Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury.

Abstract:

OBJECTIVE:We investigated if tau, microtubular binding protein, in serum and ventricular CSF (vCSF) in patients with severe traumatic brain injury (TBI) during the initial posttraumatic days correlated to 1-year outcome. METHODS:Patients with severe TBI (n = 39, Glasgow Coma Scale score 2,126 pg/mL on days 2 to 3 discriminated between dead and alive (sensitivity of 100% and a specificity of 81%). A vCSF total tau level of >702 pg/mL on days 2 to 3 discriminated between bad (GOSE 1 to 4) and good (GOSE 5 to 8) outcome (sensitivity of 83% and a specificity of 69%). Patients with GOSE 1 (dead) had higher vCSF total tau levels on days 2 to 3 (p < 0.001) vs both surviving patients (GOSE 2 to 8) and those with NPH. Total tau was not detected in serum throughout the study. CONCLUSION:The increase in ventricular CSF (vCSF) total tau probably reflects axonal damage, known to be a central pathologic mechanism in traumatic brain injury (TBI). These results suggest that vCSF total tau may be an important early biochemical neuromarker for predicting long-term outcome in patients with a severe TBI.

journal_name

Neurology

journal_title

Neurology

authors

Ost M,Nylén K,Csajbok L,Ohrfelt AO,Tullberg M,Wikkelsö C,Nellgård P,Rosengren L,Blennow K,Nellgård B

doi

10.1212/01.wnl.0000242732.06714.0f

subject

Has Abstract

pub_date

2006-11-14 00:00:00

pages

1600-4

issue

9

eissn

0028-3878

issn

1526-632X

pii

67/9/1600

journal_volume

67

pub_type

杂志文章
  • Is there a link between alertness and fatigue in patients with traumatic brain injury?

    abstract:OBJECTIVES:Many patients with traumatic brain injury (TBI) report chronic fatigue, and previous studies showed a potential relationship between sleepiness and fatigue in these patients. Our study first looked at the impact of objective and subjective sleepiness on fatigue in patients with TBI. We then investigated how ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000334753.49193.48

    authors: Chaumet G,Quera-Salva MA,Macleod A,Hartley S,Taillard J,Sagaspe P,Mazaux JM,Azouvi P,Joseph PA,Guilleminault C,Bioulac B,Léger D,Philip P

    更新日期:2008-11-11 00:00:00

  • Incidence and prevalence of multiple sclerosis in Saskatoon, Saskatchewan.

    abstract:OBJECTIVE:To determine the incidence of multiple sclerosis (MS) in a longitudinal surveillance over 35 years and to estimate the prevalence rate in Saskatoon, Saskatchewan, on January 1, 2005. METHODS:A population-based registry was established in 1969, and identification of cases continued to 2005, from medical recor...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000276991.13764.77

    authors: Hader WJ,Yee IM

    更新日期:2007-09-18 00:00:00

  • Long-lasting conduction block in hereditary neuropathy with liability to pressure palsies.

    abstract::We detected 29 conduction blocks in 12 patients with hereditary neuropathy and liability to pressure palsies. The blocks occurred at entrapment sites, most often the ulnar nerve at the elbow. Some had lasted for several years. This kind of block seems to be characteristic of the neuropathy, and may be related to the l...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.11.1639

    authors: Magistris MR,Roth G

    更新日期:1985-11-01 00:00:00

  • LGI1 mutations in temporal lobe epilepsies.

    abstract:BACKGROUND AND OBJECTIVES:A number of familial temporal lobe epilepsies (TLE) have been recently recognized. Mutations in LGI1 (leucine-rich, glioma-inactivated 1 gene) have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF). The authors aimed to determ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000118213.94650.81

    authors: Berkovic SF,Izzillo P,McMahon JM,Harkin LA,McIntosh AM,Phillips HA,Briellmann RS,Wallace RH,Mazarib A,Neufeld MY,Korczyn AD,Scheffer IE,Mulley JC

    更新日期:2004-04-13 00:00:00

  • Primary cervical dystonia and scoliosis: a multicenter case-control study.

    abstract:OBJECTIVE:To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects. METHODS:Case and control subjects were selected among consecutive outpatients attending four Italian centers. Control outpatients were matched for age (+/-5 years), sex, a...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/01.wnl.0000049932.22065.60

    authors: Defazio G,Abbruzzese G,Girlanda P,Buccafusca M,Currà A,Marchese R,Martino D,Masi G,Mazzella L,Vacca L,Livrea P,Berardelli A

    更新日期:2003-03-25 00:00:00

  • Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.

    abstract:OBJECTIVE:To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations. METHODS:All exons of the CHCHD2 gene were sequenced in a US Caucasian patient-control series (878 PD, 610 LBD, and 717 controls). Subsequently, exons 1 and 2 were sequenced in a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002170

    authors: Ogaki K,Koga S,Heckman MG,Fiesel FC,Ando M,Labbé C,Lorenzo-Betancor O,Moussaud-Lamodière EL,Soto-Ortolaza AI,Walton RL,Strongosky AJ,Uitti RJ,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska

    更新日期:2015-12-08 00:00:00

  • Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy.

    abstract:BACKGROUND:The best treatment for polyneuropathy associated with IgM monoclonal gammopathy (MGUS) is unknown. Oral cyclophosphamide combined with prednisone showed limited efficacy in a previous open label pilot study. We therefore performed a double-blind, randomized, placebo-controlled study of combined oral cyclopho...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000265055.28218.cc

    authors: Niermeijer JM,Eurelings M,van der Linden MW,Lokhorst HM,Franssen H,Fischer K,Teunissen LL,van den Berg LH,Schobben F,Wokke JH,Notermans NC

    更新日期:2007-07-03 00:00:00

  • Hypnic headache: clinical features, pathophysiology, and treatment.

    abstract::Hypnic headache has been described in several case reports since 1981 and is regarded as an idiopathic headache disorder. In this review of 71 cases in the literature, the clinical features, neurophysiologic including polysomnographic findings, and treatment procedures are analyzed and the pathophysiology of this cond...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000046582.21771.9c

    authors: Evers S,Goadsby PJ

    更新日期:2003-03-25 00:00:00

  • Local alterations of hemostatic-fibrinolytic mechanisms in reforming subdural hematomas.

    abstract::Multiple chemical and coagulation determinations were undertaken on the subdural hematoma fluid from the reformed effusions of two patients. It was found that plasma or blood repeatedly reentered the subdural cavity. Coagulation studies compared the in vitro effects of subdural fluid with those of cerebrospinal fluid,...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.25.7.669

    authors: Labadie EL,Glover D

    更新日期:1975-07-01 00:00:00

  • Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...

    journal_title:Neurology

    pub_type: 杂志文章,实务指引

    doi:10.1212/01.wnl.0000215428.46057.3d

    authors: Miyasaki JM,Shannon K,Voon V,Ravina B,Kleiner-Fisman G,Anderson K,Shulman LM,Gronseth G,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

    更新日期:2006-04-11 00:00:00

  • Experimental CNS ischemia: serotonin antagonists reduce or prevent damage.

    abstract::We tested three serotonin antagonists--lysergic acid diethylamide (LSD), 2-bromolysergic acid diethylamide (BOL), and cinanserin--for effects on experimental spinal cord ischemia in the rabbit. Blood flow to spinal cord was obstructed. Drugs were administered before or after initiation of occlusion, and flow was later...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.4.469

    authors: Zivin JA,Venditto JA

    更新日期:1984-04-01 00:00:00

  • Airborne rabies encephalitis: demonstration of rabies virus in the human central nervous system.

    abstract::A veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. Identification, isol...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.1.67

    authors: Conomy JP,Leibovitz A,McCombs W,Stinson J

    更新日期:1977-01-01 00:00:00

  • Mutations in GABRB3: From febrile seizures to epileptic encephalopathies.

    abstract:OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003565

    authors: Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

    更新日期:2017-01-31 00:00:00

  • Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test.

    abstract::To determine if there is abnormal phenylalanine and biopterin metabolism in patients with dopa-responsive dystonia (DRD), we measured plasma levels of phenylalanine, tyrosine, biopterin, and neopterin at baseline, and 1, 2, 4, and 6 hours after an oral phenylalanine load (100 mg/kg). Seven adults with DRD, two severel...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.5.1290

    authors: Hyland K,Fryburg JS,Wilson WG,Bebin EM,Arnold LA,Gunasekera RS,Jacobson RD,Rost-Ruffner E,Trugman JM

    更新日期:1997-05-01 00:00:00

  • Focal Alzheimer's disease.

    abstract::Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.1.14

    authors: Jagust WJ,Davies P,Tiller-Borcich JK,Reed BR

    更新日期:1990-01-01 00:00:00

  • A case-control and nerve biopsy study of CREST multiple mononeuropathy.

    abstract::From 536 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis), seven were identified as having peripheral neuropathy not attributable to another cause. Peripheral neuropathy developed 0 to 25 years after their first symptoms of scleroderma. Unex...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.6.1641

    authors: Dyck PJ,Hunder GG,Dyck PJ

    更新日期:1997-12-01 00:00:00

  • Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies.

    abstract::The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.2.321

    authors: Diav-Citrin O,Shechtman S,Arnon J,Ornoy A

    更新日期:2001-07-24 00:00:00

  • New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.

    abstract:OBJECTIVE:To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. METHODS:Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. D...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31827e07be

    authors: Hogarth P,Gregory A,Kruer MC,Sanford L,Wagoner W,Natowicz MR,Egel RT,Subramony SH,Goldman JG,Berry-Kravis E,Foulds NC,Hammans SR,Desguerre I,Rodriguez D,Wilson C,Diedrich A,Green S,Tran H,Reese L,Woltjer RL,Hayfli

    更新日期:2013-01-15 00:00:00

  • The minor symptoms of increased intracranial pressure: 101 patients with benign intracranial hypertension.

    abstract::Of 101 patients with benign intracranial hypertension not related to vasculitis, neck stiffness occurred in 31, tinnitus in 27, distal extremity paresthesias in 22, joint pains in 13, low back pain in 5, and gait "ataxia" in 4. Symptoms resolved promptly upon lowering the intracranial pressure by lumbar puncture, and ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.9.1461

    authors: Round R,Keane JR

    更新日期:1988-09-01 00:00:00

  • The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1.

    abstract::Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000240076.31298.47

    authors: Leonard JR,Perry A,Rubin JB,King AA,Chicoine MR,Gutmann DH

    更新日期:2006-10-24 00:00:00

  • Long-term cerebral white and gray matter changes after preeclampsia.

    abstract:OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003765

    authors: Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

    更新日期:2017-03-28 00:00:00

  • Comment on 2018 American Academy of Neurology guidelines on disease-modifying therapies in MS.

    abstract::The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000005574

    authors: Corboy JR,Weinshenker BG,Wingerchuk DM

    更新日期:2018-06-12 00:00:00

  • Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus.

    abstract::The disease locus for the clinically heterogeneous childhood spinal muscular atrophies (SMA) maps to the chromosome 5 subregion, 5q11.2-13.3. The beta-subunit of beta-D-N-acetylhexosaminidase (hexosaminidase) (EC 3.2.1.52) (Hex B) maps to the same region, and the protein required for substrate recognition by this enzy...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.9.1418

    authors: Kleyn PW,Brzustowicz LM,Wilhelmsen KC,Freimer NB,Miller JM,Munsat TL,Gilliam TC

    更新日期:1991-09-01 00:00:00

  • Current treatments of epilepsy.

    abstract::Medical therapy is the mainstay for epilepsy, with most patients well controlled on a single antiepileptic drug (AED). In this non-refractory group, many patients have medication side effects and occasional seizures. Approximately 30% of patients with partial epilepsy and 25% of patients with generalized epilepsy are ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.64.12_suppl_3.s2

    authors: Nadkarni S,LaJoie J,Devinsky O

    更新日期:2005-06-28 00:00:00

  • Demonstration of CSF gamma-globulin banding in presenile dementia.

    abstract::An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.8.882

    authors: Williams A,Papadopoulos N,Chase TN

    更新日期:1980-08-01 00:00:00

  • Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

    abstract::Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the path...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000204225.15947.f8

    authors: Sprenger T,Willoch F,Miederer M,Schindler F,Valet M,Berthele A,Spilker ME,Förderreuther S,Straube A,Stangier I,Wester HJ,Tölle TR

    更新日期:2006-04-11 00:00:00

  • HLA B*44: protective effects in MS susceptibility and MRI outcome measures.

    abstract:OBJECTIVE:In addition to the main multiple sclerosis (MS) major histocompatibility complex (MHC) risk allele (HLA DRB1*1501), investigations of the MHC have implicated several class I MHC loci (HLA A, HLA B, and HLA C) as potential independent MS susceptibility loci. Here, we evaluate the role of 3 putative protective ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181ed9c9c

    authors: Healy BC,Liguori M,Tran D,Chitnis T,Glanz B,Wolfish C,Gauthier S,Buckle G,Houtchens M,Stazzone L,Khoury S,Hartzmann R,Fernandez-Vina M,Hafler DA,Weiner HL,Guttmann CR,De Jager PL

    更新日期:2010-08-17 00:00:00

  • Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection.

    abstract::Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subac...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.4.562

    authors: de la Monte SM,Ho DD,Schooley RT,Hirsch MS,Richardson EP Jr

    更新日期:1987-04-01 00:00:00

  • Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures. The M88-194 Study Group.

    abstract::We studied the efficacy of divalproex sodium in patients with complex partial seizures taking concomitant carbamazepine or phenytoin as monotherapy. Patients were selected because of inadequate seizure control by current therapy. The primary efficacy measure was median reduction of seizure frequency during add-on trea...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.46.1.49

    authors: Willmore LJ,Shu V,Wallin B

    更新日期:1996-01-01 00:00:00

  • Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy.

    abstract:OBJECTIVE:To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm. METHODS:The authors performed a retrospective evaluation of patient data obtained during presurgical evaluation, with additional CSF analyses, serum analyses, and histopathologic investigations. RESULTS:The...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.12.1823

    authors: Bien CG,Schulze-Bonhage A,Deckert M,Urbach H,Helmstaedter C,Grunwald T,Schaller C,Elger CE

    更新日期:2000-12-26 00:00:00