Herpes simplex virus-1 and varicella-zoster virus latency in ganglia.

abstract：:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...

journal_title：Journal of neurovirology

authors： Tsunoda I,Tanaka T,Taniguchi M,Fujinami RS

更新日期：2009-01-01 00:00:00

abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

journal_title：Journal of neurovirology

authors： Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

更新日期：2012-06-01 00:00:00

abstract：:Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the...

journal_title：Journal of neurovirology

authors： Matthews AE,Lavi E,Weiss SR,Paterson Y

更新日期：2002-06-01 00:00:00

abstract：:Although no longer considered therapeutically beneficial, antiretroviral treatment interruptions (TIs) still occur frequently among patients with human immunodeficiency virus (HIV) infection for a variety of reasons. TIs typically result in viral rebound and worsening immunosuppression, which in turn are risk factors ...

journal_title：Journal of neurovirology

authors： Childers ME,Woods SP,Letendre S,McCutchan JA,Rosario D,Grant I,Mindt MR,Ellis RJ,San Diego HIV Neurobehavioral Research Center Group.

更新日期：2008-11-01 00:00:00

abstract：:Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which c...

journal_title：Journal of neurovirology

authors： Chebloune Y,Karr BM,Raghavan R,Singh DK,Leung K,Sheffer D,Pinson D,Foresman L,Narayan O

更新日期：1998-02-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting the central nervous system as a result of reactivation of the John Cunningham (JC) polyomavirus and occurs almost exclusively in immunosuppressed individuals. The disease course of PML is variable but usually progressive and often fa...

journal_title：Journal of neurovirology

authors： Holmes A,Wellings T,Walsh O,Rowlings P

更新日期：2020-12-01 00:00:00

abstract：:Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...

journal_title：Journal of neurovirology

authors： Seider TR,Gongvatana A,Woods AJ,Chen H,Porges EC,Cummings T,Correia S,Tashima K,Cohen RA

更新日期：2016-04-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

journal_title：Journal of neurovirology

authors： Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

更新日期：2014-12-01 00:00:00

abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...

journal_title：Journal of neurovirology

authors： Oliver KR,Scallan MF,Dyson H,Fazakerley JK

更新日期：1997-02-01 00:00:00

abstract：:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of...

journal_title：Journal of neurovirology

authors： Hobbs JA

更新日期：2006-06-01 00:00:00

abstract：:When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3...

journal_title：Journal of neurovirology

authors： Henderson G,Perng GC,Nesburn AB,Wechsler SL,Jones C

更新日期：2004-02-01 00:00:00

abstract：:Over the last 10 - 15 years, magnetic resonance imaging techniques have had a major impact in understanding and managing multiple sclerosis. The present review briefly summarises the current usefulness of spinal cord MRI in MS disease, examining the frequency, distribution and main characteristics of spine MS plaques;...

journal_title：Journal of neurovirology

authors： Bastianello S,Paolillo A,Giugni E,Giuliani S,Evangelisti G,Luccichenti G,Angeloni U,Colonnese C,Salvetti M,Gasperini C,Pozzilli C,Fieschi C

更新日期：2000-05-01 00:00:00

abstract：:We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use o...

journal_title：Journal of neurovirology

authors： Budhram A,Liu Y,Krawczyk M,Chan TLH,Burneo JG,Hosseini-Moghaddam SM,Shoesmith C

更新日期：2019-06-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...

journal_title：Journal of neurovirology

authors： Carpenter D,Hsiang C,Jiang X,Osorio N,BenMohamed L,Jones C,Wechsler SL

更新日期：2015-10-01 00:00:00

abstract：:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...

journal_title：Journal of neurovirology

authors： Deb C,Howe CL

更新日期：2008-05-01 00:00:00

abstract：:Over 65% of individuals infected with human immunodeficiency virus type 1 (HIV-1) reside in sub-Saharan Africa, and thus efforts to change the course of the HIV-1 pandemic should focus on this geographic region. Here, we discuss factors, including sexually transmitted diseases and hormonal contraceptive use, that impa...

journal_title：Journal of neurovirology

authors： Benki S,McClelland RS,Overbaugh J

更新日期：2005-01-01 00:00:00

abstract：:Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...

journal_title：Journal of neurovirology

authors： Heaton RK,Franklin DR,Ellis RJ,McCutchan JA,Letendre SL,Leblanc S,Corkran SH,Duarte NA,Clifford DB,Woods SP,Collier AC,Marra CM,Morgello S,Mindt MR,Taylor MJ,Marcotte TD,Atkinson JH,Wolfson T,Gelman BB,McArthur JC,

更新日期：2011-02-01 00:00:00

abstract：:In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...

journal_title：Journal of neurovirology

authors： Nagai M,Usuku K,Matsumoto W,Kodama D,Takenouchi N,Moritoyo T,Hashiguchi S,Ichinose M,Bangham CR,Izumo S,Osame M

更新日期：1998-12-01 00:00:00

abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...

journal_title：Journal of neurovirology

authors： van Marle G,Power C

更新日期：2005-04-01 00:00:00

abstract：:Toscana virus (Bunyaviridae family, Phlebovirus genus) is a sandfly fever virus responsible for human neurological infections. Sandfly viruses are transmitted by insect vectors (Phlebotomus species) and the infection is present in climatic areas that allow the life cycle of the vector. The arthropode-borne Toscana vir...

journal_title：Journal of neurovirology

authors： Valassina M,Cusi MG,Valensin PE

更新日期：2003-12-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...

journal_title：Journal of neurovirology

authors： Nguyen TB,Lucero GR,Chana G,Hult BJ,Tatro ET,Masliah E,Grant I,Achim CL,Everall IP,HIV Neurobehavioral Research Group.

更新日期：2009-09-01 00:00:00

abstract：:There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first d...

journal_title：Journal of neurovirology

authors： Mubanga E,Patel A,Siddiqi OK,Hanson BA,Dang X,Lakhi S,Mulundu G,Bender N,Koralnik IJ

更新日期：2019-08-01 00:00:00

abstract：:The last 3 years have seen a dramatic fall in mortality and morbidity from HIV infection. Four factors have contributed to this: an improved understanding of the pathogenesis of HIV infection; the availability of tests that could measure plasma viral burden; the development of new and more powerful drugs such as the p...

journal_title：Journal of neurovirology

authors： Powderly WG

更新日期：2000-05-01 00:00:00

abstract：:This single-center study attempts to quantify the incidence of symptomatic CSF viral escape (CSFVE) in patients receiving atazanavir/r (ATV/r)-containing regimen. We performed a retrospective analysis of patients receiving ATV/r-containing ART who were diagnosed with symptomatic CSFVE from August 2012 to January 2017....

journal_title：Journal of neurovirology

authors： Patel AK,Patel KK,Gohel S,Kumar A,Letendre S

更新日期：2018-08-01 00:00:00

abstract：:HIV-1 viral proteins have been implicated in endothelial dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on viral replication, reactivation o...

journal_title：Journal of neurovirology

authors： McMullen K,Bateman K,Stanley A,Combrinck M,Engelbrecht S,Bryer A

更新日期：2021-01-18 00:00:00

abstract：:Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

journal_title：Journal of neurovirology

authors： Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

更新日期：1999-04-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in regulating eukaryotic genome replication and gene expression in diverse biological systems. Here, we identified lncRNAs transcribed from pseudorabies virus (PRV)-infected PK-15 cells. Based on high-throughput sequencing data, we obtained 87,263,926 and 93,947,628 c...

journal_title：Journal of neurovirology

authors： Guan X,Liu J,Jiang H,Wu CX,Chen HC,Liu ZF

更新日期：2018-10-01 00:00:00

abstract：:A pandemic due to novel coronavirus arose in mid-December 2019 in Wuhan, China, and in 3 months' time swept the world. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic similarities to the virus (SARS-CoV-1) responsible for the severe acute respirator...

journal_title：Journal of neurovirology

authors： Berger JR

更新日期：2020-04-01 00:00:00

abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

journal_title：Journal of neurovirology

authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

更新日期：2016-04-01 00:00:00

abstract：:We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...

journal_title：Journal of neurovirology

authors： Sutherland RM,Chua MM,Lavi E,Weiss SR,Paterson Y

更新日期：1997-06-01 00:00:00