Abstract:
:Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable to the diseased ICA. In the so-defined neurologically symptomatic group (n = 33 patients), silent microembolic events occurred in 27 subjects (overall mean rate, 14/h +/- 29). Among 56 neurologically asymptomatic patients matched for the degree of ICA stenosis, only nine showed such events (overall mean rate, 0.35/h +/- 1.4). Across all 89 patients studied, an individual microembolic event rate > or = 2/h had a positive predictive value of 0.88 for a history of recent symptoms. Our data suggest that TCD monitoring can provide reliable paraclinical evidence of "unstable ICA disease."
journal_name
Neurologyjournal_title
Neurologyauthors
Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJdoi
10.1212/wnl.44.4.615subject
Has Abstractpub_date
1994-04-01 00:00:00pages
615-8issue
4eissn
0028-3878issn
1526-632Xjournal_volume
44pub_type
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