Abstract:
OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility during an entire year. Our primary annual MS identification algorithm required 2 inpatient claims coded ICD-9 340 or 3 outpatient claims coded ICD-9 340 or 1 MS-indicated disease-modifying therapy claim. Age-adjusted annual prevalence estimates were extrapolated to the US population using US Census data. RESULTS:The 2012 MS prevalence was 149.2 per 100,000 individuals (95% confidence interval 147.6-150.9). Prevalence was consistent over 2008-2012. Female participants were 3.13 times more likely to have MS. The highest prevalence was in participants aged 45-49 years (303.5 per 100,000 individuals [295.6-311.5]). The East Census region recorded the highest prevalence (192.1 [188.2-196.0]); the West Census region recorded the lowest prevalence (110.7 [105.5-116.0]). The US annual 2012 MS extrapolated population was 403,630 (387,445-419,833). CONCLUSIONS:MS prevalence rates from a representative commercially insured database were higher than or consistent with prior US estimates. For further accuracy improvement of US prevalence estimates, results should be confirmed after validation of MS identification algorithms, and should be expanded to other US populations, including the government-insured and the uninsured.
journal_name
Neurologyjournal_title
Neurologyauthors
Dilokthornsakul P,Valuck RJ,Nair KV,Corboy JR,Allen RR,Campbell JDdoi
10.1212/WNL.0000000000002469subject
Has Abstractpub_date
2016-03-15 00:00:00pages
1014-21issue
11eissn
0028-3878issn
1526-632Xpii
WNL.0000000000002469journal_volume
86pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract::Electroencephalography has traditionally been considered a useful adjunct to the clinical evaluation of headache. We performed a literature review to determine whether evidence supports the routine use of the electroencephalogram (EEG) for patients with headache. After excluding case reports, case series in which subj...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.45.7.1263
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to clarify myocardial involvement and its clinical implications in subjects with spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease affecting both neuronal and nonneuronal tissues. METHODS:Two independent cardiologists evaluated ECGs from a total of 144 consecutive s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000434
更新日期:2014-05-20 00:00:00
abstract::We studied a 55-year-old woman with macrosquare wave jerks and macrosaccadic oscillations with a vertical component. The oscillations almost completely disappeared after administration of diazepam, clonazepam, thiamylal, or phenobarbital. A disorder of GABAergic tonic inhibitory system from the substantia nigra to sup...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.9.1230
更新日期:1986-09-01 00:00:00
abstract::Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000194227.16696.11
更新日期:2006-01-24 00:00:00
abstract:OBJECTIVE:To assess whether the association between reperfusion and improved clinical outcomes after stroke differs depending on the site of the arterial occlusive lesion (AOL). METHODS:We pooled data from Solitaire With the Intention for Thrombectomy (SWIFT), Solitaire FR Thrombectomy for Acute Revascularisation (STA...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000002399
更新日期:2016-02-23 00:00:00
abstract:BACKGROUND AND PURPOSE:Persistently elevated intracranial pressure (ICP) has been associated with poor clinical outcome after severe brain injury, such as neurotrauma, intracerebral hemorrhage, and subarachnoidal hemorrhage. Although ICP monitoring is increasingly being used in intensive care treatment of patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.393
更新日期:1996-08-01 00:00:00
abstract::A patient who abused multiple drugs developed a rapidly progressive mononeuropathy multiplex, which appeared to respond to corticosteroid therapy with partial resolution. Intravenous methamphetamine had been used almost exclusively from the fourth month prior to the onset of symptoms. Biopsy material revealed a necrot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.6.570
更新日期:1975-06-01 00:00:00
abstract::Parry-Romberg syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive facial hemiatrophy. In this study, 205 patients with PRS were surveyed using the Internet. Estimates of the frequency of limb involvement (19%), epilepsy (11%), and other clinical and etiologic features were obtained. There was...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.61.5.674
更新日期:2003-09-09 00:00:00
abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.550
更新日期:1981-05-01 00:00:00
abstract::The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.8.1334
更新日期:1987-08-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS:We defined ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004007
更新日期:2017-06-06 00:00:00
abstract::Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self-reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Surve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000203348.13337.89
更新日期:2006-03-28 00:00:00
abstract::To evaluate when it is possible to discontinue anticonvulsant treatment in children with cryptogenic partial epilepsy, the authors studied 89 epileptic children divided into two groups: Group A, 45 children whose therapy was discontinued after 1 year from the last seizure; and Group B, 44 children whose therapy was st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.9.1393
更新日期:2000-11-14 00:00:00
abstract:OBJECTIVE:To report the assessment of a patient exhibiting gustatory agnosia. METHODS:Preoperative and postoperative neuropsychological, neuroimaging, and chemosensory evaluations were performed in a 39-year-old woman undergoing surgical treatment for intractable epilepsy. RESULTS:Preoperative MRIs showed bilateral (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000149515.77718.35
更新日期:2005-01-25 00:00:00
abstract::Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.3.239
更新日期:1978-03-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors. METHODS:Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one E...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000237475.01655.9d
更新日期:2006-09-26 00:00:00
abstract::The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.908
更新日期:2001-09-11 00:00:00
abstract:OBJECTIVE:To estimate rates, predictors, and prognostic importance of recanalization in an unselected series of patients with stroke treated with IV thrombolysis. METHODS:We performed a CT angiography or transcranial Doppler (TCD) follow-up examination 24 hours after IV thrombolysis in 64 patients with documented occl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000250341.38014.d2
更新日期:2007-01-02 00:00:00
abstract::The association between migraine and cervical artery dissection (CAD) was explored in a hospital-based case-control study. Migraine was present in 49.1% (23/47) of patients with CAD and in 21% (11/52) of patients hospitalized for a cerebral ischemic event not related to a CAD (adjusted odds ratio = 3.6; 1.5 to 8.6, p ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.3.435
更新日期:2002-08-13 00:00:00
abstract::The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142258.29304.fe
更新日期:2004-10-26 00:00:00
abstract:OBJECTIVE:To determine the accuracy of the clinical history performed by epileptologists in the identification of seizures in patients with suspected temporal lobe epilepsy. METHODS:The clinical and EEG telemetry (EEGT) monitoring data of 88 patients with suspected refractory temporal lobe seizures referred for evalua...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000090566.40544.04
更新日期:2003-12-23 00:00:00
abstract:OBJECTIVE:To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS:Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS:Speech w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003635
更新日期:2017-02-21 00:00:00
abstract:OBJECTIVE:To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region. DESIGN:A family history questionnaire was used to obtain information on all first-degree relatives ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.155
更新日期:1996-07-01 00:00:00
abstract::We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000001004
更新日期:2014-11-18 00:00:00
abstract::Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.4.377
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To relate signs and symptoms to morphologic changes and presence of multiple mitochondrial DNA (mtDNA) deletions in a patient with autosomal dominant progressive external ophthalmoplegia (adPEO) and mitochondrial myopathy. BACKGROUND:An etiologic association between the somatic multiple mtDNA deletions in ad...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.1.79
更新日期:1999-07-13 00:00:00
abstract:OBJECTIVE:To determine the diagnostic accuracy and prognostic value of ¹⁸FDG-PET in a recent series of patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) and negative MRI. METHODS:Of 23 consecutive patients (12 male, 7-38 years old) wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820203a9
更新日期:2010-12-14 00:00:00
abstract::The syndrome of increased intracranial pressure without hydrocephalus or mass lesion and with normal CSF composition, previously referred to as pseudotumor cerebri, is a diagnosis of exclusion now termed idiopathic intracranial hypertension (IIH). Diagnostic criteria of this disorder have not been updated since the Mo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000029570.69134.1b
更新日期:2002-11-26 00:00:00
abstract:BACKGROUND:UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. OBJECTIVE:To investigate whether these Gulf War-related symptoms were associated with objective evidence of neuromuscular dysfunction. METHODS:Forty-nine Gulf War veterans with more than four neu...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000032755.27372.fc
更新日期:2002-11-26 00:00:00