Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis.

Abstract:

:Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable to the diseased ICA. In the so-defined neurologically symptomatic group (n = 33 patients), silent microembolic events occurred in 27 subjects (overall mean rate, 14/h +/- 29). Among 56 neurologically asymptomatic patients matched for the degree of ICA stenosis, only nine showed such events (overall mean rate, 0.35/h +/- 1.4). Across all 89 patients studied, an individual microembolic event rate > or = 2/h had a positive predictive value of 0.88 for a history of recent symptoms. Our data suggest that TCD monitoring can provide reliable paraclinical evidence of "unstable ICA disease."

journal_name

Neurology

journal_title

Neurology

authors

Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

doi

10.1212/wnl.44.4.615

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

615-8

issue

4

eissn

0028-3878

issn

1526-632X

journal_volume

44

pub_type

杂志文章
  • Effects of prostaglandins on cerebral blood vessels: interaction with vasoactive amines.

    abstract::Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.25.12.1169

    authors: Rosenblum WI

    更新日期:1975-12-01 00:00:00

  • The effects of storage and shaking on the settling properties of phenytoin suspension.

    abstract::Phenytoin suspension (PHY-S) is reported to settle, resulting in uneven drug distribution and variable patient dosing. We designed this study to determine the rate of settling and the amount of agitation needed to resuspend the preparation. To determine the rate of settling, we thoroughly shook three bottles of PHY-S ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.2.207

    authors: Sarkar MA,Garnett WR,Karnes HT

    更新日期:1989-02-01 00:00:00

  • Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, January 1, 1975.

    abstract::Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.6.773

    authors: Kokmen E,Beard CM,Offord KP,Kurland LT

    更新日期:1989-06-01 00:00:00

  • Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures.

    abstract:BACKGROUND:Previous studies have suggested a variety of factors that may be associated with the presence of hippocampal formation (HF) atrophy in patients with complex partial seizures (CPS), including a history of complex or prolonged febrile seizures (FS), age at seizure onset, and epilepsy duration. OBJECTIVE:To de...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.1.132

    authors: Theodore WH,Bhatia S,Hatta J,Fazilat S,DeCarli C,Bookheimer SY,Gaillard WD

    更新日期:1999-01-01 00:00:00

  • Apolipoprotein E gene and sporadic frontal lobe dementia.

    abstract::The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.6.1526

    authors: Stevens M,van Duijn CM,de Knijff P,van Broeckhoven C,Heutink P,Oostra BA,Niermeijer MF,van Swieten JC

    更新日期:1997-06-01 00:00:00

  • Timing of milestone competency acquisition in neurology residency: What by when?

    abstract:OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006361

    authors: Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

    更新日期:2018-10-16 00:00:00

  • Serum-mediated Schwann cell cytotoxicity in the Guillain-Barré syndrome.

    abstract::To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.9.1240

    authors: Lisak RP,Kuchmy D,Armati-Gulson PJ,Brown MJ,Sumner AJ

    更新日期:1984-09-01 00:00:00

  • Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage.

    abstract:OBJECTIVE:We tested the hypothesis that admission serum magnesium levels are associated with hematoma volume, hematoma growth, and functional outcomes in patients with intracerebral hemorrhage (ICH). METHODS:Patients presenting with spontaneous ICH were enrolled in an observational cohort study that prospectively coll...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004249

    authors: Liotta EM,Prabhakaran S,Sangha RS,Bush RA,Long AE,Trevick SA,Potts MB,Jahromi BS,Kim M,Manno EM,Sorond FA,Naidech AM,Maas MB

    更新日期:2017-08-22 00:00:00

  • Exploratory saccades show no direction-specific deficit in neglect.

    abstract::In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.2.515

    authors: Niemeier M,Karnath HO

    更新日期:2000-01-25 00:00:00

  • Simple partial seizures: clinicofunctional correlation--a case report.

    abstract::A 12-year-old girl developed simple partial motor and sensory seizures due to a right perirolandic astrocytoma. Subdural EEG recording and functional stimulation disclosed close correlation between EEG-clinical manifestations of focal seizures and functional responses to cortical stimulation. This case supports the id...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.3.642

    authors: Arroyo S,Krauss GL,Lesser RP,Gordon B,Hart J Jr,Carson BS,Uematsu S

    更新日期:1992-03-01 00:00:00

  • Petasites hybridus root (butterbur) is an effective preventive treatment for migraine.

    abstract:OBJECTIVE:To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS:This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients wit...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000147290.68260.11

    authors: Lipton RB,Göbel H,Einhäupl KM,Wilks K,Mauskop A

    更新日期:2004-12-28 00:00:00

  • Association of APOE polymorphisms with disease severity in MS is limited to women.

    abstract::The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*epsilon2 allele took longer to att...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000113721.83287.83

    authors: Kantarci OH,Hebrink DD,Achenbach SJ,Pittock SJ,Altintas A,Schaefer-Klein JL,Atkinson EJ,De Andrade M,McMurray CT,Rodriguez M,Weinshenker BG

    更新日期:2004-03-09 00:00:00

  • Sodium valproate: serial monitoring of EEG and serum levels.

    abstract::The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.11.1450

    authors: Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

    更新日期:1979-11-01 00:00:00

  • The "sinister" Tolosa-Hunt syndrome.

    abstract::Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.2.198

    authors: Spector RH,Fiandaca MS

    更新日期:1986-02-01 00:00:00

  • Accuracy of family history information on epilepsy and other seizure disorders.

    abstract:BACKGROUND:In epilepsy as in other disorders, family history information is often obtained by asking patients about the medical histories of their relatives rather than interviewing or examining the relatives directly. The accuracy of this type of information for epilepsy and other seizure disorders is unclear. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182088286

    authors: Ottman R,Barker-Cummings C,Leibson CL,Vasoli VM,Hauser WA,Buchhalter JR

    更新日期:2011-01-25 00:00:00

  • Meningeal gliomatosis with "negative" CSF cytology: the value of GFAP staining.

    abstract::We report a patient with meningeal gliomatosis who had signs of meningitis, hypoglycorrhachia, and an intracranial mass. Despite suspicion of a primary intracranial neoplasm, repeated CSF cytologies were not diagnostic and led to a brain biopsy for diagnosis. Immunoperoxidase staining for glial fibrillary acidic prote...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.12.1611

    authors: Wechsler LR,Gross RA,Miller DC

    更新日期:1984-12-01 00:00:00

  • Stroke with sensory symptoms mimicking myocardial ischemia.

    abstract:OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.46.2.548

    authors: Gorson KC,Pessin MS,DeWitt LD,Caplan LR

    更新日期:1996-02-01 00:00:00

  • Neonatal Guillain-Barré syndrome: blocking antibodies transmitted from mother to child.

    abstract:OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.6.1246

    authors: Buchwald B,de Baets M,Luijckx GJ,Toyka KV

    更新日期:1999-10-12 00:00:00

  • Brain mechanisms of successful compensation during learning in Alzheimer disease.

    abstract:OBJECTIVE:To determine whether patients with Alzheimer disease (AD) compensate for neuropathologic changes when performing a mnemonic task by recruiting 1) the same brain regions as age-matched, healthy controls, but to a greater extent; 2) additional brain regions not activated by controls; or 3) both. METHODS:Twelve...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000237534.31734.1b

    authors: Gould RL,Arroyo B,Brown RG,Owen AM,Bullmore ET,Howard RJ

    更新日期:2006-09-26 00:00:00

  • Detection of Borrelia burgdorferi-specific antigen in antibody-negative cerebrospinal fluid in neurologic Lyme disease.

    abstract:OBJECTIVE:To determine the potential of detection in CSF of specific Borrelia burgdorferi antigen, OspA, as a marker of infection in neurologic Lyme disease and compare this with the detection of antibody. DESIGN:CSF from 83 neurologic patients in an area highly endemic for Lyme disease was examined prospectively for ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.11.2010

    authors: Coyle PK,Schutzer SE,Deng Z,Krupp LB,Belman AL,Benach JL,Luft BJ

    更新日期:1995-11-01 00:00:00

  • Sixty hertz pallidal deep brain stimulation for primary torsion dystonia.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000267430.95106.ff

    authors: Alterman RL,Miravite J,Weisz D,Shils JL,Bressman SB,Tagliati M

    更新日期:2007-08-14 00:00:00

  • Neutralizing antibodies reduce the efficacy of betaIFN during treatment of multiple sclerosis.

    abstract:OBJECTIVE:To analyze the impact of neutralizing antibodies (NAbs) on the clinical efficacy of IFNbeta. METHODS:This was an open-label study involving 78 patients with multiple sclerosis treated with Betaferon 8 million IU (MIU) subcutaneously (SC) every other day (n = 20), Rebif 22 micro g SC 3 times weekly (n = 25), ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000129265.73259.9e

    authors: Malucchi S,Sala A,Gilli F,Bottero R,Di Sapio A,Capobianco M,Bertolotto A

    更新日期:2004-06-08 00:00:00

  • Recovery after spinal cord infarcts: long-term outcome in 115 patients.

    abstract:OBJECTIVE:To investigate the long-term outcome of patients with spinal cord infarct (SCI) and identify prognostic predictors. METHODS:We reviewed 115 patients with SCI treated between 1990 and 2007. Severity of impairment was defined using the American Spinal Injury Association (ASIA) scoring. Functional outcome endpo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31823efc93

    authors: Robertson CE,Brown RD Jr,Wijdicks EF,Rabinstein AA

    更新日期:2012-01-10 00:00:00

  • Altered polyamine excretion in Duchenne muscular dystrophy.

    abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:

    authors: Russell DH,Stern LZ

    更新日期:1981-01-01 00:00:00

  • Nonseptic cardiogenic cerebral embolic stroke: clinical-CT correlations.

    abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.6.896

    authors: Weisberg LA

    更新日期:1985-06-01 00:00:00

  • Incidence and prevalence of small-fiber neuropathy: a survey in the Netherlands.

    abstract:OBJECTIVE:To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands. METHODS:In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182a8236e

    authors: Peters MJ,Bakkers M,Merkies IS,Hoeijmakers JG,van Raak EP,Faber CG

    更新日期:2013-10-08 00:00:00

  • Homozygosity for the transthyretin-Met30 gene in three Japanese siblings with type I familial amyloidotic polyneuropathy.

    abstract::We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.10.2045

    authors: Yoshinaga T,Nakazato M,Ikeda S,Ohnishi A

    更新日期:1992-10-01 00:00:00

  • Survival in Alzheimer disease: a multiethnic, population-based study of incident cases.

    abstract:OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000334278.11022.42

    authors: Helzner EP,Scarmeas N,Cosentino S,Tang MX,Schupf N,Stern Y

    更新日期:2008-11-04 00:00:00

  • Increasing comorbidity and health services utilization in older adults with prior stroke.

    abstract:OBJECTIVE:To characterize comorbid chronic conditions, describe health services use, and estimate health care costs among community-dwelling older adults with prior stroke. METHODS:This is a retrospective cohort study using administrative data from Ontario, Canada. We identified all community-dwelling individuals aged...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003329

    authors: Gruneir A,Griffith LE,Fisher K,Panjwani D,Gandhi S,Sheng L,Patterson C,Gafni A,Ploeg J,Markle-Reid M

    更新日期:2016-11-15 00:00:00

  • Muscle phosphorylase kinase deficiency: a neutral metabolic variant or a disease?

    abstract:OBJECTIVE:To examine metabolism during exercise in 2 patients with muscle phosphorylase kinase (PHK) deficiency and to further define the phenotype of this rare glycogen storage disease (GSD). METHODS:Patient 1 (39 years old) had mild exercise-induced forearm pain, and EMG showed a myopathic pattern. Patient 2 (69 yea...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824365f9

    authors: Preisler N,Orngreen MC,Echaniz-Laguna A,Laforet P,Lonsdorfer-Wolf E,Doutreleau S,Geny B,Akman HO,Dimauro S,Vissing J

    更新日期:2012-01-24 00:00:00