Abstract:
BACKGROUND:Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study evaluated the safety, tolerability, and immunogenicity of AN1792 (human aggregated Abeta42) in patients with mild to moderate AD. METHODS:Twenty patients were enrolled into each of four dose groups and randomly assigned to receive IM AN1792 (50 or 225 microg) with QS-21 adjuvant (50 or 100 microg) or QS-21 only (control) in a 4:1 active:control ratio on day 0 and at weeks 4, 12, and 24. Patients could receive up to four additional injections of a polysorbate 80 modified formulation at weeks 36, 48, 60, and 72. Safety, tolerability, immunogenicity, and exploratory evidence of efficacy were evaluated. RESULTS:Treatment-related adverse events were reported in 19 (23.8%) patients, but no relationship was observed between AN1792 dose and incidence. One patient developed meningoencephalitis that was diagnosed after death (not directly related to study treatment) and 219 days after discontinuing from the study. Five deaths occurred during the study follow-up, but none was considered to be directly related to study treatment. During the period of the first four injections, 23.4% of AN1792-treated patients had a positive anti-AN1792 antibody titer (an anti-AN1792 antibody titer of > or =1:1,000). This increased to 58.8% after additional injections with the modified formulation. Disability Assessment for Dementia scores showed less decline among active compared with control patients at week 84 (p = 0.002). No treatment differences were observed in three other efficacy measures. CONCLUSIONS:AN1792 + QS-21 elicited a positive antibody response to Abeta42 in more than half of this elderly study population.
journal_name
Neurologyjournal_title
Neurologyauthors
Bayer AJ,Bullock R,Jones RW,Wilkinson D,Paterson KR,Jenkins L,Millais SB,Donoghue Sdoi
10.1212/01.WNL.0000148604.77591.67subject
Has Abstractpub_date
2005-01-11 00:00:00pages
94-101issue
1eissn
0028-3878issn
1526-632Xpii
64/1/94journal_volume
64pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006544
更新日期:2018-11-20 00:00:00
abstract:OBJECTIVE:To quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles. METHODS:MRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with DMD and 51 healthy controls using a prospective observational stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009244
更新日期:2020-04-14 00:00:00
abstract::Using a perceptual technique it is shown that patients with chronic external ophthalmoplegia have shortened vestibular responses. It is postulated that this is secondary to the retinal image slip experienced by these patients during head movements and a useful compensatory mechanism to suppress motion-induced sickness...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000067992.17185.60
更新日期:2003-06-24 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract:OBJECTIVE:To investigate clinical differences in warm and cold complex regional pain syndrome (CRPS) phenotypes. BACKGROUND:CRPS represents inhomogeneous chronic pain conditions; approximately 70% patients with CRPS have "warm" affected limbs and 30% have "cold" affected limbs. METHODS:We examined 50 patients with "c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000341930.35494.66
更新日期:2009-02-10 00:00:00
abstract:OBJECTIVES:To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS:This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-bl...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3181e1ce73
更新日期:2010-06-08 00:00:00
abstract::The scanning electronmicroscope was used to study the development of anencephaly in an experimental model. Anencephaly was produced consistently, using vitamin A as the teratogen. Embryos destined to become anencephalic displayed failure of opposing sides of the rostral neural tube to fuse. Subsequently, the neural fo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.9.992
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:Distal sensory polyneuropathy (DSP) is the most common neurologic complication of human immunodeficiency virus (HIV) infection. Risk factors for DSP have not been adequately defined in the era of highly active antiretroviral therapy. METHODS:The authors evaluated 101 subjects with advanced HIV infection ove...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1212/01.wnl.0000218303.48113.5d
更新日期:2006-06-13 00:00:00
abstract:OBJECTIVE:To assess the effects of levodopa on resting-state brain metabolism in PD. BACKGROUND:In previous studies the authors used [18F] fluorodeoxyglucose (FDG) and PET to quantify regional metabolic abnormalities in PD. They found that this disease is characterized reproducibly by a specific abnormal PD-related pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2083
更新日期:2001-12-11 00:00:00
abstract:OBJECTIVE:To assess the correlation of tissue parameters estimated by quantitative magnetic resonance (MR) techniques and motor handicap in patients with hypomyelination. METHODS:Twenty-eight patients with different causes of hypomyelination (12 males, 16 females; mean age 10 years) and 61 controls (33 males, 28 femal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003000
更新日期:2016-08-23 00:00:00
abstract::T, B, and "null" lymphocytes were determined in peripheral blood obtained from 24 control subjects and 15 multiple sclerosis patients. The total number of lymphocytes and T lymphocytes were reduced significantly in multiple sclerosis patients as compared with those of controls. Although the percentage of B lymphocytes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.10.997
更新日期:1976-10-01 00:00:00
abstract::Patients with frontal lobe dementia (FLD) include those who suffer from Pick's disease, corticobasal degeneration, FLD without specific histopathologic features, as well as the infrequent families with frontotemporal dementia and parkinsonism associated with chromosome 17. Currently there have been no systematic effor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.suppl_4.s41
更新日期:2001-06-01 00:00:00
abstract::Degenerative diseases of the CNS, such as stiff-person syndrome (SPS), progressive cerebellar ataxia, and Rasmussen encephalitis, have been characterized by the presence of autoantibodies. Recent findings in individuals with Batten disease and in animal models for the disorder indicate that this condition may be assoc...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000145836.72059.3b
更新日期:2004-12-14 00:00:00
abstract::We report 9 cases of aphasia following lesions in the region of the left frontal operculum. It is not possible to capture their variety of clinical manifestations with the simple labels of "Broca's area aphasia." or "Broca's area aphasia." Analysis of the breakdown of various components of speech and language in these...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.2.353
更新日期:1990-02-01 00:00:00
abstract::We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.2.412
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To examine subjective versus objective memory change after anterior temporal lobectomy (ATL). METHODS:A prospective, controlled study. Controls included 39 unoperated patients with intractable temporal lobe epilepsy (TLE) who were administered a series of cognitive and health-related quality of life measures...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1511
更新日期:1999-10-22 00:00:00
abstract::Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.2.266
更新日期:2001-01-23 00:00:00
abstract::The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (li...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000228221.44334.73
更新日期:2006-08-08 00:00:00
abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.95
更新日期:1992-01-01 00:00:00
abstract::We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.9.1648
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To assess the expression of heat shock proteins (HSP) in glioma cells in vitro and in vivo and to examine their role in resistance to apoptosis. BACKGROUND:HSP are expressed in response to various forms of stress. Constitutive HSP expression may confer resistance to cytotoxic stimuli in human cancers. METHO...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.6.1357
更新日期:2000-03-28 00:00:00
abstract:OBJECTIVE:To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands. METHODS:In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a8236e
更新日期:2013-10-08 00:00:00
abstract:OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.1.68
更新日期:2001-07-10 00:00:00
abstract:OBJECTIVE:To provide updated evidence-based recommendations for migraine prevention using pharmacologic treatment with or without cognitive behavioral therapy in the pediatric population. METHODS:The authors systematically reviewed literature from January 2003 to August 2017 and developed practice recommendations usin...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000008105
更新日期:2019-09-10 00:00:00
abstract::A woman with typical features of myoclonic epilepsy with ragged red fibers (MERRF) had a novel heteroplasmic mutation (G611A) in the mitochondrial DNA tRNA phenylalanine gene. The mutation was heteroplasmic (91%) in muscle but undetectable in accessible tissues from the patient and her maternal relatives. Single-fiber...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000127608.48406.f1
更新日期:2004-06-08 00:00:00
abstract::We studied the effect of CSF drainage on cerebral blood flow (CBF) in normal pressure hydrocephalus (NPH) and non-NPH dementia using the 133Xenon inhalation technique. Dementia patients had lower CBF than matched elderly normals. Flow values for NPH and non-NPH patients did not differ before or after CSF drainage. CBF...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.1.96
更新日期:1984-01-01 00:00:00
abstract::Zinc is essential for normal embryogenesis and may have particular importance for closure of the human neural tube. Compared to 258 controls, we found increased zinc content in umbilical cord serum in eight of nine newborn anencephalics (p less than 0.02) and three infants with spina bifida (p less than 0.001). Increa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.4.443
更新日期:1984-04-01 00:00:00
abstract::The effect of bilateral frontal leukotomy on motor function was evaluated by neurologic examination, tests of praxis, and appropriate neuropsychologic tests administered to five groups of subjects. Postleukotomy schizophrenic patients were subdivided into three degrees of recovery. Two nonleukotomized groups served as...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.12.1353
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:To identify the genetic and physiologic basis for recessive myasthenic congenital myopathy in 2 families, suggestive of a channelopathy involving the sodium channel gene, SCN4A. METHODS:A combination of whole exome sequencing and targeted mutation analysis, followed by voltage-clamp studies of mutant sodium ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007185
更新日期:2019-03-26 00:00:00
abstract::One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.6.613
更新日期:1978-06-01 00:00:00