Cognitive screening examinations for silent cerebral infarcts in sickle cell disease.


OBJECTIVE:In children with sickle cell disease (SCD), silent cerebral infarcts are the most frequent cause of neurologic injury. We determined the sensitivity and specificity of selective neurocognitive measures when separating children with silent cerebral infarcts and SCD from sibling controls. Additionally, we tested the validity of the same cognitive measures to identify patients with overt strokes. METHODS:We examined performance on a neuropsychologic battery containing measures of attention/executive, spatial, language, memory, and motor functioning for seven children with SCD and silent cerebral infarct, 21 children with SCD and overt stroke, and 17 normal siblings. Diagnosis of cerebral infarct was based on results of MRI. RESULTS:Measures from the attention and executive domains were the most useful for identifying children with silent cerebral infarct. The Test of Variables of Attention was the most robust measure and yielded a sensitivity rate of 86% and a specificity rate of 81%. This measure also showed a sensitivity rate of 95% in identifying overt stroke. CONCLUSIONS:Brief cognitive screening measures, if properly constructed, may be an effective means of identifying children with silent cerebral infarct. Future prospective studies should be pursued to assess the utility of cognitive screening for silent cerebral infarcts in SCD.






DeBaun MR,Schatz J,Siegel MJ,Koby M,Craft S,Resar L,Chu JY,Launius G,Dadash-Zadeh M,Lee RB,Noetzel M




Has Abstract


1998-06-01 00:00:00












  • Rostral lateral pontine infarction: neurological/topographical correlations.

    abstract::The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...


    pub_type: 杂志文章


    authors: Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

    更新日期:2003-07-08 00:00:00

  • Prospective memory in patients with juvenile myoclonic epilepsy and their healthy siblings.

    abstract:OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...


    pub_type: 杂志文章


    authors: Wandschneider B,Kopp UA,Kliegel M,Stephani U,Kurlemann G,Janz D,Schmitz B

    更新日期:2010-12-14 00:00:00

  • Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.

    abstract::An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...


    pub_type: 杂志文章


    authors: Martinez JV,Mazziotti JV,Efron ED,Bonardo P,Jordan R,Sevlever G,Martinez M,Verbanaz SC,Salazar ZS,Pardal MF,Reisin R

    更新日期:2006-11-14 00:00:00

  • Pontine anosognosia for hemiplegia.

    abstract::Four patients had anosognosia for hemiplegia (AHP) as a manifestation of pontine infarction in the mediolateral region. Patients with AHP syndrome had no mental and neuropsychologic disturbances, and all had involvement of the medial or lateral part of the pons (medial or lateral pontine reticular nuclei). Brainstem l...


    pub_type: 杂志文章


    authors: Evyapan D,Kumral E

    更新日期:1999-08-11 00:00:00

  • Mineralization of the basal ganglia detected by CT in Hallervorden-Spatz syndrome.

    abstract::We studied a patient with autopsy-proven Hallervorden-Spatz syndrome (HSS) and the previously unreported finding of high-density lesions in the basal ganglia on CT. The diagnosis of HSS should be considered in a patient with dystonia and basal ganglia mineralization on CT. ...


    pub_type: 杂志文章


    authors: Tennison MB,Bouldin TW,Whaley RA

    更新日期:1988-01-01 00:00:00

  • Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups.

    abstract::We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...


    pub_type: 杂志文章


    authors: Klatka LA,Louis ED,Schiffer RB

    更新日期:1996-11-01 00:00:00

  • Primary hyperparathyroidism and ALS: is there a relation?

    abstract:BACKGROUND:An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. PATIENTS/METHODS:We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. I...


    pub_type: 杂志文章


    authors: Jackson CE,Amato AA,Bryan WW,Wolfe GI,Sakhaee K,Barohn RJ

    更新日期:1998-06-01 00:00:00

  • Reversible alexia, mitochondrial myopathy, and lactic acidemia.

    abstract::A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lacti...


    pub_type: 杂志文章


    authors: Skoglund RR

    更新日期:1979-05-01 00:00:00

  • HIV-1 infection: no evidence of cognitive decline during the asymptomatic stages. The Multicenter AIDS Cohort Study.

    abstract::Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfecte...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Selnes OA,Miller E,McArthur J,Gordon B,Muñoz A,Sheridan K,Fox R,Saah AJ

    更新日期:1990-02-01 00:00:00

  • Cerebral vasculitis and hemorrhage associated with phenylpropanolamine.

    abstract::A 20-year-old woman using an oral diet aid preparation containing phenylpropanolamine presented with an intracerebral hemorrhage and angiographic evidence of cerebral vasculitis. Gas chromatography demonstrated phenylpropanolamine in the urine. Even when used within recommended guidelines, phenylpropanolamine usage sh...


    pub_type: 杂志文章


    authors: Fallis RJ,Fisher M

    更新日期:1985-03-01 00:00:00

  • Predictors of incident epilepsy in older adults: The Cardiovascular Health Study.

    abstract:OBJECTIVE:To determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS). METHODS:We analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, ant...


    pub_type: 杂志文章


    authors: Choi H,Pack A,Elkind MS,Longstreth WT Jr,Ton TG,Onchiri F

    更新日期:2017-02-28 00:00:00

  • Antithrombotic treatment in patients with stroke and supracardiac atherosclerosis.

    abstract:OBJECTIVE:To compare the efficacy and safety of oral anticoagulants vs antiplatelets in patients with stroke and atherosclerotic plaques in the aortic arch or cervical or intracranial arteries, collectively described as supracardiac atherosclerosis. METHODS:We searched PubMed and Scopus until August 28, 2019, for rand...


    pub_type: 杂志文章,meta分析


    authors: Sagris D,Georgiopoulos G,Leventis I,Pateras K,Pearce LA,Korompoki E,Makaritsis K,Vemmos K,Milionis H,Ntaios G

    更新日期:2020-08-04 00:00:00

  • Syphilitic meningomyelitis.

    abstract::A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...


    pub_type: 杂志文章


    authors: Strom T,Schneck SA

    更新日期:1991-02-01 00:00:00

  • Adult-onset leukoencephalopathy with vanishing white matter with a missense mutation in EIF2B5.

    abstract::We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white mat...


    pub_type: 杂志文章


    authors: Ohtake H,Shimohata T,Terajima K,Kimura T,Jo R,Kaseda R,Iizuka O,Takano M,Akaiwa Y,Goto H,Kobayashi H,Sugai T,Muratake T,Hosoki T,Shioiri T,Okamoto K,Onodera O,Tanaka K,Someya T,Nakada T,Tsuji S

    更新日期:2004-05-11 00:00:00

  • Fat metabolism during exercise in patients with McArdle disease.

    abstract:OBJECTIVE:It is known that muscle phosphorylase deficiency restricts carbohydrate utilization, but the implications for muscle fat metabolism have not been studied. We questioned whether patients with McArdle disease can compensate for the blocked muscle glycogen breakdown by enhancing fat oxidation during exercise. M...


    pub_type: 杂志文章


    authors: Ørngreen MC,Jeppesen TD,Andersen ST,Taivassalo T,Hauerslev S,Preisler N,Haller RG,van Hall G,Vissing J

    更新日期:2009-02-24 00:00:00

  • A rating scale for Gilles de la Tourette's syndrome: description, reliability, and validity data.

    abstract::We developed a rating scale for tic disorders that uses only objective criteria and accommodates the variety of tic manifestations. Using short videotaped recordings with the examiner out of the taping room, we measured five tic variables: number of body areas affected, frequency of motor tics and vocalizations, and s...


    pub_type: 杂志文章


    authors: Goetz CG,Tanner CM,Wilson RS,Shannon KM

    更新日期:1987-09-01 00:00:00

  • An evaluation of the predictive validity and inter-rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type.

    abstract::Several recent autopsy studies suggest that senile dementia of Lewy body type (SDLT) may be the second most common neuropathologic cause of dementia in the elderly, accounting for 7 to 30% of all cases. Operational criteria for the antemortem clinical diagnosis of SDLT have already been proposed by our group. The perf...


    pub_type: 杂志文章


    authors: McKeith IG,Fairbairn AF,Bothwell RA,Moore PB,Ferrier IN,Thompson P,Perry RH

    更新日期:1994-05-01 00:00:00

  • Neoplastic meningitis-related encephalopathy: prognostic significance.

    abstract::Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in...


    pub_type: 杂志文章


    authors: Chamberlain MC,Tsao-Wei D,Groshen S

    更新日期:2004-12-14 00:00:00

  • Atypical nemaline myopathy with temporomandibular ankylosis.

    abstract::A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...


    pub_type: 杂志文章


    authors: Powers JM,Young GF,Bass EB Jr,Reed FE Jr

    更新日期:1980-09-01 00:00:00

  • Disease progression in sporadic inclusion body myositis: observations in 78 patients.

    abstract::Functional decline for each decade at symptom onset and need for cane, walker, or wheelchair were assessed in 78 biopsy-proved patients with sporadic inclusion body myositis. Patients with disease onset between 40 and 59 years used a walker after 10.2 +/- 5.8 years, whereas those with disease onset between 60 and 79 y...


    pub_type: 杂志文章


    authors: Peng A,Koffman BM,Malley JD,Dalakas MC

    更新日期:2000-07-25 00:00:00

  • Cytoplasmic inclusion bodies in superior rectus muscle of the eye.

    abstract::Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with...


    pub_type: 杂志文章


    authors: Culebras A,Merk FB

    更新日期:1975-05-01 00:00:00

  • Familial cerebellar ataxia with muscle coenzyme Q10 deficiency.

    abstract:OBJECTIVE:To describe a clinical syndrome of cerebellar ataxia associated with muscle coenzyme Q10 (CoQ10) deficiency. BACKGROUND:Muscle CoQ10 deficiency has been reported only in a few patients with a mitochondrial encephalomyopathy characterized by 1) recurrent myoglobinuria; 2) brain involvement (seizures, ataxia, ...


    pub_type: 杂志文章


    authors: Musumeci O,Naini A,Slonim AE,Skavin N,Hadjigeorgiou GL,Krawiecki N,Weissman BM,Tsao CY,Mendell JR,Shanske S,De Vivo DC,Hirano M,DiMauro S

    更新日期:2001-04-10 00:00:00

  • Psychogenic seizures: ictal characteristics and diagnostic pitfalls.

    abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...


    pub_type: 杂志文章


    authors: Leis AA,Ross MA,Summers AK

    更新日期:1992-01-01 00:00:00

  • Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice.

    abstract::We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...


    pub_type: 杂志文章


    authors: Walton NY,Treiman DM

    更新日期:1990-06-01 00:00:00

  • Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients.

    abstract::Juvenile myoclonic epilepsy (JME) is a distinct subform of idiopathic generalized epilepsy of adolescence. Linkage studies with Bf and serologic HLA markers in families of JME patients have shown a tight linkage on chromosome 6. We present a linkage analysis with HLA-DQ restriction fragment length polymorphisms on mor...


    pub_type: 杂志文章


    authors: Durner M,Sander T,Greenberg DA,Johnson K,Beck-Mannagetta G,Janz D

    更新日期:1991-10-01 00:00:00

  • The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment.

    abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...


    pub_type: 杂志文章


    authors: Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

    更新日期:2005-05-10 00:00:00

  • Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis.

    abstract:OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...


    pub_type: 杂志文章


    authors: Fuerst D,Shah J,Kupsky WJ,Johnson R,Shah A,Hayman-Abello B,Ergh T,Poore Q,Canady A,Watson C

    更新日期:2001-07-24 00:00:00

  • Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement.

    abstract::We performed 15 dynamic gadolinium-DTPA (Gd-DTPA)-enhanced MRI studies in 8 patients with relapsing and remitting multiple sclerosis; 7 were follow-up studies. We measured the time course of enhancement in 102 enhancing lesions for up to 384 minutes, with rest breaks. Immediate postcontrast MRIs demonstrated many diff...


    pub_type: 杂志文章


    authors: Kermode AG,Tofts PS,Thompson AJ,MacManus DG,Rudge P,Kendall BE,Kingsley DP,Moseley IF,du Boulay EP,McDonald WI

    更新日期:1990-02-01 00:00:00

  • Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia: clinical and biochemical studies.

    abstract::We performed a case-control study to investigate the role of recent infection as stroke risk factor and to identify pathogenetic pathways linking infection and stroke. We examined 166 consecutive patients with acute cerebrovascular ischemia and 166 patients hospitalized for nonvascular and noninflammatory neurologic d...


    pub_type: 杂志文章


    authors: Grau AJ,Buggle F,Becher H,Zimmermann E,Spiel M,Fent T,Maiwald M,Werle E,Zorn M,Hengel H,Hacke W

    更新日期:1998-01-01 00:00:00

  • Practical considerations in the use of apomorphine injectable.

    abstract::This manuscript provides a practical summary of guidelines for institution of apomorphine subcutaneous injectable therapy, including patient education, pre-treatment issues, dosage titration and side-effect care. The timing of each injection is crucial if an impending "off" period is to be averted. Patients need to be...


    pub_type: 杂志文章,评审


    authors: Bowron A

    更新日期:2004-03-23 00:00:00