Demonstration of CSF gamma-globulin banding in presenile dementia.


:An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients.






Williams A,Papadopoulos N,Chase TN




Has Abstract


1980-08-01 00:00:00












  • Comparison of depth and subdural electrodes in recording temporal lobe seizures.

    abstract::Intracranial EEG recording is often required to identify an area of the brain for resective surgery for intractable epilepsy. We simultaneously compared bilaterally placed depth and limited subdural electrode EEG to determine the most effective method of recording seizures from the temporal lobes. Localized complex pa...


    pub_type: 杂志文章


    authors: Sperling MR,O'Connor MJ

    更新日期:1989-11-01 00:00:00

  • Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution.

    abstract::Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Maintenance doses of 3 to 4 mg per kilogram of both agents will maintain therapeutic levels. Phenytoin is, however, not pred...


    pub_type: 杂志文章


    authors: Painter MJ,Pippenger C,Wasterlain C,Barmada M,Pitlick W,Carter G,Abern S

    更新日期:1981-09-01 00:00:00

  • Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

    abstract::Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilo...


    pub_type: 杂志文章


    authors: Barboriak DP,Doraiswamy PM,Krishnan KR,Vidyarthi S,Sylvester J,Charles HC

    更新日期:2000-06-13 00:00:00

  • Hypnic headache: clinical features, pathophysiology, and treatment.

    abstract::Hypnic headache has been described in several case reports since 1981 and is regarded as an idiopathic headache disorder. In this review of 71 cases in the literature, the clinical features, neurophysiologic including polysomnographic findings, and treatment procedures are analyzed and the pathophysiology of this cond...


    pub_type: 杂志文章,评审


    authors: Evers S,Goadsby PJ

    更新日期:2003-03-25 00:00:00

  • Exploratory saccades show no direction-specific deficit in neglect.

    abstract::In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...


    pub_type: 杂志文章


    authors: Niemeier M,Karnath HO

    更新日期:2000-01-25 00:00:00

  • Effect of comorbidity on mortality in multiple sclerosis.

    abstract:OBJECTIVE:We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS:Using population-based administrative data, we identified 5,797 persons with MS and 28,807 contro...


    pub_type: 杂志文章


    authors: Marrie RA,Elliott L,Marriott J,Cossoy M,Blanchard J,Leung S,Yu N

    更新日期:2015-07-21 00:00:00

  • Pharmacologic treatment and evaluation of permanent experimental spinal cord trauma.

    abstract::Permanent paralysis was induced in dogs by a 500 gram centimeter force injury on the spinal cord, and drug treatments were given 1 hour after injury and were continued for 3 days. Dogs were evaluated for 90 days. Isotonic saline or mannitol administration were ineffective in reversing the paralysis. In dogs receiving ...


    pub_type: 杂志文章


    authors: De La Torre JC,Johnson CM,Goode DJ,Mullan S

    更新日期:1975-06-01 00:00:00

  • A family with Machado-Joseph disease, previously diagnosed as dentatorubral-pallidoluysian atrophy.

    abstract::We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...


    pub_type: 杂志文章


    authors: Sakai T,Antoku Y,Kawakami H,Maruyama H,Nakamura S,Tanaka K

    更新日期:1996-04-01 00:00:00

  • Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes.

    abstract:OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...


    pub_type: 杂志文章


    authors: Orkaby AR,Cho K,Cormack J,Gagnon DR,Driver JA

    更新日期:2017-10-31 00:00:00

  • Mechanisms of action of anticonvulsant agents.

    abstract::Systematic screening of many compounds in animal models led to identification of the established antiepileptic drugs (AEDs). By contrast, the newer AEDs were specifically designed to enhance an inhibitory process or to inhibit a specific excitatory pathway. However, it was later discovered that some of the designed dr...


    pub_type: 杂志文章,评审


    authors: Moshé SL

    更新日期:2000-01-01 00:00:00

  • A double mutation (A8296G and G8363A) in the mitochondrial DNA tRNA (Lys) gene associated with myoclonus epilepsy with ragged-red fibers.

    abstract:OBJECTIVE:To define potential pathogenic mitochondrial DNA (mtDNA) point mutations in a patient with myoclonus epilepsy with ragged-red fibers (MERRF) syndrome. BACKGROUND:MERRF syndrome is typically associated with point mutations in the mtDNA tRNALys gene. METHODS:We performed morphologic, biochemical, and genetic ...


    pub_type: 杂志文章


    authors: Arenas J,Campos Y,Bornstein B,Ribacoba R,Martín MA,Rubio JC,Santorelli FM,Zeviani M,DiMauro S,Garesse R

    更新日期:1999-01-15 00:00:00

  • Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study.

    abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...


    pub_type: 杂志文章


    authors: Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

    更新日期:2012-11-13 00:00:00

  • Cerebral vasocapacitance and TIAs.

    abstract::We report the vasocapacitance of the cerebral circulation, as determined by cerebral blood flow reactivity to induced hypercapnia using fluoromethane positron emission tomography, in 32 patients with unilateral anterior circulation transient ischemic attacks. A hemodynamic subset of eight patients, defined based on ex...


    pub_type: 杂志文章


    authors: Levine RL,Lagreze HL,Dobkin JA,Hanson JM,Satter MR,Rowe BR,Nickles RJ

    更新日期:1989-01-01 00:00:00

  • A prospective study of predictors of poststroke depression.

    abstract:OBJECTIVE:To investigate the association between early depressive behavior after stroke onset and occurrence of poststroke depression (PSD) at 3- and 12-month follow-up evaluations. METHODS:The study prospectively included 273 patients with first-ever single uncomplicated ischemic stroke. In the stroke unit, nurses sc...


    pub_type: 杂志文章


    authors: Carota A,Berney A,Aybek S,Iaria G,Staub F,Ghika-Schmid F,Annable L,Guex P,Bogousslavsky J

    更新日期:2005-02-08 00:00:00

  • Restless legs syndrome: a predictor of lower physical function.

    abstract::Restless legs syndrome (RLS) is characterized by an urge to move the legs. The symptoms are more intense in the evening and during periods of inactivity. RLS symptoms are relieved by movement. It is classified as a sleep disorder, but in many ways it is actually a disorder of wakefulness that seems to intrude upon the...


    pub_type: 评论,社论


    authors: Auerbach S,Walters AS

    更新日期:2014-04-08 00:00:00

  • Glucose levels and outcome after subarachnoid hemorrhage.

    abstract::In a cohort of 337 patients with subarachnoid hemorrhage (SAH), we investigated the relationship between blood glucose levels, baseline characteristics, and outcome by means of Student's t-test and multivariate logistic regression. The mean glucose levels on admission and from day 1 to 10 were significantly higher in ...


    pub_type: 杂志文章


    authors: Dorhout Mees SM,van Dijk GW,Algra A,Kempink DR,Rinkel GJ

    更新日期:2003-10-28 00:00:00

  • Gustatory agnosia.

    abstract:OBJECTIVE:To report the assessment of a patient exhibiting gustatory agnosia. METHODS:Preoperative and postoperative neuropsychological, neuroimaging, and chemosensory evaluations were performed in a 39-year-old woman undergoing surgical treatment for intractable epilepsy. RESULTS:Preoperative MRIs showed bilateral (...


    pub_type: 杂志文章


    authors: Small DM,Bernasconi N,Bernasconi A,Sziklas V,Jones-Gotman M

    更新日期:2005-01-25 00:00:00

  • Natalizumab reduces visual loss in patients with relapsing multiple sclerosis.

    abstract:OBJECTIVE:To examine the effects of natalizumab on low-contrast letter acuity as a prespecified tertiary endpoint in two randomized clinical trials and to evaluate the usefulness of low-contrast letter acuity testing as a candidate test of visual function in multiple sclerosis (MS). METHODS:AFFIRM and SENTINEL were ra...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Balcer LJ,Galetta SL,Calabresi PA,Confavreux C,Giovannoni G,Havrdova E,Hutchinson M,Kappos L,Lublin FD,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Wajgt A,Weinstock-Guttman B,Wynn DR,Lyn

    更新日期:2007-04-17 00:00:00

  • Longitudinal ocular motor study in corticobasal degeneration and progressive supranuclear palsy.

    abstract:OBJECTIVE:To evaluate the usefulness of ocular motor information in the early diagnosis of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). METHODS:Seven PSP patients, six CBD patients, and three atypical CBD patients were followed longitudinally with repeated electrooculographic (EOG) recordi...


    pub_type: 杂志文章


    authors: Rivaud-Péchoux S,Vidailhet M,Gallouedec G,Litvan I,Gaymard B,Pierrot-Deseilligny C

    更新日期:2000-03-14 00:00:00

  • Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

    abstract::Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the path...


    pub_type: 杂志文章


    authors: Sprenger T,Willoch F,Miederer M,Schindler F,Valet M,Berthele A,Spilker ME,Förderreuther S,Straube A,Stangier I,Wester HJ,Tölle TR

    更新日期:2006-04-11 00:00:00

  • Subcortical degeneration in Alzheimer's disease.

    abstract::Although Alzheimer's disease is generally considered a degenerative disease that primarily affects the cerebral cortex, subcortical structures such as the substantia innominata and certain brainstem nuclei may be involved. In 28 patients with progressive dementia and pathologically confirmed Alzheimer's disease, we fo...


    pub_type: 杂志文章


    authors: McDuff T,Sumi SM

    更新日期:1985-01-01 00:00:00

  • A Wallerian degeneration pattern in patients at risk for MS.

    abstract:BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...


    pub_type: 杂志文章


    authors: Simon JH,Kinkel RP,Jacobs L,Bub L,Simonian N

    更新日期:2000-03-14 00:00:00

  • The role of small diffusion-weighted imaging lesions in cerebral small vessel disease.

    abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...


    pub_type: 杂志文章


    authors: Wiegertjes K,Ter Telgte A,Oliveira PB,van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Klijn CJM,Tuladhar AM,de Leeuw FE

    更新日期:2019-10-22 00:00:00

  • Oral contraceptives and stroke in young women: a clinicopathologic correlation.

    abstract::Pathologic studies of women with fatal cerebrovascular disease who have received oral contraceptives are infrequently found in the literature. Three cases of this type are reported here. The pathologic findings included an intrinsic vascular lesion in the form of intimal hyperplasia with and without associated thrombo...


    pub_type: 杂志文章


    authors: Irey NS,McAllister HA,Henry JM

    更新日期:1978-12-01 00:00:00

  • Homonymous hemianopias: clinical-anatomic correlations in 904 cases.

    abstract:OBJECTIVE:To describe the clinical characteristics and clinical-anatomic correlations of homonymous hemianopia (HH). BACKGROUND:Homonymous hemianopia impairs visual function and frequently precludes driving. Most knowledge of HH is based on relatively few cases with clinical-anatomic correlations. METHODS:The authors...


    pub_type: 杂志文章


    authors: Zhang X,Kedar S,Lynn MJ,Newman NJ,Biousse V

    更新日期:2006-03-28 00:00:00

  • Initiating treatment for idiopathic parkinsonism.

    abstract::The initial decision in the management of idiopathic parkinsonism is whether any pharmacotherapy is indicated. There is no conclusive evidence that treatment is helpful before symptoms start to affect the patient's life, although some neurologists believe that deprenyl, also known as selegiline, could be useful. Once ...


    pub_type: 杂志文章,评审


    authors: Calne DB

    更新日期:1994-07-01 00:00:00

  • Earlier is better: the benefits of early diagnosis.

    abstract::The concept of earlier diagnosis of amyotrophic lateral sclerosis (ALS) requires in-depth investigation of its benefits and consequences. First, how good must a treatment be before ALS is determined to be a treatable condition? Analogy with cancer therapy suggests that a good quality of life after treatment is an esse...


    pub_type: 杂志文章,评审


    authors: Brooks BR

    更新日期:1999-01-01 00:00:00

  • Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures.

    abstract::Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...


    pub_type: 杂志文章


    authors: Friedman D,French JA

    更新日期:2006-02-28 00:00:00

  • Not paralysis, but dystonia causes stridor in multiple system atrophy.

    abstract::Electromyography (EMG) was performed in 10 patients with multiple system atrophy, laryngeal or pharyngeal symptoms, or both. In patients with stridor, EMG during quiet breathing revealed persistent tonic activity in both abductor and adductor vocal cord muscles. In patients with dysphagia, the cricopharyngeal muscle s...


    pub_type: 杂志文章


    authors: Merlo IM,Occhini A,Pacchetti C,Alfonsi E

    更新日期:2002-02-26 00:00:00

  • Double-blind comparison of pramipexole and bromocriptine treatment with placebo in advanced Parkinson's disease. International Pramipexole-Bromocriptine Study Group.

    abstract::Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Guttman M

    更新日期:1997-10-01 00:00:00