Tremor due to sodium valproate.

Abstract:

:Four patients developed postural tremor after ingestion of sodium valproate. The tremor was recorded by a variable-capacitance transducer and was of the "benign essential" type. The dosages of sodium valproate varied between 1000 mg and 2000 mg daily and serum levels were between 34.9 microgram per milliliter and 154.3 microgram per milliliter. Tremor was ameliorated in two cases when the dosage was reduced. In only one case was the serum level in the toxic range for our laboratory. The pharmacology of essential tremor is unknown; production of a similar tremor by a drug could serve as a biochemical model.

journal_name

Neurology

journal_title

Neurology

authors

Hyman NM,Dennis PD,Sinclair KG

doi

10.1212/wnl.29.8.1177

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

1177-80

issue

8

eissn

0028-3878

issn

1526-632X

journal_volume

29

pub_type

杂志文章
  • Comparison of Phenotypic Characteristics and Prognosis Between Black and White Patients in a Tertiary ALS Clinic.

    abstract:OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were in...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011396

    authors: Brand D,Polak M,Glass JD,Fournier CN

    更新日期:2020-12-28 00:00:00

  • Reduction in voice tremor under thalamic stimulation.

    abstract::We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.50.3.796

    authors: Carpenter MA,Pahwa R,Miyawaki KL,Wilkinson SB,Searl JP,Koller WC

    更新日期:1998-03-01 00:00:00

  • Dystonic posturing in seizures of mesial temporal origin: electroclinical and metabolic patterns.

    abstract:OBJECTIVE:To test the hypothesis that extratemporal neuronal networks are involved in dystonic posturing (DP) observed in mesial temporal epilepsy (MTLE). METHODS:The authors analyzed electroclinical findings in 36 patients with MTLE with or without DP. Three DP types were defined (types I, II, III) corresponding to a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000184510.44808.50

    authors: Rusu V,Chassoux F,Landré E,Bouilleret V,Nataf F,Devaux BC,Turak B,Semah F

    更新日期:2005-11-22 00:00:00

  • Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume.

    abstract:OBJECTIVE:To compare the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and CT perfusion to detect established infarction in acute anterior circulation stroke. METHODS:We performed an observational study in 59 acute anterior circulation ischemic stroke patients who underwent brain noncont...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004028

    authors: Demeestere J,Garcia-Esperon C,Garcia-Bermejo P,Ombelet F,McElduff P,Bivard A,Parsons M,Levi C

    更新日期:2017-06-13 00:00:00

  • Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

    abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0b013e31829c5cfe

    authors: Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

    更新日期:2013-07-23 00:00:00

  • Feasibility and validity of computerized ambulatory monitoring in stroke patients.

    abstract:BACKGROUND:Computerized ambulatory monitoring provides real-time assessments of clinical outcomes in natural contexts, and it has been increasingly applied in recent years to investigate symptom expression in a wide range of disorders. The purpose of this study was to examine the feasibility and validity of this data c...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181c0d466

    authors: Johnson EI,Sibon I,Renou P,Rouanet F,Allard M,Swendsen J

    更新日期:2009-11-10 00:00:00

  • Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.

    abstract:OBJECTIVE:To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS:We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.51.1.125

    authors: Ishii K,Imamura T,Sasaki M,Yamaji S,Sakamoto S,Kitagaki H,Hashimoto M,Hirono N,Shimomura T,Mori E

    更新日期:1998-07-01 00:00:00

  • Risk of premature stroke in recent immigrants (PRESARIO): population-based matched cohort study.

    abstract:BACKGROUND:New immigrants to North America, most of whom are under age 50 years, exhibit fewer risk factors for cardiovascular disease than their native-born counterparts, yet the stress of resettlement may conceivably place them at higher risk of stroke. We determined the risk of acute stroke associated with recency o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181cf6e9e

    authors: Saposnik G,Redelmeier DA,Lu H,Lonn E,Fuller-Thomson E,Ray JG

    更新日期:2010-02-09 00:00:00

  • Competency to consent to medical treatment in cognitively impaired patients with Parkinson's disease.

    abstract:OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.1.17

    authors: Dymek MP,Atchison P,Harrell L,Marson DC

    更新日期:2001-01-09 00:00:00

  • Ring and nodular multiple sclerosis lesions: a retrospective natural history study.

    abstract:BACKGROUND:In patients with multiple sclerosis (MS), contrast-enhancing lesions (CELs) on postcontrast MRI are considered markers of the inflammatory responses associated with blood-brain barrier breakdown. Based upon shape, CELs may be defined as nodular (nCEL) or ring (rCEL) lesions. Several short-term studies pointe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181d31df5

    authors: Davis M,Auh S,Riva M,Richert ND,Frank JA,McFarland HF,Bagnato F

    更新日期:2010-03-09 00:00:00

  • Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.

    abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008696

    authors: Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

    更新日期:2020-01-07 00:00:00

  • High risk of postpartum relapses in neuromyelitis optica spectrum disorder.

    abstract:OBJECTIVE:To study the effect of pregnancy on the frequency of neuromyelitis optica spectrum disorder (NMOSD) relapse and evaluate rates of pregnancy-related complications in an international multicenter setting. METHODS:We administered a standardized survey to 217 women with NMOSD from 7 medical centers and reviewed ...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000004681

    authors: Klawiter EC,Bove R,Elsone L,Alvarez E,Borisow N,Cortez M,Mateen F,Mealy MA,Sorum J,Mutch K,Tobyne SM,Ruprecht K,Buckle G,Levy M,Wingerchuk D,Paul F,Cross AH,Jacobs A,Chitnis T,Weinshenker B

    更新日期:2017-11-28 00:00:00

  • Altered pharmacokinetics of L-dopa metabolism in rat striatum deprived of dopaminergic innervation.

    abstract::Rats with unilateral lesions of the substantia nigra were treated with L-dopa 25 mg/kg subcutaneously 30 minutes after treatment with carbidopa 25 mg/kg intraperitoneally. In the ipsilateral striatum, dopamine levels achieved a peak of 1.57 +/- 0.63 micrograms/g (control 0.19 +/- 0.05 micrograms/g) at 20 minutes and d...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.8.1105

    authors: Spencer SE,Wooten GF

    更新日期:1984-08-01 00:00:00

  • Central nervous system involvement in dengue: a study in fatal cases from a dengue endemic area.

    abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824b94e9

    authors: Araújo FM,Araújo MS,Nogueira RM,Brilhante RS,Oliveira DN,Rocha MF,Cordeiro RA,Araújo RM,Sidrim JJ

    更新日期:2012-03-06 00:00:00

  • Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study.

    abstract:OBJECTIVE:To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS:The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995....

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.9.1350

    authors: Benedetti MD,Bower JH,Maraganore DM,McDonnell SK,Peterson BJ,Ahlskog JE,Schaid DJ,Rocca WA

    更新日期:2000-11-14 00:00:00

  • Numb chin syndrome secondary to Burkitt's cell acute leukemia.

    abstract::We describe a case of Burkitt's cell acute lymphoblastic leukemia presenting with the bilateral numb chin syndrome as the initial symptom of the disease. Postmortem study of the trigeminal nerve showed heavy infiltrations of leukemic cells and destruction of axon and myelin by leukemic cells in the mandibular nerve. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.3.453

    authors: Kuroda Y,Fujiyama F,Ohyama T,Watanabe T,Endo C,Neshige R,Kakigi R

    更新日期:1991-03-01 00:00:00

  • Selective deficit of praxis imagery in ideomotor apraxia.

    abstract::We studied imagery for learned, skilled movements (praxis imagery) in a patient with severe ideomotor apraxia and intact language abilities. This patient, who made predominantly spatial and movement errors when performing transitive movements demonstrating the use of tools (transitive gestures), was also impaired in h...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.2.474

    authors: Ochipa C,Rapcsak SZ,Maher LM,Rothi LJ,Bowers D,Heilman KM

    更新日期:1997-08-01 00:00:00

  • A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

    abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.55.6.805

    authors: Thal LJ,Calvani M,Amato A,Carta A

    更新日期:2000-09-26 00:00:00

  • Pharmacologic management of seizures in organ transplant.

    abstract::Seizures in a transplant candidate or recipient raise complicated management issues, but there are no results from controlled drug trials to guide their pharmacologic treatment. Most seizures in the transplant population are isolated events that do not require long-term antiseizure therapy. Short-term therapy, however...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.67.12_suppl_4.s34

    authors: Chabolla DR,Wszolek ZK

    更新日期:2006-12-26 00:00:00

  • MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease.

    abstract::We evaluated a new magnetic resonance (MR)-based technique for performing volumetric measurements of temporal lobe structures. The technique was designed to assist in making the clinical diagnosis of dementia of the Alzheimer type (DAT). We chose specific anatomic regions of interest because of their known involvement...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.1.183

    authors: Jack CR Jr,Petersen RC,O'Brien PC,Tangalos EG

    更新日期:1992-01-01 00:00:00

  • Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

    abstract:OBJECTIVE:To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). METHODS:We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in patients with ALS with first symptom onset...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000004761

    authors: Feneberg E,Oeckl P,Steinacker P,Verde F,Barro C,Van Damme P,Gray E,Grosskreutz J,Jardel C,Kuhle J,Koerner S,Lamari F,Amador MDM,Mayer B,Morelli C,Muckova P,Petri S,Poesen K,Raaphorst J,Salachas F,Silani V,Stuben

    更新日期:2018-01-02 00:00:00

  • Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures.

    abstract:OBJECTIVE:To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls. METHODS:We included 64 patients with AD (67 +/- 9 years; F/M 38/26), 44 patients with MCI (71 +/- 6 yea...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000344568.09360.31

    authors: Henneman WJ,Sluimer JD,Barnes J,van der Flier WM,Sluimer IC,Fox NC,Scheltens P,Vrenken H,Barkhof F

    更新日期:2009-03-17 00:00:00

  • Neurologic complications after gastric restriction surgery for morbid obesity.

    abstract::We report the occurrence of neurologic complications in 23 patients who underwent gastric restriction surgery for the treatment of morbid obesity. Complications occurred 3 to 20 months after surgery. All the patients had had protracted vomiting for the first 3 months after the operation. The following syndromes were f...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.2.196

    authors: Abarbanel JM,Berginer VM,Osimani A,Solomon H,Charuzi I

    更新日期:1987-02-01 00:00:00

  • Rate of spontaneous resolution of a solitary cysticercus granuloma in patients with seizures.

    abstract::The rate of spontaneous resolution of a recently diagnosed solitary cerebral cysticercus granuloma as visualized on CT scan was prospectively studied in 210 patients presenting with seizures. The proportion of granulomas that had resolved completely at different time intervals after the index scan was 18.8% at 3 month...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.12.2315

    authors: Rajshekhar V

    更新日期:2001-12-26 00:00:00

  • Band heterotopia or double cortex in a male: bridging structures suggest abnormality of the radial glial guide system.

    abstract::A moderately retarded Japanese boy, with a normal male karyotype (46,XY), was diagnosed to have a subcortical band heterotopia or double cortex syndrome. The band heterotopia was relatively thick compared with that of other patients reported. On T2-weighted coronal MR sections, there were numerous radial linear struct...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.6.1701

    authors: Ono J,Mano T,Andermann E,Harada K,Sakurai K,Ikeda T,Yoshihara N,Shimizu K,Okada S,Andermann F

    更新日期:1997-06-01 00:00:00

  • Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children.

    abstract:OBJECTIVE:Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half of the patients. This study aimed to evaluate the effect of oral folic acid supplementation (0.5 mg/day) for the prevention of PHT-induced gingival overgrowth (PIGO) in children with epilepsy aged 6-15 years...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0b013e3182152844

    authors: Arya R,Gulati S,Kabra M,Sahu JK,Kalra V

    更新日期:2011-04-12 00:00:00

  • Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, January 1, 1975.

    abstract::Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.6.773

    authors: Kokmen E,Beard CM,Offord KP,Kurland LT

    更新日期:1989-06-01 00:00:00

  • Mutations in GABRB3: From febrile seizures to epileptic encephalopathies.

    abstract:OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003565

    authors: Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

    更新日期:2017-01-31 00:00:00

  • Use of antithrombotic drugs in the treatment of acute ischemic stroke: a survey of neurologists in practice in the United States.

    abstract::In an attempt to determine the opinions and practices of neurologists regarding the use of antithrombotic drugs in the treatment of acute ischemic stroke, we conducted a survey of 349 randomly selected neurologists from throughout the United States. Responses were received from 247 (71%), and 219 identified themselves...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.12.1631

    authors: Marsh EE 3rd,Adams HP Jr,Biller J,Wasek P,Banwart K,Mitchell V,Woolson R

    更新日期:1989-12-01 00:00:00

  • Body mass index and the risk of Parkinson disease.

    abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000247052.18422.e5

    authors: Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

    更新日期:2006-12-12 00:00:00