Abstract:
:The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survived (p < 0.001). Early intervention with IV rather than enteral L-carnitine was associated with the greatest hepatic survival. Specifically, all 10 patients who were diagnosed in <5 days and treated with IV L-carnitine survived. Most patients had features of chronic illness and most children appeared to be malnourished.
journal_name
Neurologyjournal_title
Neurologyauthors
Bohan TP,Helton E,McDonald I,König S,Gazitt S,Sugimoto T,Scheffner D,Cusmano L,Li S,Koch Gdoi
10.1212/wnl.56.10.1405subject
Has Abstractpub_date
2001-05-22 00:00:00pages
1405-9issue
10eissn
0028-3878issn
1526-632Xjournal_volume
56pub_type
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