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Subtype associations with HIV-associated neurocognitive disorder in China.

Abstract：

:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4(+) counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4(+) counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

doi

10.1007/s13365-015-0377-4

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

246-50

issue

2

eissn

1355-0284

issn

1538-2443

pii

10.1007/s13365-015-0377-4

journal_volume

22

pub_type

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