Current treatment pathways in ALS: a European perspective.

abstract：BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

journal_title：Neurology

authors： Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

更新日期：2005-12-13 00:00:00

abstract：:Between 1982 and 1989, 197 patients with Parkinson's disease were treated with selegiline and levodopa for at least 0.3 years. Two groups of patients were included: a group of 65 patients (stage 2 or 3 on the Hoehn and Yahr Scale) who recently had been started on levodopa and were not experiencing response fluctuation...

journal_title：Neurology

authors： Lieberman A

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...

journal_title：Neurology

authors： Wiegertjes K,Ter Telgte A,Oliveira PB,van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Klijn CJM,Tuladhar AM,de Leeuw FE

更新日期：2019-10-22 00:00:00

abstract：:Phenytoin suspension (PHY-S) is reported to settle, resulting in uneven drug distribution and variable patient dosing. We designed this study to determine the rate of settling and the amount of agitation needed to resuspend the preparation. To determine the rate of settling, we thoroughly shook three bottles of PHY-S ...

journal_title：Neurology

authors： Sarkar MA,Garnett WR,Karnes HT

更新日期：1989-02-01 00:00:00

abstract：:Fatigue is a common but poorly understood symptom in Parkinson's disease (PD). Using previously validated scales, we asked 58 nondemented PD patients and 58 controls to fill out questionnaires assessing fatigue and depression and found that PD patients were more depressed and more fatigued than age-matched controls. A...

journal_title：Neurology

authors： Friedman J,Friedman H

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...

journal_title：Neurology

authors： Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

更新日期：2003-12-09 00:00:00

abstract：OBJECTIVE:To study prevalence of and factors contributing to burnout, career satisfaction, and well-being in US neurology residents and fellows. METHODS:A total of 938 US American Academy of Neurology member neurology residents and fellows were surveyed using standardized measures of burnout, career satisfaction, and ...

journal_title：Neurology

authors： Levin KH,Shanafelt TD,Keran CM,Busis NA,Foster LA,Molano JRV,O'Donovan CA,Ratliff JB,Schwarz HB,Sloan JA,Cascino TL

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To determine the incidence of first seizures, epilepsy, and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition, which allows an epilepsy diagnosis after a single seizure when the risk of further seizures over the next 10 years is ≈60%...

journal_title：Neurology

authors： Maloney EM,Chaila E,O'Reilly ÉJ,Costello DJ

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVE:To test efficacy and safety of atorvastatin in subjects with clinically isolated syndrome (CIS). METHODS:Subjects with CIS were enrolled in a phase II, double-blind, placebo-controlled, 14-center randomized trial testing 80 mg atorvastatin on clinical and brain MRI activity. Brain MRIs were performed quarter...

journal_title：Neurology

authors： Waubant E,Pelletier D,Mass M,Cohen JA,Kita M,Cross A,Bar-Or A,Vollmer T,Racke M,Stüve O,Schwid S,Goodman A,Kachuck N,Preiningerova J,Weinstock-Guttman B,Calabresi PA,Miller A,Mokhtarani M,Iklé D,Murphy S,Kopetskie

更新日期：2012-04-10 00:00:00

abstract：OBJECTIVE:In the North Dublin Population Stroke Study, we investigated the risk of recurrent stroke within the 14-day time window recommended for endarterectomy. METHODS:In a population-based prospective cohort study, all ischemic stroke patients were identified over 1 year and categorized into those with (CS-positive...

journal_title：Neurology

authors： Marnane M,Ni Chroinin D,Callaly E,Sheehan OC,Merwick A,Hannon N,Horgan G,Kyne L,Moroney J,McCormack PM,Dolan E,Duggan J,Williams D,Crispino-O'Connell G,Kelly PJ

更新日期：2011-08-23 00:00:00

abstract：:Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months' duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44 (29%); breast carcinoma, 10/51 (20%); a...

journal_title：Neurology

authors： Siegal T,Lossos A,Pfeffer MR

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS:We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for i...

journal_title：Neurology

authors： Albright KC,Huang L,Blackburn J,Howard G,Mullen M,Bittner V,Muntner P,Howard V

更新日期：2018-11-06 00:00:00

abstract：OBJECTIVE:There is a high risk of readmission within 30 days of index acute ischemic stroke (AIS), but effect of readmission to a different hospital is not known. We performed a retrospective cohort study to assess our hypothesis that 30-day readmission outcomes after AIS are worse for those readmitted to another hospi...

journal_title：Neurology

authors： Stein LK,Agarwal P,Thaler A,Kwon CS,Jette N,Dhamoon MS

更新日期：2019-11-12 00:00:00

abstract：OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...

journal_title：Neurology

authors： Huang W,Alexander GE,Chang L,Shetty HU,Krasuski JS,Rapoport SI,Schapiro MB

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM). A wave V latency prolongation of 1.0 milliseconds or amplitude decrement of greater than 50% is arbitrarily considered the point when...

journal_title：Neurology

authors： James ML,Husain AM

更新日期：2005-11-22 00:00:00

abstract：:Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...

journal_title：Neurology

authors： Rinker JR 2nd,Trinkaus K,Cross AH

更新日期：2006-10-10 00:00:00

abstract：BACKGROUND:Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and famili...

journal_title：Neurology

authors： Burwick RM,Ramsay PP,Haines JL,Hauser SL,Oksenberg JR,Pericak-Vance MA,Schmidt S,Compston A,Sawcer S,Cittadella R,Savettieri G,Quattrone A,Polman CH,Uitdehaag BM,Zwemmer JN,Hawkins CP,Ollier WE,Weatherby S,Enzinger C

更新日期：2006-05-09 00:00:00

abstract：OBJECTIVE:Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. METHODS:Investigators f...

journal_title：Neurology

authors： Sharma M,Ioannidis JP,Aasly JO,Annesi G,Brice A,Van Broeckhoven C,Bertram L,Bozi M,Crosiers D,Clarke C,Facheris M,Farrer M,Garraux G,Gispert S,Auburger G,Vilariño-Güell C,Hadjigeorgiou GM,Hicks AA,Hattori N,Jeon B,

更新日期：2012-08-14 00:00:00

abstract：:The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum...

journal_title：Neurology

authors： Bollensen E,Steck AJ,Schachner M

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...

journal_title：Neurology

authors： Röricht S,Meyer BU

更新日期：2000-02-22 00:00:00

abstract：:We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...

journal_title：Neurology

authors： Leis AA,Ross MA,Summers AK

更新日期：1992-01-01 00:00:00

abstract：:Several drugs that inhibit the effects of serotonin may reduce or prevent experimental CNS ischemic damage, but these drugs are not approved for human use in the United States. Administration of cyproheptadine (which is available for clinical use) 15 minutes before or 5 minutes after the onset increased the duration o...

journal_title：Neurology

authors： Zivin JA

更新日期：1985-04-01 00:00:00

abstract：:Glucocorticoid therapy slows the progression of Duchenne muscular dystrophy. In muscle cultures, the addition of the glucocorticoid methylprednisolone increases myogenesis in most normal mixed and clonal cultures. Conversely, in some normal clonal and most dystrophic cultures, methylprednisolone inhibits fusion. Howev...

journal_title：Neurology

authors： Hardiman O,Sklar RM,Brown RH Jr

更新日期：1993-02-01 00:00:00

abstract：:Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...

journal_title：Neurology

authors： Snead OC 3rd,Yu RK,Huttenlocher PR

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:To identify the genetic and physiologic basis for recessive myasthenic congenital myopathy in 2 families, suggestive of a channelopathy involving the sodium channel gene, SCN4A. METHODS:A combination of whole exome sequencing and targeted mutation analysis, followed by voltage-clamp studies of mutant sodium ...

journal_title：Neurology

authors： Elia N,Palmio J,Castañeda MS,Shieh PB,Quinonez M,Suominen T,Hanna MG,Männikkö R,Udd B,Cannon SC

更新日期：2019-03-26 00:00:00

abstract：OBJECTIVE:The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society develop practice parameters as strategies for patient management based on analysis of evidence. For this parameter, the authors reviewed available evidence on the evaluation of the...

journal_title：Neurology

authors： Lewis DW,Ashwal S,Dahl G,Dorbad D,Hirtz D,Prensky A,Jarjour I,Quality Standards Subcommittee of the American Academy of Neurology.,Practice Committee of the Child Neurology Society.

更新日期：2002-08-27 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To perform whole-brain morphometry in patients with frontal lobe epilepsy and evaluate the utility of group-level patterns for individualized diagnosis and prognosis. METHODS:We compared MRI-based cortical thickness and folding complexity between 2 frontal lobe epilepsy cohorts with histologically verified f...

journal_title：Neurology

authors： Hong SJ,Bernhardt BC,Schrader DS,Bernasconi N,Bernasconi A

更新日期：2016-02-16 00:00:00

abstract：:Subarachnoid neurolysis using ethanol to destroy selectively the posterior roots of the spinal cord is a method for providing pain relief in patients with advanced cancer. Weakness of the extremities is a complication of the procedure that has been attributed to spread of the neurolytic agent to the anterior roots. Th...

journal_title：Neurology

authors： McGarvey ML,Ferrante FM,Patel RS,Maljian JA,Stecker M

更新日期：2000-04-11 00:00:00

abstract：OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...

journal_title：Neurology

authors： Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

更新日期：2012-11-13 00:00:00