Abstract:
:Four patients developed postural tremor after ingestion of sodium valproate. The tremor was recorded by a variable-capacitance transducer and was of the "benign essential" type. The dosages of sodium valproate varied between 1000 mg and 2000 mg daily and serum levels were between 34.9 microgram per milliliter and 154.3 microgram per milliliter. Tremor was ameliorated in two cases when the dosage was reduced. In only one case was the serum level in the toxic range for our laboratory. The pharmacology of essential tremor is unknown; production of a similar tremor by a drug could serve as a biochemical model.
journal_name
Neurologyjournal_title
Neurologyauthors
Hyman NM,Dennis PD,Sinclair KGdoi
10.1212/wnl.29.8.1177subject
Has Abstractpub_date
1979-08-01 00:00:00pages
1177-80issue
8eissn
0028-3878issn
1526-632Xjournal_volume
29pub_type
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