Cerebral vasocapacitance and TIAs.

Abstract:

:We report the vasocapacitance of the cerebral circulation, as determined by cerebral blood flow reactivity to induced hypercapnia using fluoromethane positron emission tomography, in 32 patients with unilateral anterior circulation transient ischemic attacks. A hemodynamic subset of eight patients, defined based on exertional, positional, orthostatic, or cardiac dysrhythmic induction of symptomatology, is characterized by multiple (median, 4.5 attacks per patient), brief (median, 2.5 minutes per attack), continued episodes of hemispheric ischemia including focal limb shaking. Symptomatic middle cerebral artery flow territories show significantly lower (p less than 0.04) and more asymmetric (p = 0.036) vasodilatory responses in the hemodynamic subset. Although ipsilateral internal carotid artery occlusion is more prevalent in the hemodynamic subset, the features of age, mean arterial blood pressure, carbon dioxide values, serum glucose, serum hematocrit, and number or type of risk factors do not differ significantly between groups. These studies of vasocapacitance help validate clinical criteria for cerebral hemodynamic events with an objective physiologic measurement.

journal_name

Neurology

journal_title

Neurology

authors

Levine RL,Lagreze HL,Dobkin JA,Hanson JM,Satter MR,Rowe BR,Nickles RJ

doi

10.1212/wnl.39.1.25

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

25-9

issue

1

eissn

0028-3878

issn

1526-632X

journal_volume

39

pub_type

杂志文章
  • Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy.

    abstract::Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakness. Twenty-five of 28 patients said they would have the surgery...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.4.1159

    authors: Morgenlander JC,Lynch JR,Sanders DB

    更新日期:1997-10-01 00:00:00

  • Racial differences in statin adherence following hospital discharge for ischemic stroke.

    abstract:OBJECTIVE:To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS:We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days follo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003910

    authors: Albright KC,Zhao H,Blackburn J,Limdi NA,Beasley TM,Howard G,Bittner V,Howard VJ,Muntner P

    更新日期:2017-05-09 00:00:00

  • Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation.

    abstract::We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.5.1398

    authors: Chen R,Classen J,Gerloff C,Celnik P,Wassermann EM,Hallett M,Cohen LG

    更新日期:1997-05-01 00:00:00

  • Keeping people with epilepsy safe during the COVID-19 pandemic.

    abstract:OBJECTIVES:To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel cor...

    journal_title:Neurology

    pub_type: 共识发展会议,杂志文章

    doi:10.1212/WNL.0000000000009632

    authors: French JA,Brodie MJ,Caraballo R,Devinsky O,Ding D,Jehi L,Jette N,Kanner A,Modi AC,Newton CR,Patel AA,Pennell PB,Perucca E,Sander JW,Scheffer IE,Singh G,Williams E,Wilmshurst J,Cross JH

    更新日期:2020-06-09 00:00:00

  • Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans.

    abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000010617

    authors: Kornblith E,Peltz CB,Xia F,Plassman B,Novakovic-Apopain T,Yaffe K

    更新日期:2020-09-29 00:00:00

  • Network dysfunction predicts speech production after left hemisphere stroke.

    abstract:OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002537

    authors: Geranmayeh F,Leech R,Wise RJS

    更新日期:2016-04-05 00:00:00

  • The practice of neurology: Looking ahead by looking back.

    abstract::Over the last 50 years, there have been many improvements in therapy for individuals with neurologic disorders. Simultaneously, the complexity and cost of care have increased. The delivery of neurologic services is inefficient. The needs of both patients and neurologists are not being optimally addressed. Although gre...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0000000000001589

    authors: Ringel SP

    更新日期:2015-05-19 00:00:00

  • The utility and generality of Mini-Mental State Examination scores in Alzheimer's disease.

    abstract::The present study sought to evaluate the validity and generality of the Mini-Mental State Examination (MMSE) and its subsection scores. We gave the MMSE and other neuropsychological tests to 51 patients with probable Alzheimer's disease. On the basis of correlational and factor analyses, overall performance on the MMS...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.12.1894

    authors: Giordani B,Boivin MJ,Hall AL,Foster NL,Lehtinen SJ,Bluemlein LA,Berent S

    更新日期:1990-12-01 00:00:00

  • Experimental pain assessment in patients with poststroke aphasia.

    abstract:OBJECTIVE:To evaluate an observational-behavioral pain tool among individuals with acute poststroke aphasia. METHODS:We performed a randomized, double-blind, controlled study of experimental pain assessment among 36 adult patients with acute poststroke aphasia. Patients were administered 3 levels of mechanical pain, i...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0000000000006081

    authors: Soares CD,Panuganti PK,Shrivastava A,Aroor S,Keinath KM,Bromagen MC,Howard ME,Carlson C,Smith JH

    更新日期:2018-08-28 00:00:00

  • A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy.

    abstract:OBJECTIVE:To evaluate topiramate as monotherapy in adults and children with recently diagnosed, localization-related epilepsy, comparing two dosages of topiramate in a multicenter, randomized, double-blind study. METHODS:Adults and children (>/=3 years of age) were eligible if the maximum interval since epilepsy diagn...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.wnl.0000048200.12663.bc

    authors: Gilliam FG,Veloso F,Bomhof MA,Gazda SK,Biton V,Ter Bruggen JP,Neto W,Bailey C,Pledger G,Wu SC

    更新日期:2003-01-28 00:00:00

  • Small-fiber neuropathy in patients with ALS.

    abstract:OBJECTIVE:To investigate the involvement of the epidermal small sensory fibers in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). METHODS:In the present study, skin biopsies of 28 patients with ALS were obtained at an average of 34 months after disease onset by history. Protein gene product 9.5 (...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31821e553a

    authors: Weis J,Katona I,Müller-Newen G,Sommer C,Necula G,Hendrich C,Ludolph AC,Sperfeld AD

    更新日期:2011-06-07 00:00:00

  • Hydromyelia associated with arrested hydrocephalus.

    abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.4.652

    authors: Olson DM,Milstein JM

    更新日期:1988-04-01 00:00:00

  • A comparative study of the cerebrovascular complications of cocaine: alkaloidal versus hydrochloride--a review.

    abstract::Cocaine, especially in its alkaloidal or "crack" form, has been increasingly associated with cerebrovascular disease. Before the crack epidemic, cocaine hydrochloride (HCl) was also implicated as a cause of stroke. However, less is known about the differences in stroke subtypes, age at stroke onset, or presence of und...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.41.8.1173

    authors: Levine SR,Brust JC,Futrell N,Brass LM,Blake D,Fayad P,Schultz LR,Millikan CH,Ho KL,Welch KM

    更新日期:1991-08-01 00:00:00

  • Penetrating war injuries of the basal forebrain: neurology and cognition.

    abstract::We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.4.459

    authors: Salazar AM,Grafman J,Schlesselman S,Vance SC,Mohr JP,Carpenter M,Pevsner P,Ludlow C,Weingartner H

    更新日期:1986-04-01 00:00:00

  • Caregivers' preferences for the treatment of patients with Alzheimer's disease.

    abstract:OBJECTIVES:To learn caregivers' preferences for the treatment of AD with a disease-slowing therapy, and to identify relationships between these preferences and the characteristics of caregivers and patients. METHODS:A structured interview with 40 caregivers of patients with AD. Preferences were measured for an AD-slow...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.7.1008

    authors: Karlawish JH,Klocinski JL,Merz J,Clark CM,Asch DA

    更新日期:2000-10-10 00:00:00

  • Infarction in the anterior rostral cerebellum (the territory of the lateral branch of the superior cerebellar artery).

    abstract::We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.2_part_1.253

    authors: Amarenco P,Roullet E,Goujon C,Chéron F,Hauw JJ,Bousser MG

    更新日期:1991-02-01 00:00:00

  • Symptomatic dysferlin gene mutation carriers: characterization of two cases.

    abstract:OBJECTIVE:To describe two symptomatic dysferlin gene mutation carriers. METHODS:One patient had limb girdle weakness. His brother was diagnosed with limb girdle muscular dystrophy 2B with two mutations in the dysferlin gene (D625Y and E1734G). The second patient had distal weakness. He had two sons with Miyoshi myopat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000256768.79353.60

    authors: Illa I,De Luna N,Domínguez-Perles R,Rojas-García R,Paradas C,Palmer J,Márquez C,Gallano P,Gallardo E

    更新日期:2007-04-17 00:00:00

  • Idiopathic intracranial hypertension: relationship to depression, anxiety, and quality of life.

    abstract:OBJECTIVE:To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.2.319

    authors: Kleinschmidt JJ,Digre KB,Hanover R

    更新日期:2000-01-25 00:00:00

  • An evaluation of the predictive validity and inter-rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type.

    abstract::Several recent autopsy studies suggest that senile dementia of Lewy body type (SDLT) may be the second most common neuropathologic cause of dementia in the elderly, accounting for 7 to 30% of all cases. Operational criteria for the antemortem clinical diagnosis of SDLT have already been proposed by our group. The perf...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.5.872

    authors: McKeith IG,Fairbairn AF,Bothwell RA,Moore PB,Ferrier IN,Thompson P,Perry RH

    更新日期:1994-05-01 00:00:00

  • Predictive role of heterozygous p.R4810K of RNF213 in the phenotype of Chinese moyamoya disease.

    abstract:OBJECTIVE:Precise genetic analyses were conducted with ring finger protein 213 (RNF213) in relation to a particular clinical phenotype in Chinese patients with moyamoya disease (MMD) to determine whether heterozygosity is responsible for the early-onset and severe form of this disease. METHODS:A case-control study for...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008901

    authors: Wang Y,Zhang Z,Wei L,Zhang Q,Zou Z,Yang L,Li D,Shang M,Han C,Mambiya M,Bao X,Li Q,Hao F,Zhang K,Wang H,Liu S,Liu M,Zeng F,Nie F,Wang K,Liu W,Duan L

    更新日期:2020-02-18 00:00:00

  • Treatment of AIDS-associated myelopathy with L-methionine: a placebo-controlled study.

    abstract:BACKGROUND:The histopathology of AIDS-associated myelopathy (AM) closely resembles that of myelopathies due to cobalamin or folate deficiency, with white matter vacuolization in the spinal cord. The pathogenesis of AM appears unrelated to direct HIV infection of the spinal cord. There is abnormal trans-methylation meta...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000140469.18782.05

    authors: Di Rocco A,Werner P,Bottiglieri T,Godbold J,Liu M,Tagliati M,Scarano A,Simpson D

    更新日期:2004-10-12 00:00:00

  • Survival and outcome after endotracheal intubation for acute stroke.

    abstract:OBJECTIVE:To assess survival and functional outcome in patients endotracheally intubated after ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH). BACKGROUND:Endotracheal intubation is both a necessary life support intervention and a measure of severity in IS or ICH. Knowledge of associated clinical va...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.7.1374

    authors: Bushnell CD,Phillips-Bute BG,Laskowitz DT,Lynch JR,Chilukuri V,Borel CO

    更新日期:1999-04-22 00:00:00

  • Ocular fundus photography of patients with focal neurologic deficits in an emergency department.

    abstract:OBJECTIVES:We evaluated the frequency and predictive value of ocular fundus abnormalities among patients who presented to the emergency department (ED) with focal neurologic deficits to determine the utility of these findings in the evaluation of patients with suspected TIA and stroke. METHODS:In this cross-sectional ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001759

    authors: Vuong LN,Thulasi P,Biousse V,Garza P,Wright DW,Newman NJ,Bruce BB

    更新日期:2015-07-21 00:00:00

  • Significance of circadian rhythms in severely brain-injured patients: A clue to consciousness?

    abstract:OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003942

    authors: Blume C,Lechinger J,Santhi N,del Giudice R,Gnjezda MT,Pichler G,Scarpatetti M,Donis J,Michitsch G,Schabus M

    更新日期:2017-05-16 00:00:00

  • Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.

    abstract:OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000003690

    authors: Cervenka MC,Hocker S,Koenig M,Bar B,Henry-Barron B,Kossoff EH,Hartman AL,Probasco JC,Benavides DR,Venkatesan A,Hagen EC,Dittrich D,Stern T,Radzik B,Depew M,Caserta FM,Nyquist P,Kaplan PW,Geocadin RG

    更新日期:2017-03-07 00:00:00

  • Age- and sex-specific analysis of patients with embolic stroke of undetermined source.

    abstract:OBJECTIVE:To investigate whether the correlation of age and sex with the risk of recurrence and death seen in patients with previous ischemic stroke is also evident in patients with embolic stroke of undetermined source (ESUS). METHODS:We pooled datasets of 11 stroke registries from Europe and America. ESUS was define...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004199

    authors: Ntaios G,Lip GYH,Vemmos K,Koroboki E,Manios E,Vemmou A,Rodríguez-Campello A,Cuadrado-Godia E,Roquer J,Arnao V,Caso V,Paciaroni M,Diez-Tejedor E,Fuentes B,Pérez Lucas J,Arauz A,Ameriso SF,Pertierra L,Gómez-Schneider M

    更新日期:2017-08-08 00:00:00

  • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group.

    abstract::The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.50.1.136

    authors: Rogers SL,Farlow MR,Doody RS,Mohs R,Friedhoff LT

    更新日期:1998-01-01 00:00:00

  • PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women.

    abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011149

    authors: Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

    更新日期:2020-11-18 00:00:00

  • The Wernicke area: Modern evidence and a reinterpretation.

    abstract::The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000002219

    authors: Binder JR

    更新日期:2015-12-15 00:00:00

  • Predicting developmental outcomes in preterm infants: A simple white matter injury imaging rule.

    abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008172

    authors: Cayam-Rand D,Guo T,Grunau RE,Benavente-Fernández I,Synnes A,Chau V,Branson H,Latal B,McQuillen P,Miller SP

    更新日期:2019-09-24 00:00:00