Abstract:
:Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS from unrelated SOD1-negative familial ALS families. These observations provide further evidence that PLS can be linked pathophysiologically to ALS.
journal_name
Neurologyjournal_title
Neurologyauthors
Brugman F,Wokke JH,Vianney de Jong JM,Franssen H,Faber CG,Van den Berg LHdoi
10.1212/01.WNL.0000162033.47893.F7subject
Has Abstractpub_date
2005-05-24 00:00:00pages
1778-9issue
10eissn
0028-3878issn
1526-632Xpii
64/10/1778journal_volume
64pub_type
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