Subacute sclerosing panencephalitis: measles virus matrix protein nucleic acid sequences detected by in situ hybridization.

Abstract:

:Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cells and neurons of cryostat sections from two SSPE brains. In one SSPE brain, M protein was lacking, but the other measles polypeptides were present. IgG and IgM antibodies eluted from that brain lacked antibodies to M protein, but antibodies to other measles polypeptides were present. In SSPE brain, the viral M-protein defect is not a deletion of the M gene, but rather a block in gene expression.

journal_name

Neurology

journal_title

Neurology

authors

Shapshak P,Tourtellotte WW,Nakamura S,Graves MC,Darvish M,Hoffman D,Walsh MJ,Fareed GC,Schmid P,Heinzmann C

doi

10.1212/wnl.35.11.1605

subject

Has Abstract,Author List Incomplete

pub_date

1985-11-01 00:00:00

pages

1605-9

issue

11

eissn

0028-3878

issn

1526-632X

journal_volume

35

pub_type

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