Genesis of Alzheimer's disease.

abstract：OBJECTIVE:To describe risk and risk factors of epilepsy after hospitalization for brain infection in adults in Sweden. METHODS:This was a matched retrospective cohort study based on the comprehensive National Patient and Cause of Death Registers. All individuals age >18 without prior epilepsy who received inpatient ca...

journal_title：Neurology

authors： Zelano J,Westman G

更新日期：2020-12-15 00:00:00

abstract：:Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...

journal_title：Neurology

authors： Devinsky O,Asato M,Camfield P,Geller E,Kanner AM,Keller S,Kerr M,Kossoff EH,Lau H,Kothare S,Singh BK,Wirrell E

更新日期：2015-10-27 00:00:00

abstract：OBJECTIVE:The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la com...

journal_title：Neurology

authors： Lanska DJ,Lanska JR

更新日期：2013-02-26 00:00:00

abstract：OBJECTIVE:The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level ...

journal_title：Neurology

authors： Schulte LH,Allers A,May A

更新日期：2018-05-29 00:00:00

abstract：:The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...

journal_title：Neurology

authors： Bonafé L,Blau N,Burlina AP,Romstad A,Güttler F,Burlina AB

更新日期：2001-09-11 00:00:00

abstract：OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...

journal_title：Neurology

authors： Budhiraja R,Javaheri S,Pavlova MK,Epstein LJ,Omobomi O,Quan SF

更新日期：2020-04-28 00:00:00

abstract：OBJECTIVE:To study the presenting features and value of routine diagnostic procedures in patients with leptomeningeal metastases (LMM) related to the primary malignancy to improve diagnostic assessment. METHODS:The authors studied the presenting features and value of routine diagnostic procedures in relation to the hi...

journal_title：Neurology

authors： van Oostenbrugge RJ,Twijnstra A

更新日期：1999-07-22 00:00:00

abstract：BACKGROUND:The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS). OBJECTIVE:To determine the incidence, clinical fe...

journal_title：Neurology

authors： Banwell B,Kennedy J,Sadovnick D,Arnold DL,Magalhaes S,Wambera K,Connolly MB,Yager J,Mah JK,Shah N,Sebire G,Meaney B,Dilenge ME,Lortie A,Whiting S,Doja A,Levin S,MacDonald EA,Meek D,Wood E,Lowry N,Buckley D,Yim

更新日期：2009-01-20 00:00:00

abstract：OBJECTIVE:To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2. METHODS:VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients. Clinical and ...

journal_title：Neurology

authors： van Sonderen A,Schreurs MW,de Bruijn MA,Boukhrissi S,Nagtzaam MM,Hulsenboom ES,Enting RH,Thijs RD,Wirtz PW,Sillevis Smitt PA,Titulaer MJ

更新日期：2016-05-03 00:00:00

abstract：:Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...

journal_title：Neurology

authors： Majoor-Krakauer D,Ottman R,Johnson WG,Rowland LP

更新日期：1994-10-01 00:00:00

abstract：:Inhibitory antibody to von Willebrand factor (vWF)-cleaving protease (ADAMTS13) was detected in a patient with intravascular lymphomatosis. The increased serum level of the antibody paralleled an increase in the expression of uncleaved vWF, which might cause microvascular thrombosis and platelet consumption. Malignant...

journal_title：Neurology

authors： Kawahara M,Kanno M,Matsumoto M,Nakamura S,Fujimura Y,Ueno S

更新日期：2004-11-09 00:00:00

abstract：:Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...

journal_title：Neurology

authors： Wijdicks EFM

更新日期：2020-06-09 00:00:00

abstract：:Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clin...

journal_title：Neurology

authors： Klawans HL

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...

journal_title：Neurology

authors： Lee DY,Fletcher E,Martinez O,Ortega M,Zozulya N,Kim J,Tran J,Buonocore M,Carmichael O,DeCarli C

更新日期：2009-11-24 00:00:00

abstract：OBJECTIVE:To define the clinical and radiologic features of brainstem gliomas (BSGs) in children with neurofibromatosis type 1 (NF1). METHODS:We performed a retrospective cross-sectional study of 133 children with NF1 and concurrent BSGs cared for at 4 NF1 referral centers. BSG was determined using radiographic criter...

journal_title：Neurology

authors： Mahdi J,Shah AC,Sato A,Morris SM,McKinstry RC,Listernick R,Packer RJ,Fisher MJ,Gutmann DH

更新日期：2017-04-18 00:00:00

abstract：OBJECTIVE:The aim of the study was to perform a third cognitive assessment in our pediatric-onset multiple sclerosis (MS) patient cohort and determine predictors of the individual cognitive outcome. METHODS:After 4.7 ± 0.7 years from baseline evaluation, 48 of 63 patients in the original cohort were reassessed on an e...

journal_title：Neurology

authors： Amato MP,Goretti B,Ghezzi A,Hakiki B,Niccolai C,Lori S,Moiola L,Falautano M,Viterbo RG,Patti F,Cilia S,Pozzilli C,Bianchi V,Roscio M,Martinelli V,Comi G,Portaccio E,Trojano M,MS Study Group of the Italian Neurological

更新日期：2014-10-14 00:00:00

abstract：:We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...

journal_title：Neurology

authors： Jeerakathil TJ,Kirk A

更新日期：1994-04-01 00:00:00

abstract：:We observed a highly topographically specific and consistent pattern of degeneration in the auditory system of Alzheimer's disease (AD) patients. Senile plaques (SP) and neurofibrillary tangles (NFT) were distributed throughout the ventral nucleus of the medial geniculate body (MGB) and the central nucleus of the infe...

journal_title：Neurology

authors： Sinha UK,Hollen KM,Rodriguez R,Miller CA

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:The prognostic value of the biochemical changes seen with proton MR spectroscopy (1H MRS) in ischemic stroke was examined. Acute diffusion-weighted imaging (DWI) was used to identify regions of ischemia for 1H MRS voxel localization. METHODS:Nineteen patients had 36 1H MRS studies, 13 patients acutely (mean...

journal_title：Neurology

authors： Parsons MW,Li T,Barber PA,Yang Q,Darby DG,Desmond PM,Gerraty RP,Tress BM,Davis SM

更新日期：2000-08-22 00:00:00

abstract：OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...

journal_title：Neurology

authors： Lipton RB,Bigal ME,Diamond M,Freitag F,Reed ML,Stewart WF,AMPP Advisory Group.

更新日期：2007-01-30 00:00:00

abstract：:In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...

journal_title：Neurology

authors： Van den Berg LH,Franssen H,Wokke JH

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To investigate botulinum toxin (BTX) effects on central and peripheral motor excitability in writer's cramp. METHODS:Using transcranial magnetic stimulation over the motor cortex and brainstem and peripheral electrical stimulation, the authors investigated measures of motor cortical and peripheral motor exci...

journal_title：Neurology

authors： Boroojerdi B,Cohen LG,Hallett M

更新日期：2003-12-09 00:00:00

abstract：OBJECTIVE:To study the clinical and radiologic spectrum and genotype-phenotype correlation of 4H (hypomyelination, hypodontia, hypogonadotropic hypogonadism) leukodystrophy caused by mutations in POLR3A or POLR3B. METHODS:We performed a multinational cross-sectional observational study of the clinical, radiologic, and...

journal_title：Neurology

authors： Wolf NI,Vanderver A,van Spaendonk RM,Schiffmann R,Brais B,Bugiani M,Sistermans E,Catsman-Berrevoets C,Kros JM,Pinto PS,Pohl D,Tirupathi S,Strømme P,de Grauw T,Fribourg S,Demos M,Pizzino A,Naidu S,Guerrero K,van der

更新日期：2014-11-18 00:00:00

abstract：:In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high...

journal_title：Neurology

authors： Troiano RA,Jotkowitz A,Cook SD,Bansil S,Zito G

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...

journal_title：Neurology

authors： Freeman JA,Hobart JC,Thompson AJ

更新日期：2001-07-10 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is incre...

journal_title：Neurology

authors： Fujioka S,Algom AA,Murray ME,Strongosky A,Soto-Ortolaza AI,Rademakers R,Ross OA,Wszolek ZK,Dickson DW

更新日期：2013-05-28 00:00:00

abstract：OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...

journal_title：Neurology

authors： Huang W,Alexander GE,Chang L,Shetty HU,Krasuski JS,Rapoport SI,Schapiro MB

更新日期：2001-08-28 00:00:00

abstract：OBJECTIVE:To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging. METHODS:We studied a subset of the larger Successful Aging after Elective Surgery (SAGES) study cohort of older adults (≥70 years) without dementia undergoing elective s...

journal_title：Neurology

authors： Cavallari M,Dai W,Guttmann CRG,Meier DS,Ngo LH,Hshieh TT,Fong TG,Schmitt E,Press DZ,Travison TG,Marcantonio ER,Jones RN,Inouye SK,Alsop DC,SAGES Study Group.

更新日期：2017-09-05 00:00:00

abstract：:We examined longitudinal disability scores in 54 patients with Parkinson's disease followed for 6 years at UCLA. We sorted data into 3 groups based on age at onset of symptoms: group A, onset under 50 years; group B, 50 to 59 years; group C, 60 years or older. There were no significant differences between groups initi...

journal_title：Neurology

authors： Diamond SG,Markham CH,Hoehn MM,McDowell FH,Muenter MD

更新日期：1989-09-01 00:00:00

abstract：:The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse ev...

journal_title：Neurology

authors： Killestein J,Hoogervorst EL,Reif M,Kalkers NF,Van Loenen AC,Staats PG,Gorter RW,Uitdehaag BM,Polman CH

更新日期：2002-05-14 00:00:00