Abstract:
:Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with raised titres of anti-measles antibodies in CSF and serum. Atypical presentations of SSPE have been reported including brainstem involvement, ADEM-like presentation, acute encephalitis, and cerebellar ataxia. Presentation with predominant extrapyramidal features is uncommon. We describe a case of SSPE presenting with extensive rigidity with highly elevated CPK values, mimicking neuroleptic malignant syndrome (NMS) which was most probably due to central dopaminergic blockade induced by the disease process. To our knowledge, this is the first case of SSPE presenting with a NMS-like syndrome.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Garg D,Reddy V,Singh RK,Dash D,Bhatia R,Tripathi Mdoi
10.1007/s13365-017-0602-4subject
Has Abstractpub_date
2018-02-01 00:00:00pages
128-131issue
1eissn
1355-0284issn
1538-2443pii
10.1007/s13365-017-0602-4journal_volume
24pub_type
杂志文章abstract::Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601187177
更新日期:2007-04-01 00:00:00
abstract::Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111008
更新日期:1995-03-01 00:00:00
abstract::Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-013-0229-z
更新日期:2014-02-01 00:00:00
abstract::The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0285-z
更新日期:2014-12-01 00:00:00
abstract::Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550280009013160
更新日期:2000-04-01 00:00:00
abstract::Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS mig...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00878-5
更新日期:2020-12-01 00:00:00
abstract::Chemokines and their receptors are constitutively present in the central nervous system (CNS), expressed in neurons and glial cells. Much evidence suggests that, beyond their involvement in neuroinflammation, these proteins play a role in neurodevelopment and neurophysiological signaling. The goal of this review is to...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1080/13550280290100932
更新日期:2002-12-01 00:00:00
abstract::In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0097-y
更新日期:2012-06-01 00:00:00
abstract::Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280601169837
更新日期:2007-01-01 00:00:00
abstract::The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289509111018
更新日期:1995-03-01 00:00:00
abstract::The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280500385286
更新日期:2005-12-01 00:00:00
abstract::HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhoo...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-019-00785-4
更新日期:2020-02-01 00:00:00
abstract::Development of multiple sclerosis (MS) is believed to involve genetic as well as environmental factors. A complicating aspect to the study of aetiological factors in MS concerns the possible existence of genetically different subtypes of the disease. In addition, a relatively large number of susceptibility genes could...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280701802543
更新日期:2008-01-01 00:00:00
abstract::Rabies is a neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment had severe sequelae. The present study showed that after 48 h of RABV inoculation, mice injected intracerebrally with anti-RABV F (ab')2 plus Bioporter® showed 70% survival compared to the c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00883-8
更新日期:2020-10-01 00:00:00
abstract::Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289609146542
更新日期:1996-04-01 00:00:00
abstract::Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.3109/13550289609146880
更新日期:1996-06-01 00:00:00
abstract::Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is an inflammatory disease of the spinal cord and clinically characterized by progressive spastic paraparesis, urinary incontinence, and mild sen...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-020-00881-w
更新日期:2020-10-01 00:00:00
abstract::Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::Most immunosuppressed individuals who develop progressive multifocal leukoencephalopathy (PML) have a rapid fatal outcome, whereas some become long-term survivors. We explored the impact of the cellular immune response against JC virus (JCV) on the clinical outcome of 7 HIV+ and 3 HIV- individuals with PML. Of the 4 H...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152537175
更新日期:2001-08-01 00:00:00
abstract::JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590900391
更新日期:2005-02-01 00:00:00
abstract::Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-017-0527-y
更新日期:2017-08-01 00:00:00
abstract::In 2007, the nosology for HIV-1-associated neurocognitive disorders (HAND) was updated to a primarily neurocognitive disorder. However, currently available diagnostic tools lack the sensitivity and specificity needed for an accurate diagnosis for HAND. Scientists and clinicians, therefore, have been on a quest for an ...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-018-0705-6
更新日期:2019-10-01 00:00:00
abstract::The objective of this study was to assess the long-term virological response in cerebrospinal fluid (CSF) in patients treated with highly active antiretroviral therapy (HAART) and to compare this response to CSF and plasma human immunodeficiency virus (HIV) drug resistance profiles. Paired CSF and plasma specimens wer...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/753312753
更新日期:2004-01-01 00:00:00
abstract::Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...
journal_title:Journal of neurovirology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13365-015-0352-0
更新日期:2015-10-01 00:00:00
abstract::A monocenter observational study was conducted to determine the clinical and virological effects of cidofovir added to highly active anti-retroviral therapy (HAART) in AIDS-associated progressive multifocal leukoencephalopathy (PML). Exposure to other anti-viral drugs or late initiation of cidofovir were exclusion cri...
journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章
doi:10.1080/13550280152537274
更新日期:2001-08-01 00:00:00
abstract::Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which c...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.3109/13550289809113480
更新日期:1998-02-01 00:00:00
abstract::Age-dependent poliomyelitis (ADPM) is a virally induced neuroparalytic disease of mice and a model for amyotrophic lateral sclerosis (ALS). ADPM is triggered in genetically susceptible mice by immunosuppression and infection with lactate dehydrogenase-elevating virus (LDV). Both ADPM and ALS are characterized by progr...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280152403308
更新日期:2001-06-01 00:00:00
abstract::To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280590953825
更新日期:2005-07-01 00:00:00
abstract::Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions arou...
journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-020-00843-2
更新日期:2020-10-01 00:00:00