic hypotension as a risk factor for symptomatic occlusive cerebrovascular disease.

    abstract::Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.1.30

    authors: Dobkin BH

    更新日期:1989-01-01 00:00:00

  • Acute, chronic, and recurrent varicella zoster virus neuropathy without zoster rash.

    abstract::The authors report three patients with acute, chronic, and recurrent neuropathy associated with varicella zoster virus (VZV) infection but without zoster rash. CSF of all three patients contained VZV immunoglobulin G antibody, but not herpes simplex virus. In two patients, serum/CSF ratios of VZV immunoglobulin G were...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.2.351

    authors: Fox RJ,Galetta SL,Mahalingam R,Wellish M,Forghani B,Gilden DH

    更新日期:2001-07-24 00:00:00

  • Mitochondrial encephalomyopathy with coenzyme Q10 deficiency.

    abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.5.1238

    authors: Sobreira C,Hirano M,Shanske S,Keller RK,Haller RG,Davidson E,Santorelli FM,Miranda AF,Bonilla E,Mojon DS,Barreira AA,King MP,DiMauro S

    更新日期:1997-05-01 00:00:00

  • Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial.

    abstract:BACKGROUND:Physicians are often asked to predict outcome after acute stroke. Very little information is available that can reliably predict the likelihood of severe disability or death. OBJECTIVE:To develop a practical method for predicting a poor outcome after acute ischemic stroke. METHODS:Data from the placebo arm...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.7.952

    authors: Frankel MR,Morgenstern LB,Kwiatkowski T,Lu M,Tilley BC,Broderick JP,Libman R,Levine SR,Brott T

    更新日期:2000-10-10 00:00:00

  • Disordered swallowing due to a syrinx: correction by shunting.

    abstract::Disturbed deglutition is common in diseases of the brainstem and lower cranial nerves, but little is known about the mechanisms involved. We studied a 49-year-old man with symptoms of syringomyelia and syringobulbia lasting 7 years. Esophageal motility studies showed inability to initiate swallowing, esophageal hypomo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.11.1497

    authors: Bleck TP,Shannon KM

    更新日期:1984-11-01 00:00:00

  • Preservation of branchimotor neurons of the nucleus ambiguus in multiple system atrophy.

    abstract::Cholinergic neurons in the nucleus ambiguus (NA) were counted in autopsy tissue obtained from five patients with multiple system atrophy (MSA), four patients with PD, and five controls. The number of neurons in the dorsal NA was not significantly different among the three groups. Neurons in the ventrolateral portion o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000042087.07133.87

    authors: Benarroch EE,Schmeichel AM,Parisi JE

    更新日期:2003-01-14 00:00:00

  • PCR-based strategy for the diagnosis of hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease type 1A.

    abstract::Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are inherited peripheral neuropathies. In most cases these disorders are caused by either the duplication (in CMT1A) or the deletion (in HNPP) of a 1.5-megabase DNA fragment on chromosome 17p11.2, which cont...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.3.760

    authors: Young P,Stögbauer F,Wiebusch H,Löfgren A,Timmerman V,Van Broeckhoven C,Ringelstein EB,Assmann G,Funke H

    更新日期:1998-03-01 00:00:00

  • Distribution of lacunes in cerebral amyloid angiopathy and hypertensive small vessel disease.

    abstract:OBJECTIVE:To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS:We defined ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004007

    authors: Pasi M,Boulouis G,Fotiadis P,Auriel E,Charidimou A,Haley K,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

    更新日期:2017-06-06 00:00:00

  • Spontaneous spinal epidural hematoma in the young.

    abstract::There have been few descriptions of spontaneous epidural hematoma of the spinal cord in children. Duration of symptoms in previous cases has varied from hours to days. We recently evaluated a 6-year-old girl with cord compression from an extradural clot, who complained of thoracic back pain for 3 months before becomin...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.1.120

    authors: Robertson WC Jr,Lee YE,Edmonson MB

    更新日期:1979-01-01 00:00:00

  • HIV neuropathy natural history cohort study: assessment measures and risk factors.

    abstract:BACKGROUND:Distal sensory polyneuropathy (DSP) is the most common neurologic complication of human immunodeficiency virus (HIV) infection. Risk factors for DSP have not been adequately defined in the era of highly active antiretroviral therapy. METHODS:The authors evaluated 101 subjects with advanced HIV infection ove...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1212/01.wnl.0000218303.48113.5d

    authors: Simpson DM,Kitch D,Evans SR,McArthur JC,Asmuth DM,Cohen B,Goodkin K,Gerschenson M,So Y,Marra CM,Diaz-Arrastia R,Shriver S,Millar L,Clifford DB,ACTG A5117 Study Group.

    更新日期:2006-06-13 00:00:00

  • The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.

    abstract::Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31820d9507

    authors: Soliven B,Miron V,Chun J

    更新日期:2011-02-22 00:00:00

  • Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease.

    abstract:OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000185

    authors: Zhu J,Wang Y,Li J,Deng J,Zhou H

    更新日期:2014-03-11 00:00:00

  • Motor abilities after frontal leukotomy.

    abstract::The effect of bilateral frontal leukotomy on motor function was evaluated by neurologic examination, tests of praxis, and appropriate neuropsychologic tests administered to five groups of subjects. Postleukotomy schizophrenic patients were subdivided into three degrees of recovery. Two nonleukotomized groups served as...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.12.1353

    authors: Benson DF,Stuss DT

    更新日期:1982-12-01 00:00:00

  • Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates.

    abstract:OBJECTIVE:To assess the effect of usage of three different versions of Creutzfeldt-Jakob disease (CJD) diagnostic criteria on estimates of CJD incidence. METHODS:A total of 428 patients referred for suspected sporadic CJD between 1991 and 1997 were classified according to different criteria to be compared after analys...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.5.1095

    authors: Brandel JP,Delasnerie-Lauprêtre N,Laplanche JL,Hauw JJ,Alpérovitch A

    更新日期:2000-03-14 00:00:00

  • A distinctive autosomal dominant vacuolar neuromyopathy linked to 19p13.

    abstract:OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.4.830

    authors: Servidei S,Capon F,Spinazzola A,Mirabella M,Semprini S,de Rosa G,Gennarelli M,Sangiuolo F,Ricci E,Mohrenweiser HW,Dallapiccola B,Tonali P,Novelli G

    更新日期:1999-09-11 00:00:00

  • Efficacy of subcutaneous sumatriptan in repeated episodes of migraine.

    abstract::This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires asse...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.43.7.1363

    authors: Cady RK,Dexter J,Sargent JD,Markley H,Osterhaus JT,Webster CJ

    更新日期:1993-07-01 00:00:00

  • CSF biomarkers predict a more malignant outcome in Alzheimer disease.

    abstract:OBJECTIVE:To investigate if patterns of CSF biomarkers (T-tau, P-tau, and Abeta42) can predict cognitive progression, outcome of cholinesterase inhibitor (ChEI) treatment, and mortality in Alzheimer disease (AD). METHODS:We included outpatients with AD (n = 151) from a prospective treatment study with ChEI. At baselin...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181dd4dd8

    authors: Wallin AK,Blennow K,Zetterberg H,Londos E,Minthon L,Hansson O

    更新日期:2010-05-11 00:00:00

  • Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor.

    abstract:OBJECTIVE:To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. METHODS:...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0000000000008561

    authors: Halpern CH,Santini V,Lipsman N,Lozano AM,Schwartz ML,Shah BB,Elias WJ,Cosgrove GR,Hayes MT,McDannold N,Aldrich C,Eisenberg HM,Gandhi D,Taira T,Gwinn R,Ro S,Witt J,Jung NY,Chang JW,Rosenberg J,Ghanouni P

    更新日期:2019-12-10 00:00:00

  • A prospective study on the incidence and prognosis of Guillain-Barré syndrome in Emilia-Romagna region, Italy (1992-1993). Emilia-Romagna Study Group on Clinical and Epidemiological Problems in Neurology.

    abstract::We performed a multicenter prospective study on the incidence and prognosis of Guillain-Barré syndrome (GBS) in the Emilia-Romagna region (3,909,512 inhabitants), Italy, over a 2-year period (1992-1993). The case finding method was based on a surveillance system including neurologic departments, all private and public...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1997-01-01 00:00:00

  • Leukoencephalopathy in childhood leukemia.

    abstract::A 14-year-old boy survived for 7 years after the initial diagnosis and treatment of acute lymphocytic leukemia. Neurologic deterioration occured repeatedly throughout his complicated clinical course but it was most severe and only partially reversible following orally administered pyrimethamine. The neuropathologic le...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.7.609

    authors: Devivo DC,Malas D,Nelson JS,Land VJ

    更新日期:1977-07-01 00:00:00

  • Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: a biochemical assessment.

    abstract::The urinary excretion of some important phenylethylamines, catecholamines, their metabolites, amphetamine, and methamphetamine were measured in parkinsonian patients on Sinemet (L-dopa plus carbidopa, a peripheral dopadecarboxylase inhibitor) and depressed patients after chronic (-) deprenyl treatment. Deprenyl was ef...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.5.503

    authors: Karoum F,Chuang LW,Eisler T,Calne DB,Liebowitz MR,Quitkin FM,Klein DF,Wyatt RJ

    更新日期:1982-05-01 00:00:00