当前位置： SCI文献检索 > JOURNAL OF NEUROVIROLOGY期刊下所有文献 > Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex.

Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex.

Abstract：

:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of parvovirus B19 (B19) infection with various neurological and neuropsychiatric symptoms. Adeno-associated virus 2 (AAV2) is related to B19 but has thus far not been shown to be associated with any human disease but is of clinical interest because of the recent use of recombinant AAV vectors in human gene therapy, including gene delivery to the brain. To date, there have been no large-scale studies of the propensity of wild-type human parvoviruses to infect the brain. The Stanley Medical Research Institute Brain Collection offered a unique opportunity to study a large sample (n = 104) of dorsolateral prefrontal cortex (DLPC) DNAs isolated from unaffected control, schizophrenic, and bipolar disorder brains for the presence of parvoviral sequences. This is the first investigator-blinded study to document the presence of parvoviral sequences in the DLPC by utilizing highly sensitive nested polymerase chain reaction (nPCR) and DNA sequencing. Of the overall sample, 6.7% to 12.5% were positive for AAV2, and 14.4% to 42.3% were positive for B19 sequences, with no statistical differences among subgroups. This is the first report to demonstrate the presence of human parvoviruses in a large cohort of adult DLPC, which underscores the need to gain a better insight into the basic biology of parvovirus-brain interactions, including mechanisms of infection and persistence.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Hobbs JA

doi

10.1080/13550280600827351

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

190-9

issue

3

eissn

1355-0284

issn

1538-2443

pii

V353Q5728J462057

journal_volume

12

pub_type

杂志文章

相关文献

JOURNAL OF NEUROVIROLOGY文献大全
  • Nonhuman primate models of NeuroAIDS.

    abstract：:Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：10.1080/13550280802074539

    authors： Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

    更新日期：2008-08-01 00:00:00

  • Neurocytotoxity of quinolinic acid in human brain cultures.

    abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.3109/13550289509111027

    authors： Kerr SJ,Armati PJ,Brew BJ

    更新日期：1995-12-01 00:00:00

  • Relationship between brain large artery characteristics and their downstream arterioles.

    abstract：:We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-t...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-017-0606-0

    authors： Gutierrez J,Murray J,Chon C,Morgello S

    更新日期：2018-02-01 00:00:00

  • Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study.

    abstract：:HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-012-0135-9

    authors： Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

    更新日期：2013-02-01 00:00:00

  • Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy.

    abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.3109/13550289509111008

    authors： Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

    更新日期：1995-03-01 00:00:00

  • Peripheral polyneuropathy associated with Chikungunya virus infection.

    abstract：:The Chikungunya virus (CHIKV) is an arbovirus transmitted to humans through mosquito bites and can cause a series of symptoms ranging from a benign febrile illness to severe neurological conditions. We report the identification of CHIKV in a serum sample from an elderly woman with febrile illness and severe arthralgia...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-019-00782-7

    authors： Silva VP,Costa DS,Carvalho VCCVL,Garcês TCCS,Barros ELT,Oliveira JS,Pereira ACTC,Ferreira GP

    更新日期：2020-02-01 00:00:00

  • HSV-1 encephalitis relapse after epilepsy surgery: a case report and review of the literature.

    abstract：:Herpes simplex encephalitis relapses have been rarely reported, with only few cases occurring after neurosurgical interventions. A young man presented a late herpes simplex encephalitis relapse after left antero-mesial temporal resection for his refractory temporal lobe epilepsy. Eight days after surgery, he developed...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-019-00796-1

    authors： Mantero V,Cossu M,Rigamonti A,Fiumani A,Basilico P,Tassi L,Salmaggi A

    更新日期：2020-02-01 00:00:00

  • Restricted replication of herpes simplex virus in satellite glial cell cultures clonally derived from adult mice.

    abstract：:To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.3109/13550289909029479

    authors： Wilkinson R,Leaver C,Simmons A,Pereira RA

    更新日期：1999-08-01 00:00:00

  • Subtype associations with HIV-associated neurocognitive disorder in China.

    abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-015-0377-4

    authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

    更新日期：2016-04-01 00:00:00

  • The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease.

    abstract：:This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot b...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：10.1080/13550280802448451

    authors： Dolei A,Perron H

    更新日期：2009-01-01 00:00:00

  • The cellular response to herpes simplex virus type 1 (HSV-1) during latency and reactivation.

    abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280591002405

    authors： Kent JR,Fraser NW

    更新日期：2005-08-01 00:00:00

  • Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients. European Union Concerted Action on Virus Meningitis and Encephalitis.

    abstract：:Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：10.3109/13550289809113490

    authors： Cinque P,Cleator GM,Weber T,Monteyne P,Sindic C,Gerna G,van Loon AM,Klapper PE

    更新日期：1998-02-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection in Zimbabwe-2005.

    abstract：:Zimbabwe is a high prevalence area for HIV infection, and provides opportunities for studying complications of AIDS in both antiretroviral naive and treated groups of patients. Figures for HIV prevalence are among the highest in the world, but the number of people receiving treatment is very small. Economic and politi...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：10.1080/13550280500511766

    authors： Mielke J

    更新日期：2005-01-01 00:00:00

  • Global NeuroAIDS roundtable.

    abstract：:In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the "Global NeuroAIDS Roundtable" in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought toge...

    journal_title：Journal of neurovirology

    pub_type：

    doi：10.1007/s13365-012-0143-9

    authors： Joseph J,Achim CL,Boivin MJ,Brew BJ,Clifford DB,Colosi DA,Ellis RJ,Heaton RK,Gallo-Diop A,Grant I,Kanmogne GD,Kumar M,Letendre S,Marcotte TD,Nath A,Pardo CA,Paul RH,Pulliam L,Robertson K,Royal W 3rd,Sacktor N,Si

    更新日期：2013-02-01 00:00:00

  • Macrophage chemoattractant protein-1 levels in cerebrospinal fluid correlate with containment of JC virus and prognosis of acquired immunodeficiency syndrome--associated progressive multifocal leukoencephalopathy.

    abstract：:In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280590924539

    authors： Marzocchetti A,Cingolani A,Giambenedetto SD,Ammassari A,Giancola ML,Cauda R,Antinori A,Luca AD

    更新日期：2005-04-01 00:00:00

  • Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant.

    abstract：:A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.3109/13550289809114528

    authors： Strelow LI,Watry DD,Fox HS,Nelson JA

    更新日期：1998-06-01 00:00:00

  • HTLV-1 proviral load in cerebrospinal fluid may not be a good marker to differentiate asymptomatic carriers with high proviral load in blood from HAM/TSP patients.

    abstract：:An elevated human T cell leukemia virus type 1 (HTLV-1) proviral load (PVL) is an important risk factor for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although there is a considerable frequency of asymptomatic carriers (AC) with high PVL in blood. Our objective was to evaluate whether PVL qua...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-018-0632-6

    authors： Martins ML,de Freitas Carneiro-Proietti AB,Nicolato R,de Miranda DM,Romanelli LCF

    更新日期：2018-08-01 00:00:00

  • Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection.

    abstract：:Despite the high incidence of cognitive and motor impairment in acquired immunodeficiency syndrome (AIDS) patients, the mechanisms of AIDS-related central nervous system (CNS) pathology are not completely understood. Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS, in...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280390218751

    authors： Weed MR,Hienz RD,Brady JV,Adams RJ,Mankowski JL,Clements JE,Zink MC

    更新日期：2003-08-01 00:00:00

  • Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes.

    abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.3109/13550289609146542

    authors： Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

    更新日期：1996-04-01 00:00:00

  • COVID-19 and the nervous system.

    abstract：:A pandemic due to novel coronavirus arose in mid-December 2019 in Wuhan, China, and in 3 months' time swept the world. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic similarities to the virus (SARS-CoV-1) responsible for the severe acute respirator...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：10.1007/s13365-020-00840-5

    authors： Berger JR

    更新日期：2020-04-01 00:00:00

  • Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.

    abstract：:Flavivirus encephalitis is believed to be the result of two main mechanisms: (i) direct damage to and dysfunction of neurons as a result of viral replication and (ii) destruction of the brain tissue by an inflammatory response. The differential impact of both mechanisms on the progression of flavivirus encephalitis ha...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280390173319

    authors： Leyssen P,Paeshuyse J,Charlier N,Van Lommel A,Drosten C,De Clercq E,Neyts J

    更新日期：2003-02-01 00:00:00

  • Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein.

    abstract：:Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transform...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280490499524

    authors： Holmøy T,Kvale EØ,Vartdal F

    更新日期：2004-10-01 00:00:00

  • Varicella zoster virus meningitis with hypoglycorrhachia in the absence of rash in an immunocompetent woman.

    abstract：:We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1080/13550280902725550

    authors： Habib AA,Gilden D,Schmid DS,Safdieh JE

    更新日期：2009-04-01 00:00:00

  • Genetic risk factors in multiple sclerosis and approaches to their identification.

    abstract：:Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章,评审

    doi：

    authors： Rasmussen HB,Clausen J

    更新日期：2000-05-01 00:00:00

  • Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals.

    abstract：:HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-016-0466-z

    authors： Anderson AM,Lennox JL,Mulligan MM,Loring DW,Zetterberg H,Blennow K,Kessing C,Koneru R,Easley K,Tyor WR

    更新日期：2017-02-01 00:00:00

  • Machine learning models reveal neurocognitive impairment type and prevalence are associated with distinct variables in HIV/AIDS.

    abstract：:Neurocognitive impairment (NCI) among HIV-infected patients is heterogeneous in its reported presentations and frequencies. To determine the prevalence of NCI and its associated subtypes as well as predictive variables, we investigated patients with HIV/AIDS receiving universal health care. Recruited adult HIV-infecte...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-019-00791-6

    authors： Tu W,Chen PA,Koenig N,Gomez D,Fujiwara E,Gill MJ,Kong L,Power C

    更新日期：2020-02-01 00:00:00

  • Decreased MEG beta oscillations in HIV-infected older adults during the resting state.

    abstract：:The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-013-0220-8

    authors： Becker KM,Heinrichs-Graham E,Fox HS,Robertson KR,Sandkovsky U,O'Neill J,Swindells S,Wilson TW

    更新日期：2013-12-01 00:00:00

  • Increased frequency of JC virus type 2 and of dual infection with JC virus type 1 and 2 in Italian progressive multifocal leukoencephalopathy patients.

    abstract：:To verify the possibility of different role of JC virus genotypes in the etiology of progressive multifocal leukoencephalopathy, we analysed several JC virus isolates amplified from AIDS patients with and without progressive multifocal leukoencephalopathy and healthy controls by nucleotide sequencing. Cerebrospinal fl...

    journal_title：Journal of neurovirology

    pub_type： 临床试验,杂志文章

    doi：10.1080/135502801300069638

    authors： Ferrante P,Mediati M,Caldarelli-Stefano R,Losciale L,Mancuso R,Cagni AE,Maserati R

    更新日期：2001-02-01 00:00:00

  • Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness.

    abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-013-0221-7

    authors： Rahimi P,Naser HM,Siadat SD,Sohrabi A,Mostafavi E,Motamedirad M,Bahramali G,Sadat SM,Ardestani MS

    更新日期：2013-12-01 00:00:00

  • Progressive multifocal leukoencephalopathy treated with nivolumab.

    abstract：:Therapy for progressive multifocal leukoencephalopathy (PML) remains challenging since there are no antiviral therapies available for JC virus. Immune reconstitution has improved the prognosis in many settings where PML occurs, but it often is not possible in PML patients with hematologic malignancies. We describe the...

    journal_title：Journal of neurovirology

    pub_type： 杂志文章

    doi：10.1007/s13365-019-00738-x

    authors： Hoang E,Bartlett NL,Goyal MS,Schmidt RE,Clifford DB

    更新日期：2019-04-01 00:00:00