GABAB receptor autoantibody frequency in service serologic evaluation.


OBJECTIVE:Small-cell lung carcinoma (SCLC) and limbic encephalitis are recognized γ-aminobutyric acid-B receptor (GABABR) autoantibody accompaniments. We sought to determine in a diagnostic serology laboratory the frequency and accompaniments (neurologic, oncologic, and serologic) of GABABR-immunoglobulin G (IgG). METHODS:We tested stored serum and CSF specimens from 3 patient groups for GABABR-IgG by indirect immunofluorescence on mouse brain tissue and transfected HEK293 cells. Group 1 included 3,989 patients tested for GABABR-IgG in service evaluation for suspected autoimmune encephalopathy. Group 2 included 49 patients with an unclassified CNS synaptic IgG detected (antedating descriptions of GABABR autoantibody). Group 3 included 384 patients in whom ≥1 SCLC-predictive autoantibodies had been detected. RESULTS:GABABR-specific IgG was detected in 17 patients (serum, 14; CSF, 11). N-type calcium channel antibody coexisted with GABABR-IgG in all seropositive patients of groups 1 and 2. In group 1, 7 of 3,989 patients were positive (0.2%). All had limbic encephalitis; 5 had SCLC. Four patients received immunotherapy and improved neurologically. In group 2, 5 of 49 patients were positive (10%). Three had limbic encephalitis, 1 had rapidly progressive encephalomyelopathy, and 1 had cerebellar ataxia. Two patients had SCLC and 1 had multiple myeloma. In group 3, 5 of 384 patients were positive (1.3%); titers were low (detected only by transfected cell assay). The neurologic presentations were diverse and attributable to coexisting T-cell-mediated autoimmunity (indicated by CRMP-5 IgG [2], ANNA-1 [2], and ANNA-3 [2]), rather than to GABABR-IgG. CONCLUSION:GABABR autoantibody is a marker of an uncommon but treatable paraneoplastic neurologic disorder, usually occurring in the setting of limbic encephalitis and SCLC.






Jeffery OJ,Lennon VA,Pittock SJ,Gregory JK,Britton JW,McKeon A




Has Abstract


2013-09-03 00:00:00














  • Increasing Traumatic Brain Injury Incidence during COVID-19 Pandemic in the Emergency Department of Cipto Mangunkusumo National General Hospital-A National Referral Hospital in Indonesia.

    abstract:OBJECTIVE:Evaluating the TBI incidence during the COVID-19 pandemic era compared with similar period in previous year. BACKGROUND:The emergence of SARS-CoV2 influenced the evolution of governmental and hospital policy worldwide, which might eventually impact many aspects. The incidence of many diseases in the Emergenc...


    pub_type: 杂志文章


    authors: Prawiroharjo P,Pangeran D,Supriawan H,Lastri D,Mayza A,Zairinal RA,Dewi AR,Asmaniar F,Ramli Y

    更新日期:2020-11-17 00:00:00

  • Perivascular infiltrate of memory lymphocytes and mature dendritic cells in MG thymomas.

    abstract::In thymomas associated with myasthenia gravis (MG), the authors found that perivascular infiltrates of memory lymphocytes and mature dendritic cells (DCs) were more frequent in patients with early improvement after thymectomy than in patients without response to thymectomy. Although these findings may be limited to pa...


    pub_type: 杂志文章


    authors: Nagane Y,Utsugisawa K,Akutsu H,Sato Y,Terayama Y

    更新日期:2005-09-13 00:00:00

  • Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography.

    abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...


    pub_type: 杂志文章


    authors: Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

    更新日期:1998-04-01 00:00:00

  • The phenotypic spectrum of SCN8A encephalopathy.

    abstract:OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...


    pub_type: 杂志文章


    authors: Larsen J,Carvill GL,Gardella E,Kluger G,Schmiedel G,Barisic N,Depienne C,Brilstra E,Mang Y,Nielsen JE,Kirkpatrick M,Goudie D,Goldman R,Jähn JA,Jepsen B,Gill D,Döcker M,Biskup S,McMahon JM,Koeleman B,Harris M,Bra

    更新日期:2015-02-03 00:00:00

  • Primary angiitis of the CNS and reversible cerebral vasoconstriction syndrome: A comparative study.

    abstract:OBJECTIVES:To further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS). METHODS:We compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled). RESULT...


    pub_type: 杂志文章


    authors: de Boysson H,Parienti JJ,Mawet J,Arquizan C,Boulouis G,Burcin C,Naggara O,Zuber M,Touzé E,Aouba A,Bousser MG,Pagnoux C,Ducros A

    更新日期:2018-10-16 00:00:00

  • CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery.

    abstract:OBJECTIVE:To determine whether the CT angiography (CTA) spot sign marks bleeding complications during and after surgery for spontaneous intracerebral hemorrhage (ICH). METHODS:In a 2-center study of consecutive spontaneous ICH patients who underwent CTA followed by surgical hematoma evacuation, 2 experienced readers (...


    pub_type: 杂志文章,多中心研究


    authors: Brouwers HB,Raffeld MR,van Nieuwenhuizen KM,Falcone GJ,Ayres AM,McNamara KA,Schwab K,Romero JM,Velthuis BK,Viswanathan A,Greenberg SM,Ogilvy CS,van der Zwan A,Rinkel GJ,Goldstein JN,Klijn CJ,Rosand J

    更新日期:2014-09-02 00:00:00

  • Interferon-beta-1b slows progression of atrophy in RRMS: Three-year follow-up in NAb- and NAb+ patients.

    abstract:OBJECTIVE:To determine the effect of interferon-beta-1b (IFNbeta-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly MRI. METHODS:An open-label baseline-vs-treatment cross...


    pub_type: 临床试验,杂志文章


    authors: Frank JA,Richert N,Bash C,Stone L,Calabresi PA,Lewis B,Stone R,Howard T,McFarland HF

    更新日期:2004-03-09 00:00:00

  • Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients.

    abstract:OBJECTIVES:To describe the clinical, CSF, and radiologic findings and long-term follow-up in a cohort of patients with acute disseminated encephalomyelitis (ADEM), and to determine possible prognostic factors for progression to MS. METHODS:Forty adults (28 women, mean age 33.5 years) diagnosed with ADEM were analyzed....


    pub_type: 杂志文章


    authors: Schwarz S,Mohr A,Knauth M,Wildemann B,Storch-Hagenlocher B

    更新日期:2001-05-22 00:00:00

  • Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy.

    abstract:BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...


    pub_type: 杂志文章


    authors: Ng YT,Rekate HL,Prenger EC,Wang NC,Chung SS,Feiz-Erfan I,Johnsonbaugh RE,Varland MR,Kerrigan JF

    更新日期:2008-04-22 00:00:00

  • Mild cognitive impairment: long-term course of four clinical subtypes.

    abstract:OBJECTIVE:To empirically validate the expanded concept of mild cognitive impairment (MCI), which differentiates between four clinical subtypes-amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCI-single domain, and nonamnestic MCI-multiple domains-and to examine the prevalence, course, and outcome...


    pub_type: 杂志文章,随机对照试验


    authors: Busse A,Hensel A,Gühne U,Angermeyer MC,Riedel-Heller SG

    更新日期:2006-12-26 00:00:00

  • Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

    abstract:OBJECTIVE:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients. METHODS:We sequenced TBK1 in a hospital-based cohort of 48...


    pub_type: 杂志文章


    authors: Gijselinck I,Van Mossevelde S,van der Zee J,Sieben A,Philtjens S,Heeman B,Engelborghs S,Vandenbulcke M,De Baets G,Bäumer V,Cuijt I,Van den Broeck M,Peeters K,Mattheijssens M,Rousseau F,Vandenberghe R,De Jonghe P,Cras P

    更新日期:2015-12-15 00:00:00

  • A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia.

    abstract::We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 develo...


    pub_type: 杂志文章


    authors: Skoog I,Wallin A,Fredman P,Hesse C,Aevarsson O,Karlsson I,Gottfries CG,Blennow K

    更新日期:1998-04-01 00:00:00

  • Central nervous system disease in patients with systemic lupus erythematosus.

    abstract::Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...


    pub_type: 杂志文章


    authors: Futrell N,Schultz LR,Millikan C

    更新日期:1992-09-01 00:00:00

  • Search for autonomously proliferating spinal fluid lymphocytes in patients with multiple sclerosis.

    abstract::Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In v...


    pub_type: 杂志文章


    authors: Birnbaum G,Aubitz S,Kotilinek L

    更新日期:1988-01-01 00:00:00

  • Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.

    abstract:OBJECTIVE:To identify the disease-causing gene of a family with upper limb predominant, slowly progressive amyotrophic lateral sclerosis (ALS), which was diagnosed as flail arm syndrome (FAS). METHODS:After causation of 24 known ALS genes was excluded by targeted next-generation sequencing, whole-exome sequencing was ...


    pub_type: 杂志文章


    authors: Liu Q,Shu S,Wang RR,Liu F,Cui B,Guo XN,Lu CX,Li XG,Liu MS,Peng B,Cui LY,Zhang X

    更新日期:2016-10-25 00:00:00

  • Experimental spinal cord injury: effects of trauma or ischemia on TRH and muscarinic receptors.

    abstract::Traumatic spinal cord injury in rats and ischemic spinal cord injury in rabbits were associated with time-dependent, localized decreases in thyrotropin-releasing hormone (TRH) and muscarinic receptor binding. Changes were not evident in the first 24 to 48 hours, consistent with the hypothesis that secondary alteration...


    pub_type: 杂志文章


    authors: Faden AI,Pilotte NS,Burt DR

    更新日期:1986-05-01 00:00:00

  • Thrombolytic stroke therapy: past, present, and future.

    abstract::Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management is changing the approach to stroke patients. The development process has been difficult and the current treatment recommendations have been controversial. Rece...


    pub_type: 杂志文章,评审


    authors: Zivin JA

    更新日期:1999-07-13 00:00:00

  • Prospective associations between white matter hyperintensities and lower extremity function.

    abstract:OBJECTIVE:To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints. METHODS:We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and fr...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Moon SY,de Souto Barreto P,Rolland Y,Chupin M,Bouyahia A,Fillon L,Mangin JF,Andrieu S,Cesari M,Vellas B,MAPT\/DSA Study Group.

    更新日期:2018-04-10 00:00:00

  • Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene.

    abstract::We report a family with an X-linked recessive disorder characterized by muscle cramps and myalgia. Nine affected male family members had high resting serum levels of creatine kinase, and well-developed musculature with calf hypertrophy but no evidence of muscular weakness. Symptoms began in childhood and did not progr...


    pub_type: 杂志文章


    authors: Gospe SM Jr,Lazaro RP,Lava NS,Grootscholten PM,Scott MO,Fischbeck KH

    更新日期:1989-10-01 00:00:00

  • Sex disparities in access to caregiving in Parkinson disease.

    abstract:OBJECTIVE:To compare access to caregiving between men and women with Parkinson disease (PD). METHODS:This was a cross-sectional and longitudinal study among participants with PD enrolled in the National Parkinson Foundation Parkinson's Outcomes Project from 2009 to 2014 at 21 international sites. The primary outcome m...


    pub_type: 杂志文章


    authors: Dahodwala N,Shah K,He Y,Wu SS,Schmidt P,Cubillos F,Willis AW

    更新日期:2018-01-02 00:00:00

  • Coccidioidal meningitis and brain abscesses: analysis of 71 cases at a referral center.

    abstract:OBJECTIVE:Coccidioides species are the most common etiologic agents of chronic meningitis in regions endemic for coccidioidomycosis. Occasionally, even short-term travel to endemic regions results in the acquisition of meningeal disease, so awareness of this complication of coccidioidomycosis is important even in nonen...


    pub_type: 杂志文章


    authors: Drake KW,Adam RD

    更新日期:2009-11-24 00:00:00

  • Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies.

    abstract:OBJECTIVE:To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome, and multifocal motor neuropathy, and to determine the added...


    pub_type: 杂志文章


    authors: Herraets IJT,Goedee HS,Telleman JA,van Eijk RPA,van Asseldonk JT,Visser LH,van den Berg LH,van der Pol WL

    更新日期:2020-04-07 00:00:00

  • Dialysis encephalopathy: a possible seizure disorder.

    abstract::Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities i...


    pub_type: 杂志文章


    authors: Nadel AM,Wilson WP

    更新日期:1976-12-01 00:00:00

  • Surgery for intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...


    pub_type: 杂志文章,评审


    authors: Fayad PB,Awad IA

    更新日期:1998-09-01 00:00:00

  • Migraine, headache, and the risk of stroke in women: a prospective study.

    abstract:BACKGROUND:Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse. METHODS:A prospective cohort study was conducted among 39,754 US health pr...


    pub_type: 杂志文章


    authors: Kurth T,Slomke MA,Kase CS,Cook NR,Lee IM,Gaziano JM,Diener HC,Buring JE

    更新日期:2005-03-22 00:00:00

  • Prehospital selection of thrombectomy candidates beyond large vessel occlusion: M-DIRECT scale.

    abstract:OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...


    pub_type: 杂志文章


    authors: Rodríguez-Pardo J,Riera-López N,Fuentes B,Alonso de Leciñana M,Secades-García S,Álvarez-Fraga J,Busca-Ostolaza P,Carneado-Ruiz J,Díaz-Guzmán J,Egido-Herrero J,Gil-Núñez A,Masjuan-Vallejo J,Real-Martínez V,Vivancos-Mora J,Díez

    更新日期:2020-02-25 00:00:00

  • Impairment of hand movements under visual guidance.

    abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...


    pub_type: 杂志文章


    authors: Damasio AR,Benton AL

    更新日期:1979-02-01 00:00:00

  • Computerized tomography in demyelinating disease of the young.

    abstract::We have used computerized tomography (CT) to look for evidence of cerebral demyelination in children with progressive neurologic disorders. Fourteen patients with a clinical diagnosis of a demyelinating disorder were examined by CT, and five had CT findings suggesting cerebral demyelination. In two patients with a so-...


    pub_type: 杂志文章


    authors: Robertson WC Jr,Gomez MR,Reese DF,Okazaki H

    更新日期:1977-09-01 00:00:00

  • Prevalence of MRI abnormalities in people with epilepsy in rural China.

    abstract:OBJECTIVE:To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom. METHODS:Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and Decembe...


    pub_type: 杂志文章


    authors: Davagnanam I,Chen Z,Hoskote C,Ding D,Yang B,Wang Y,Wang T,Li W,Duncan JS,Wang W,Sander JW,Kwan P

    更新日期:2020-09-01 00:00:00

  • Practical approaches to incidental findings in brain imaging research.

    abstract::A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...


    pub_type: 杂志文章,评审


    authors: Illes J,Kirschen MP,Edwards E,Bandettini P,Cho MK,Ford PJ,Glover GH,Kulynych J,Macklin R,Michael DB,Wolf SM,Grabowski T,Seto B

    更新日期:2008-01-29 00:00:00