Abstract:
BACKGROUND:Many studies have examined the role of APOE genotype in the development of dementia, specifically Alzheimer disease (AD). The APOE epsilon4 allele (APOE4) is a risk factor for both clinical and neuropathologic AD whereas the APOE epsilon2 allele (APOE2) seems to be protective. This would predict, even with advanced age, that APOE2 carriers would be less likely to have dementia and less likely to meet pathologic criteria for AD. METHODS:The first 85 genotyped participants from The 90+ Study to come to autopsy were included. All-cause dementia (using DSM-IV criteria) and AD (using National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria) diagnoses were made by consensus conference using all available information including neuropsychological testing, neurologic examination, and medical records. Neuropathologic examination included Braak and Braak staging for plaques and tangles and diagnosis of neuropathologic AD using National Institute on Aging-Reagan criteria. RESULTS:Across all genotypes, 58.5% of subjects were diagnosed with clinical dementia (81% of dementia was AD) and 50.0% met neuropathologic criteria for AD. Compared to those with an APOE epsilon3/epsilon3 genotype (APOE3/3), APOE4 carriers were more likely to be diagnosed with dementia (odds ratio [OR] = 12.2, 95% confidence interval [CI] = 1.5-102.0), whereas APOE2 carriers were not (OR = 0.3, 95% CI = 0.1-1.3). Surprisingly, both APOE4 (OR = 4.6, 95% CI = 1.3-16.5) and APOE2 (OR = 7.8, 95% CI = 1.5-40.2) carriers were more likely to meet neuropathologic criteria for AD than those with APOE3/3 genotype. CONCLUSIONS:In the oldest old, the presence of the APOE epsilon2 allele (APOE2) was associated with a somewhat reduced risk of dementia, but paradoxically was associated with increased Alzheimer disease (AD) neuropathology. Therefore, oldest old APOE2 carriers may have some mechanism that contributes to the maintenance of cognition independently of the formation of AD pathology.
journal_name
Neurologyjournal_title
Neurologyauthors
Berlau DJ,Corrada MM,Head E,Kawas CHdoi
10.1212/01.wnl.0000343853.00346.a4subject
Has Abstractpub_date
2009-03-03 00:00:00pages
829-34issue
9eissn
0028-3878issn
1526-632Xpii
72/9/829journal_volume
72pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Inhibitory antibody to von Willebrand factor (vWF)-cleaving protease (ADAMTS13) was detected in a patient with intravascular lymphomatosis. The increased serum level of the antibody paralleled an increase in the expression of uncleaved vWF, which might cause microvascular thrombosis and platelet consumption. Malignant...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000143065.55002.67
更新日期:2004-11-09 00:00:00
abstract::The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002219
更新日期:2015-12-15 00:00:00
abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31829c5cfe
更新日期:2013-07-23 00:00:00
abstract::The authors describe a patient with sporadic distal myopathy associated with reduced caveolin-3 in muscle fibers in which the muscle atrophy was restricted to the small muscles of the hands and feet. Gene analysis disclosed a heterozygous 80 G-->A substitution in the caveolin-3 gene that was identical to that of repor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.323
更新日期:2002-01-22 00:00:00
abstract::We developed a rating scale for tic disorders that uses only objective criteria and accommodates the variety of tic manifestations. Using short videotaped recordings with the examiner out of the taping room, we measured five tic variables: number of body areas affected, frequency of motor tics and vocalizations, and s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.9.1542
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To report on the benefits of noninvasive vagus nerve stimulation (nVNS) on acute vestibular migraine (VM) treatment. METHODS:This was a retrospective chart review of patients with VM treated with nVNS in a single tertiary referral center between November 2017 and January 2019. Eighteen patients (16 women) we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008388
更新日期:2019-10-29 00:00:00
abstract::In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.987
更新日期:1995-05-01 00:00:00
abstract::A patient developed an amnesic syndrome after cardiopulmonary arrest. Neuropathologic examination revealed pronounced anoxic injury to both hippocampi with little damage to other hemisphere structures. The clinical and pathologic findings suggest that lesions limited to the hippocampus can cause profound amnesia. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.5.679
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:We investigated if tau, microtubular binding protein, in serum and ventricular CSF (vCSF) in patients with severe traumatic brain injury (TBI) during the initial posttraumatic days correlated to 1-year outcome.
METHODS:Patients with severe TBI (n = 39, Glasgow Coma Scale score journal_title:Neurology pub_type: 杂志文章 doi:10.1212/01.wnl.0000242732.06714.0f 更新日期:2006-11-14 00:00:00
abstract:OBJECTIVE:To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients ≥45 years old. METHOD:Observational cohort study. RESULTS:In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients ≥45 years old. Compared with younger adults (18-44 years), older ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a4a49c
更新日期:2013-09-17 00:00:00
abstract::A 15-year-old girl with a 3-year history of Rasmussen syndrome (RS) underwent left functional hemispherectomy by central disconnection. Clinical seizures then ceased. Five months postoperatively, ictal EEG discharges were associated with focal hyperperfusion on SPECT within the disconnected hypoperfused left hemispher...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.60.1.140
更新日期:2003-01-14 00:00:00
abstract::Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.4.377
更新日期:1981-04-01 00:00:00
abstract::Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.831
更新日期:1984-06-01 00:00:00
abstract::We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.11.2065
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel cor...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000009632
更新日期:2020-06-09 00:00:00
abstract::The excitability of the corticospinal system was studied in 23 healthy subjects in sleep stages NREM2, NREM4, REM, and wakefulness using transcranial magnetic stimulation. Assessment of motor thresholds, stimulus-response curves, and latencies of motor evoked potentials shows activation of the fast-conducting corticos...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000038762.11894.da
更新日期:2002-12-24 00:00:00
abstract:OBJECTIVES:Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS:Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000154
更新日期:2014-02-25 00:00:00
abstract::We conducted an exploratory study of young-onset Parkinson's disease (YOPD) to examine occupational and environmental factors associated with disease risk. This case-control study included 63 YOPD patients (diagnosis on or before age 50); controls (n = 68) were diagnosed with rheumatoid arthritis. Crude odds ratios (O...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.6.1150
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations. METHODS:Data were analyzed from 57,247 patients with acute ischemic stroke receiving IV ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002199
更新日期:2015-12-15 00:00:00
abstract::This study investigates the histories and the clinical course of 111 patients who had nonlesional temporal lobe epilepsy. We compared 61 patients with unilateral hippocampal sclerosis (UHS group) and 50 patients with minimal change (MRI negative group) assessed on the basis of MRI. In agreement with previous reports, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1199
更新日期:1996-11-01 00:00:00
abstract::We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.2045
更新日期:1992-10-01 00:00:00
abstract::Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.46.3.641
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:To analyze the impact of neutralizing antibodies (NAbs) on the clinical efficacy of IFNbeta. METHODS:This was an open-label study involving 78 patients with multiple sclerosis treated with Betaferon 8 million IU (MIU) subcutaneously (SC) every other day (n = 20), Rebif 22 micro g SC 3 times weekly (n = 25), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129265.73259.9e
更新日期:2004-06-08 00:00:00
abstract:OBJECTIVE:In children with sickle cell disease (SCD), silent cerebral infarcts are the most frequent cause of neurologic injury. We determined the sensitivity and specificity of selective neurocognitive measures when separating children with silent cerebral infarcts and SCD from sibling controls. Additionally, we teste...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1678
更新日期:1998-06-01 00:00:00
abstract::Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management is changing the approach to stroke patients. The development process has been difficult and the current treatment recommendations have been controversial. Rece...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.53.1.14
更新日期:1999-07-13 00:00:00
abstract:OBJECTIVES:We hypothesized that integrated motor-visual functions measured by manipulative manual dexterity are affected by white matter lesion (WML) burden as measured on cranial MRI across relevant brain regions in subjects at risk of preclinical occult vascular disease. METHODS:A real-time cross-sectional study of ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000001557
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:There is no generally accepted instrument for measuring quality of life (QOL) in patients with ALS. Current instruments are either too heavily weighted toward strength and physical function or useful for the evaluation of individuals but of less utility in assessing large samples. OBJECTIVE:To develop and e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000242887.79115.19
更新日期:2006-11-14 00:00:00
abstract:OBJECTIVE:To perform a meta-analysis of 4 core CSF biomarkers (β-amyloid [Aβ]42, Aβ40, total tau [t-tau], and phosphorylated tau [p-tau]) to assess which of these are most altered in sporadic cerebral amyloid angiopathy (CAA). METHODS:We systematically searched PubMed for eligible studies reporting data on CSF biomark...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0000000000005030
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Huntington's disease (HD) is a fatal and progressive neurodegenerative disease that is accompanied by involuntary movements, cognitive dysfunction, and psychiatric symptoms. Although progressive striatal degeneration is known to occur, little is known about how the disease affects the cortex, including which...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.695
更新日期:2002-03-12 00:00:00
abstract:OBJECTIVE:Learning and memory impairments are prevalent among persons with multiple sclerosis (MS); however, such deficits are only weakly associated with MS disease severity (brain atrophy). The cognitive reserve hypothesis states that greater lifetime intellectual enrichment lessens the negative impact of brain disea...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e396be
更新日期:2010-06-15 00:00:00