Persistence of varicella-zoster virus DNA in elderly patients with postherpetic neuralgia.

abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting the central nervous system as a result of reactivation of the John Cunningham (JC) polyomavirus and occurs almost exclusively in immunosuppressed individuals. The disease course of PML is variable but usually progressive and often fa...

journal_title：Journal of neurovirology

authors： Holmes A,Wellings T,Walsh O,Rowlings P

更新日期：2020-12-01 00:00:00

abstract：:There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...

journal_title：Journal of neurovirology

authors： Mubanga E,Patel A,Siddiqi OK,Hanson BA,Dang X,Lakhi S,Mulundu G,Bender N,Koralnik IJ

更新日期：2019-08-01 00:00:00

abstract：:HIV-1 viral proteins have been implicated in endothelial dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on viral replication, reactivation o...

journal_title：Journal of neurovirology

authors： McMullen K,Bateman K,Stanley A,Combrinck M,Engelbrecht S,Bryer A

更新日期：2021-01-18 00:00:00

abstract：:HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...

journal_title：Journal of neurovirology

authors： Anderson AM,Lennox JL,Mulligan MM,Loring DW,Zetterberg H,Blennow K,Kessing C,Koneru R,Easley K,Tyor WR

更新日期：2017-02-01 00:00:00

abstract：:Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...

journal_title：Journal of neurovirology

authors： Seider TR,Gongvatana A,Woods AJ,Chen H,Porges EC,Cummings T,Correia S,Tashima K,Cohen RA

更新日期：2016-04-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...

journal_title：Journal of neurovirology

authors： Kennedy PG,Cohrs RJ

更新日期：2010-11-01 00:00:00

abstract：:Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...

journal_title：Journal of neurovirology

authors： Harbison C,Zhuang K,Gettie A,Blanchard J,Knight H,Didier P,Cheng-Mayer C,Westmoreland S

更新日期：2014-02-01 00:00:00

abstract：:Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...

journal_title：Journal of neurovirology

authors： Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

更新日期：2017-08-01 00:00:00

abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...

journal_title：Journal of neurovirology

authors： Pérez-Santiago J,De Oliveira MF,Var SR,Day TRC,Woods SP,Gianella S,Mehta SR

更新日期：2017-04-01 00:00:00

abstract：:Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana vir...

journal_title：Journal of neurovirology

authors： Valassina M,Cusi MG,Valensin PE

更新日期：2003-12-01 00:00:00

abstract：:Despite common clinical features to suggest encephalitis, different viral encephalitides are known to have some specific clinical features, which if present, may suggest infection by a particular virus. West Nile viral (WNV) encephalitis has not been described with any specific diagnostic feature so far. In this conte...

journal_title：Journal of neurovirology

authors： Pradhan S,Anand S,Choudhury SS

更新日期：2019-06-01 00:00:00

abstract：:Therapy for progressive multifocal leukoencephalopathy (PML) remains challenging since there are no antiviral therapies available for JC virus. Immune reconstitution has improved the prognosis in many settings where PML occurs, but it often is not possible in PML patients with hematologic malignancies. We describe the...

journal_title：Journal of neurovirology

authors： Hoang E,Bartlett NL,Goyal MS,Schmidt RE,Clifford DB

更新日期：2019-04-01 00:00:00

abstract：:The recent ability to quantitate and localize the interaction of antigen-specific T cells in the central nervous system during infectious and autoimmune diseases will greatly enhance our understanding of the molecular and biologic basis of virus-induced diseases of the nervous and other systems. ...

journal_title：Journal of neurovirology

authors： Oldstone MB

更新日期：2004-08-01 00:00:00

abstract：:HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...

journal_title：Journal of neurovirology

authors： Bratanich AC,Liu C,McArthur JC,Fudyk T,Glass JD,Mittoo S,Klassen GA,Power C

更新日期：1998-08-01 00:00:00

abstract：:Pooled human immunoglobulin (IgG) was evaluated as prophylaxis and treatment of HSV-1 infection in mice. We compared the effects of IgG on the course of acute infection and spread of virus through the nervous system, as well as on the establishment, maintenance, and reactivation of virus from latency. Balb/c mice rece...

journal_title：Journal of neurovirology

authors： Dalai SK,Pesnicak L,Miller GF,Straus SE

更新日期：2002-02-01 00:00:00

abstract：:Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...

journal_title：Journal of neurovirology

authors： Tate DF,Sampat M,Harezlak J,Fiecas M,Hogan J,Dewey J,McCaffrey D,Branson D,Russell T,Conley J,Taylor M,Schifitto G,Zhong J,Daar ES,Alger J,Brown M,Singer E,Campbell T,McMahon D,Tso Y,Matesan J,Letendre S,Paulo

更新日期：2011-08-01 00:00:00

abstract：:Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...

journal_title：Journal of neurovirology

authors： Portolani M,Sabbatini AM,Meacci M,Pietrosemoli P,Cermelli C,Lunghi P,Golinelli F,Stacca R

更新日期：1998-08-01 00:00:00

abstract：:Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...

journal_title：Journal of neurovirology

authors： Keltner JR,Fennema-Notestine C,Vaida F,Wang D,Franklin DR,Dworkin RH,Sanders C,McCutchan JA,Archibald SL,Miller DJ,Kesidis G,Cushman C,Kim SM,Abramson I,Taylor MJ,Theilmann RJ,Julaton MD,Notestine RJ,Corkran S,Chern

更新日期：2014-06-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...

journal_title：Journal of neurovirology

authors： Guan X,Liu J,Jiang H,Wu CX,Chen HC,Liu ZF

更新日期：2018-10-01 00:00:00

abstract：:Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...

journal_title：Journal of neurovirology

authors： Hay KA,Edris WA,Gaydos A,Tenser RB

更新日期：1998-10-01 00:00:00

abstract：:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of...

journal_title：Journal of neurovirology

authors： Hobbs JA

更新日期：2006-06-01 00:00:00

abstract：:The brain's intrinsic immune system consists of glial cells that produce cytokines and chemokines in response to stimulation with cytomegalovirus (CMV). The present experiments were undertaken to determine whether this intrinsic glial cell response alone is sufficient to control CMV infection of the central nervous sy...

journal_title：Journal of neurovirology

authors： Cheeran MC,Gekker G,Hu S,Min X,Cox D,Lokensgard JR

更新日期：2004-06-01 00:00:00

abstract：:The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 103 and 5 × 105 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C...

journal_title：Journal of neurovirology

authors： Canivet C,Uyar O,Rhéaume C,Piret J,Boivin G

更新日期：2019-06-01 00:00:00

abstract：:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...

journal_title：Journal of neurovirology

authors： Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

更新日期：2013-04-01 00:00:00

abstract：:The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...

journal_title：Journal of neurovirology

authors： Bestetti A,Presi S,Pierotti C,Bossolasco S,Sala S,Racca S,Carrera P,Lazzarin A,Cinque P

更新日期：2004-01-01 00:00:00

abstract：:Nipah virus is a recently emergent paramyxovirus that is capable of causing severe disease in both humans and animals. The first outbreak of Nipah virus occurred in Malaysia and Singapore in 1999 and, more recently, outbreaks were detected in Bangladesh. In humans, Nipah virus causes febrile encephalitis with respirat...

journal_title：Journal of neurovirology

authors： Bellini WJ,Harcourt BH,Bowden N,Rota PA

更新日期：2005-10-01 00:00:00

abstract：:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...

journal_title：Journal of neurovirology

authors： Tsunoda I,Tanaka T,Taniguchi M,Fujinami RS

更新日期：2009-01-01 00:00:00

abstract：:In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...

journal_title：Journal of neurovirology

authors： Nagai M,Usuku K,Matsumoto W,Kodama D,Takenouchi N,Moritoyo T,Hashiguchi S,Ichinose M,Bangham CR,Izumo S,Osame M

更新日期：1998-12-01 00:00:00

abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

journal_title：Journal of neurovirology

authors： Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

更新日期：2006-10-01 00:00:00

abstract：:The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

journal_title：Journal of neurovirology

authors： Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

更新日期：1999-12-01 00:00:00