Abstract:
BACKGROUND:Elevated serum retinol, CSF retinol, and serum retinol binding protein (RBP) levels have been found in some patients with idiopathic intracranial hypertension (IIH), but serum and CSF retinol levels have not been studied in matched serum and CSF samples in patients with IIH. OBJECTIVE:To determine whether serum and CSF vitamin A concentrations are associated with IIH. METHODS:The serum and CSF retinol concentrations were prospectively assessed in 20 patients with IIH and 20 control subjects. RESULTS:CSF retinol concentration was higher in the patient group (median 575.91 nM) vs the control group (median 63.35 nM) (p < 0.05). There was no difference in serum retinol levels between control subjects (median 896.51 nM) and patients (median 1,002.62 nM) (p = 0.10). There was an association between higher vitamin A levels (> 250 nM) and IIH (p = 0.039). There was a correlation between CSF and serum retinol levels in patients (r = 0.82) and control subjects (r = 0.66). CONCLUSION:Elevated CSF retinol concentration is associated with idiopathic intracranial hypertension (IIH), but serum retinol level is not associated with IIH.
journal_name
Neurologyjournal_title
Neurologyauthors
Tabassi A,Salmasi AH,Jalali Mdoi
10.1212/01.WNL.0000163556.31080.98subject
Has Abstractpub_date
2005-06-14 00:00:00pages
1893-6issue
11eissn
0028-3878issn
1526-632Xpii
64/11/1893journal_volume
64pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare disorder characterized by episodic hyperkinetic movement attacks. We have recently identified mutations in the MR-1 gene causing familial PNKD. METHODS:We reviewed the clinical features of 14 kindreds with familial dyskinesia that was not clearly induced...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000262029.91552.e0
更新日期:2007-05-22 00:00:00
abstract::Significant evidence has accrued suggesting that antibodies to voltage-gated calcium channel are observed in at least some patients with sporadic ALS (SALS) and that such antibodies alter the function of these ion channels in vitro and in vivo. Further, passive transfer of these immunoglobulin-containing fractions int...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.47.4_suppl_2.40s
更新日期:1996-10-01 00:00:00
abstract::In a series of 100 patients exhibiting clinical and molecular features of facioscapulohumeral muscular dystrophy (FSHMD), five patients had conduction defects or arrhythmia in the absence of cardiovascular risk factors--namely, intraventricular conduction delay and supraventricular arrhythmia induced by electrophysiol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.5.1454
更新日期:1998-11-01 00:00:00
abstract::We examined six patients with an abrupt change in behavior after infarction involving the inferior genu of the internal capsule. The acute syndrome featured fluctuating alertness, inattention, memory loss, apathy, abulia, and psychomotor retardation, suggesting frontal lobe dysfunction. Contralateral hemiparesis and d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1966
更新日期:1992-10-01 00:00:00
abstract::To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000250331.35912.a5
更新日期:2007-01-09 00:00:00
abstract::HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in the Caribbean basin and Japan. Because of the close proximity of the United States to the Caribbean and the presence of HTLV-I-seropositive persons in the United States, we sought reports of patients who were HTLV-I seropositive and had ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1355
更新日期:1991-09-01 00:00:00
abstract::We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1593
更新日期:1991-10-01 00:00:00
abstract::Central nervous system disorders may cause obstructive sleep apnea, but this sleep-related breathing disorder is rarely associated with a structural abnormality of the medulla. We present a patient with obstructive apnea resulting from autopsy-proven syringobulbia-myelia. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.8.1046
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:Histologic studies show that the amygdala is affected by Alzheimer disease (AD) pathology, and its medial aspect is the most involved. We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI. METHODS:A total of 19 patients with AD (mean age 76, SD 6 ye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820d62d9
更新日期:2011-02-22 00:00:00
abstract:OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000123260.61631.c4
更新日期:2004-05-11 00:00:00
abstract:OBJECTIVE:Frontotemporal lobar degeneration (FTLD) encompasses a variety of clinicopathologic entities. The antemortem prediction of the underlying pathologic lesions is reputed to be difficult. This study sought to characterize correlations between 1) the different clinical variants of primary progressive language and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c7198e
更新日期:2010-01-05 00:00:00
abstract::This single case report describes a large (giant) left internal carotid aneurysm that showed a very marked decrease in the size of its lumen on reevaluation 5 days after the initial arteriogram. A review of the literature found only 5 cases of spontaneous thrombosis documented by arteriography and only one involved a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.4.334
更新日期:1976-04-01 00:00:00
abstract::Eighty-one percent (47/58) of private-sector neurologists in Colorado responded to a mail survey of practice patterns. We evaluated patient load, degree of principal versus consultative care, and use of neurodiagnostic tests. Broad areas of neurologic education that were perceived to have been lacking during residency...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.287
更新日期:1987-02-01 00:00:00
abstract::Arm-diaphragm synkinesis may occur after injury to the proximal portion of the brachial plexus or cervical nerve roots. Regenerating axons of phrenic motor neurons are misdirected to supply limb muscles. Electrodiagnostic investigations of three patients with symptoms referable to upper brachial plexus or cervical roo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.4.339
更新日期:1980-04-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract::We undertook serial clinical and electromyographic muscle action potential (MAP) amplitude assessments in nine patients with the Lambert-Eaton myasthenic syndrome (LEMS) over 0.5 to 2.5 years who received plasma exchange (PE; 5 to 15 exchanges over 4 to 19 days) and immunosuppressive drug (IS) treatment (prednisolone ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.4.480
更新日期:1984-04-01 00:00:00
abstract::We investigated tyrosine-hydroxylase (TH)-immunoreactive neurons in the medulla oblongata corresponding to the A1 and A2 cell groups in autopsy tissue of patients with Parkinson's disease (PD) (n = 3), progressive supranuclear palsy (PSP) (n = 3), striatonigral degeneration (SND) (n = 2), and in controls (n = 4). The ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.11.1739
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.55.6.805
更新日期:2000-09-26 00:00:00
abstract::Neurofibromatosis 2 (NF2), a dominantly inherited disorder, typically manifests as bilateral vestibular schwannomas and predisposes to other nervous system tumors. In this study, we present a large pedigree with a benign course of NF2 (mild Gardner type) characterized by slowly growing vestibular schwannomas but few o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.7.1314
更新日期:1995-07-01 00:00:00
abstract::Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.10.1872
更新日期:1994-10-01 00:00:00
abstract::Clinical trials have demonstrated that risk of cardiovascular events may be reduced in patients with stroke, using blood pressure (BP) reduction and statin therapy, independently of the presence of specific risk factors. These results suggest an alternative approach to secondary stroke prevention, focused more on glob...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000171745.13592.cb
更新日期:2005-07-12 00:00:00
abstract:OBJECTIVE:To determine the potential of detection in CSF of specific Borrelia burgdorferi antigen, OspA, as a marker of infection in neurologic Lyme disease and compare this with the detection of antibody. DESIGN:CSF from 83 neurologic patients in an area highly endemic for Lyme disease was examined prospectively for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.11.2010
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS:Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000042048.85204.3d
更新日期:2003-01-28 00:00:00
abstract::We studied 25 patients within 6 hours of acute spinal cord injury using magnetically evoked cortical motor evoked potentials (MEPs). The subjects included 16 quadriplegics with cervical spine injuries and eight paraplegics. MEPs were recorded from abductor digiti minimi (ADM), biceps, flexor hallucis brevis, and tibia...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.2.303
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:Dominant, left anteromedial temporal lobe resection (AMTLR) for seizure control carries risks to verbal episodic memory and visual object naming. Consistent with traditional thinking, verbal memory decline is considered a consequence of hippocampal removal and naming decline has been attributed to lateral tem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dd40f0
更新日期:2010-05-11 00:00:00
abstract:OBJECTIVES:To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls). METHODS:Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single nucleotide polymorphism (SNP) genotyping was conducte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829bfe2f
更新日期:2013-07-16 00:00:00
abstract::In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to t...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000002571
更新日期:2016-04-12 00:00:00
abstract::Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.1.30
更新日期:1989-01-01 00:00:00
abstract::Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000064166.82077.eb
更新日期:2003-05-27 00:00:00