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Murine hepatitis virus--a model for virus-induced CNS demyelination.

Abstract：

:Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases such as multiple sclerosis (MS). These viruses are, therefore, used to study the role of the immune system in viral clearance from the CNS, in CNS demyelination, and in remyelination. Nevertheless, it is still unclear exactly how MHV induces demyelination and to what extent the immune system plays a role in this pathology. Here we review this field in the context of the immune response to MHV in the liver and the CNS focusing on studies that have been published in the past 5 years.

journal_name

J Neurovirol

journal_title

Journal of neurovirology

authors

Matthews AE,Weiss SR,Paterson Y

doi

10.1080/13550280290049534

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

76-85

issue

2

eissn

1355-0284

issn

1538-2443

journal_volume

8

pub_type

杂志文章,评审

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