Abstract:
:An autoimmune reaction to the endplate acetylcholine receptor (AChR) is thought to be responsible for the muscular weakness of myasthenia gravis (MG). However, the significance of antithymic antibodies and the thymic AChR-like protein is still uncertain. We transferred immunoglobulins (Igs) from patients with MG to mice. Thymitis was observed in 12 of 14 mice, and miniature endplate potential amplitudes were reduced in 8. Control mice showed none of these abnormalities. Immunofluorescence examination failed to reveal the binding of human IgG, IgM, or IgA to the thymic tissue. Our findings support the hypothesis that antithymic antibodies may alter thymic histology.
journal_name
Neurologyjournal_title
Neurologyauthors
Dalkara T,Onur R,Ruacan SA,Topaktaş Sdoi
10.1212/wnl.33.10.1356subject
Has Abstractpub_date
1983-10-01 00:00:00pages
1356-9issue
10eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
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