Diplopia as isolated presentation of varicella zoster central nervous system reactivation.

Abstract:

:Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivation of VZV infection was made without the presence of characteristic vesicular rash. Quantitative real-time PCR for VZV and intrathecal dosage of VZV IgM and IgG should be performed in cases suspected for viral encephalitis and also in all patients with not otherwise attributable cranial nerve lesions.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

doi

10.1007/s13365-017-0534-z

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

621-624

issue

4

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-017-0534-z

journal_volume

23

pub_type

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