Abstract:
:The authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non-arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide changes were more common in NAION patients (p < 0.001). Twelve of these (11 novel) were potentially pathologic, nine of which altered moderately or highly conserved amino acids in the functional domain of the affected protein. Mitochondrial malfunction may be a risk factor for NAION.
journal_name
Neurologyjournal_title
Neurologyauthors
Bosley TM,Abu-Amero KK,Ozand PTdoi
10.1212/01.wnl.0000140696.34117.95subject
Has Abstractpub_date
2004-10-12 00:00:00pages
1305-8issue
7eissn
0028-3878issn
1526-632Xpii
63/7/1305journal_volume
63pub_type
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