Abstract:
:Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections. The recent outbreak has resulted in an astonishing number of microcephaly cases in fetus and infants. Consequently, numerous studies were conducted using in vitro cell and in vivo animal models. These studies showed clear links between ZIKV infections and neurological abnormalities. Diagnosis methods based on nucleic acid and serological detection facilitated rapid and accurate identification of ZIKV infections. New transmission modalities such as sexual and transplacental transmission were uncovered. Given the seriousness of ZIKV infections, WHO declared the development of safe and effective vaccines and new antiviral drugs as an urgent global health priority. Rapid work in this direction has led to the identification of several vaccine and antiviral drug candidates. Here, we review the remarkable progress made in understanding the molecular links between ZIKV infections and neurological irregularities, new diagnosis methods, potential targets for antiviral drugs, and the current state of vaccine development.
journal_name
J Neuroviroljournal_title
Journal of neurovirologyauthors
Koppolu V,Shantha Raju Tdoi
10.1007/s13365-018-0614-8subject
Has Abstractpub_date
2018-06-01 00:00:00pages
255-272issue
3eissn
1355-0284issn
1538-2443pii
10.1007/s13365-018-0614-8journal_volume
24pub_type
杂志文章,评审abstract::In HIV patients, HCV co-infection has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Furthermore, PML has also been described in patients with cirrhosis, whether related to HCV infection or not. We describe here the case of a HIV/HCV co-infected patient with cirrhosis who d...
journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
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更新日期:2002-04-01 00:00:00
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journal_title:Journal of neurovirology
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1080/13550280802345715
更新日期:2008-11-01 00:00:00
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journal_title:Journal of neurovirology
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更新日期:2006-12-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...
journal_title:Journal of neurovirology
pub_type: 杂志文章,评审
doi:10.1007/s13365-014-0271-5
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Journal of neurovirology
pub_type: 杂志文章
doi:10.1007/s13365-012-0135-9
更新日期:2013-02-01 00:00:00
abstract::We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...
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pub_type: 杂志文章
doi:10.3109/13550289609146898
更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s13365-019-00791-6
更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neurovirology
pub_type: 杂志文章
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pub_type: 杂志文章
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