Failure of cholinergic agonist RS-86 to improve cognition and movement in PSP despite effects on sleep.

abstract：:I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...

journal_title：Neurology

authors： Sarnat HB

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:To determine the relative efficacy of amantadine, pemoline, and placebo in treatment of multiple sclerosis (MS)-related fatigue. BACKGROUND:Fatigue is a complication of MS. Both pemoline and amantadine have been used to treat MS fatigue, but their relative efficacy is not known. METHODS:Amantadine, pemoline...

journal_title：Neurology

authors： Krupp LB,Coyle PK,Doscher C,Miller A,Cross AH,Jandorf L,Halper J,Johnson B,Morgante L,Grimson R

更新日期：1995-11-01 00:00:00

abstract：:We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...

journal_title：Neurology

authors： Torno M,Vollmer M,Beck CK

更新日期：2007-02-13 00:00:00

abstract：:The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...

journal_title：Neurology

authors： Bonafé L,Blau N,Burlina AP,Romstad A,Güttler F,Burlina AB

更新日期：2001-09-11 00:00:00

abstract：:Several recent autopsy studies suggest that senile dementia of Lewy body type (SDLT) may be the second most common neuropathologic cause of dementia in the elderly, accounting for 7 to 30% of all cases. Operational criteria for the antemortem clinical diagnosis of SDLT have already been proposed by our group. The perf...

journal_title：Neurology

authors： McKeith IG,Fairbairn AF,Bothwell RA,Moore PB,Ferrier IN,Thompson P,Perry RH

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:While stable xenon CT (Xe-CT) cerebral blood flow (CBF) is an accepted standard for quantitative assessment of cerebral hemodynamics, the accuracy of magnetic resonance perfusion-weighted imaging (PWI-MRI) is unclear. The Improved PWI Methodology in Acute Clinical Stroke Study compares PWI findings with Xe-C...

journal_title：Neurology

authors： Olivot JM,Mlynash M,Zaharchuk G,Straka M,Bammer R,Schwartz N,Lansberg MG,Moseley ME,Albers GW

更新日期：2009-03-31 00:00:00

abstract：:The authors retrospectively reviewed the efficacy of mycophenolate mofetil (MMF; mean dose, 2 g/day given for an average of 14 months) in 21 patients with immune demyelinating polyneuropathy. There were no significant differences in the median strength, sensory, or Rankin scores before and after treatment. In patients...

journal_title：Neurology

authors： Gorson KC,Amato AA,Ropper AH

更新日期：2004-08-24 00:00:00

abstract：OBJECTIVES:To define CSF β-amyloid 1-42 (Aβ42) cutpoints to detect cortical amyloid deposition as assessed by 11C-Pittsburgh compound B ([11C]PiB)-PET and to compare these calculated cutpoints with cutpoints currently used in clinical practice. METHODS:We included 433 participants (57 controls, 99 with mild cognitive ...

journal_title：Neurology

authors： Zwan MD,Rinne JO,Hasselbalch SG,Nordberg A,Lleó A,Herukka SK,Soininen H,Law I,Bahl JM,Carter SF,Fortea J,Blesa R,Teunissen CE,Bouwman FH,van Berckel BN,Visser PJ

更新日期：2016-01-05 00:00:00

abstract：:We obtained continuous EEG/video recordings on four children who had the interictal EEG pattern of multifocal independent epileptiform discharges (MIED). The prominent feature of their evaluation was the evidence that their clinical seizures appeared to be of focal origin; 42/44 seizures were manifested by "fencing po...

journal_title：Neurology

authors： Burnstine TH,Vining EP,Uematsu S,Lesser RP

更新日期：1991-08-01 00:00:00

abstract：:A 52-year-old steelworker displayed a consistent defect in leftward voluntary gaze across the midline. Both fast (saccadic) and slow (pursuit) eye movements were affected. Neuro-ophthalmologic evaluation revealed no additional neurologic or ophthalmologic deficit. Pupilary miosis occurred during leftward gaze attempt,...

journal_title：Neurology

authors： Troost BT,Troost EG

更新日期：1979-01-01 00:00:00

abstract：:Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated...

journal_title：Neurology

authors： Hatanpaa KJ,Blass DM,Pletnikova O,Crain BJ,Bigio EH,Hedreen JC,White CL 3rd,Troncoso JC

更新日期：2004-08-10 00:00:00

abstract：:We examined correlates of depression in patients whose onset of Parkinson's disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). The early-onset group showed a significantly higher frequency of depression than the late-onset group. When both group...

journal_title：Neurology

authors： Starkstein SE,Berthier ML,Bolduc PL,Preziosi TJ,Robinson RG

更新日期：1989-11-01 00:00:00

abstract：:We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability...

journal_title：Neurology

authors： Yesavage JA,Mumenthaler MS,Taylor JL,Friedman L,O'Hara R,Sheikh J,Tinklenberg J,Whitehouse PJ

更新日期：2002-07-09 00:00:00

abstract：:Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed o...

journal_title：Neurology

authors： Halperin JJ,Golightly M

更新日期：1992-07-01 00:00:00

abstract：:In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...

journal_title：Neurology

authors： Diederich N,Goetz CG,Stebbins GT,Klawans HL,Nittner K,Koulosakis A,Sanker P,Sturm V

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To ascertain the prevalence and determinants of neuropathy in patients with Parkinson disease (PD), in particular, the roles of vitamin B12 and levodopa exposure. METHODS:We performed a cross-sectional study of 37 patients with PD and 37 age- and gender-matched controls, using a sensitive and validated neuro...

journal_title：Neurology

authors： Rajabally YA,Martey J

更新日期：2011-11-29 00:00:00

abstract：:This multicenter, double-blind, crossover study compared Tegretol-XR and Tegretol tablets with respect to trough plasma carbamazepine (CBZ) concentrations, seizure control, tolerability, and safety. We randomized 96 patients with epilepsy to 56-day monotherapy with their usual daily CBZ dose administered as (1) Tegret...

journal_title：Neurology

authors：

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:We sought to develop and validate a risk index for prospective cognitive decline in older adults based on blood-derived markers. METHODS:The index was based on 8 markers that have been previously associated with cognitive aging: APOE genotype, plasma β-amyloid 42/40 ratio, telomere length, cystatin C, glucos...

journal_title：Neurology

authors： Nettiksimmons J,Ayonayon H,Harris T,Phillips C,Rosano C,Satterfield S,Yaffe K,Health ABC Study.

更新日期：2015-02-17 00:00:00

abstract：OBJECTIVE:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, w...

journal_title：Neurology

authors： Chen JJ,Flanagan EP,Bhatti MT,Jitprapaikulsan J,Dubey D,Lopez Chiriboga ASS,Fryer JP,Weinshenker BG,McKeon A,Tillema JM,Lennon VA,Lucchinetti CF,Kunchok A,McClelland CM,Lee MS,Bennett JL,Pelak VS,Van Stavern G,Adesina

更新日期：2020-07-14 00:00:00

abstract：:When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...

journal_title：Neurology

authors： Shakir R,Bergen D

更新日期：2013-07-09 00:00:00

abstract：:In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high...

journal_title：Neurology

authors： Troiano RA,Jotkowitz A,Cook SD,Bansil S,Zito G

更新日期：1992-07-01 00:00:00

abstract：:MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...

journal_title：Neurology

authors： Takanashi J,Barkovich AJ,Ferriero DM,Suzuki H,Kohno Y

更新日期：2003-08-26 00:00:00

abstract：:We examined the baseline characteristics of patients in the Ticlopidine Aspirin Stroke Study (TASS) to determine if the effects of the two treatments in preventing stroke differed in various subgroups. Patients with the following characteristics did less well on aspirin: elevated creatinine, hypertension or diabetes r...

journal_title：Neurology

authors： Grotta JC,Norris JW,Kamm B

更新日期：1992-01-01 00:00:00

abstract：:In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...

journal_title：Neurology

authors： Van den Berg LH,Franssen H,Wokke JH

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To characterize comorbid chronic conditions, describe health services use, and estimate health care costs among community-dwelling older adults with prior stroke. METHODS:This is a retrospective cohort study using administrative data from Ontario, Canada. We identified all community-dwelling individuals aged...

journal_title：Neurology

authors： Gruneir A,Griffith LE,Fisher K,Panjwani D,Gandhi S,Sheng L,Patterson C,Gafni A,Ploeg J,Markle-Reid M

更新日期：2016-11-15 00:00:00

abstract：OBJECTIVE:To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS:We defined ...

journal_title：Neurology

authors： Pasi M,Boulouis G,Fotiadis P,Auriel E,Charidimou A,Haley K,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...

journal_title：Neurology

authors： Helmchen C,Rambold H,Kempermann U,Büttner-Ennever JA,Büttner U

更新日期：2002-12-24 00:00:00

abstract：OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...

journal_title：Neurology

authors： Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

更新日期：2005-09-27 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...

journal_title：Neurology

authors： Lochmüller H,Behin A,Caraco Y,Lau H,Mirabella M,Tournev I,Tarnopolsky M,Pogoryelova O,Woods C,Lai A,Shah J,Koutsoukos T,Skrinar A,Mansbach H,Kakkis E,Mozaffar T

更新日期：2019-04-30 00:00:00

abstract：OBJECTIVE:To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands. METHODS:In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuro...

journal_title：Neurology

authors： Peters MJ,Bakkers M,Merkies IS,Hoeijmakers JG,van Raak EP,Faber CG

更新日期：2013-10-08 00:00:00